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Protective Effect of Taurine on Apoptosis of Spinal Cord Cells in Diabetic Neuropathy Rats

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Taurine 11

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1155))

Abstract

Diabetes mellitus (DM) is a condition characterized by chronic hyperglycemia, which leads to diabetic neuropathy and apoptosis in the spinal cord. Taurine has been found to ameliorate the diabetic neuropathy and control apoptosis in various tissues. However, there are few reports that discuss the direct relationship between spinal cord and anti-apoptotic effect of taurine. In this study, DM was induced in male SD rats with STZ @ 25 mg/Kg of body weight in combination with high fat diet. After 2 weeks, they were divided into four groups as DM: diabetic rats, T1 (0.5%), T2 (1%) and T3 (2%) taurine solution, while control group was non-diabetic rats (no treatment). The results showed that DM increased apoptosis, decreased phosphorylated Akt and Bad. DM decreased expression of Bcl-2 and increased the Bax. Moreover, the release of cytochrome c into cytosol was increased in DM and activation of caspase-3 was also increased. However, taurine reversed all these abnormal changes in a dose dependent manner. Our results suggested the involvement of Akt/Bad signaling pathway and mitochondrial apoptosis pathway in protective effect of taurine against apoptosis in the spinal cord of diabetic rats. Therefore, taurine may be a potential medicine against diabetic neuropathy by controlling apoptosis.

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Conflict of Interest

It is declared that there is no conflict of interest among the authors.

Research Subjects

It is declared that no animal was harmed or hurt except according to ethics.

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It is declared that this manuscript is submitted after consent from all authors and all authors are aware of this submission.

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Author notes

  1. Inam-u-llah and Xiaoxia Shi have contributed as first authors equally to this work.

Authors and Affiliations

  1. Department of Occupational and Environmental Health, Dalian Medical University, Dalian, China

    Inam-u-llah, Xiaoxia Shi, Mengren Zhang, Kaixin Li, Pingan Wu & Fengyuan Piao

  2. Institute of Food Science and Technology, Chinese Academy of Agricultural Science, Beijing, China

    Raheel Suleman

  3. Department of Food Science and Technology, Muhammad Nawaz Sharif University of Agriculture, Multan, Pakistan

    Muhammad Shahbaz

  4. Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, China

    Ayaz Taj

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  1. Inam-u-llah
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  2. Xiaoxia Shi
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  3. Mengren Zhang
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  4. Kaixin Li
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Editor information

Editors and Affiliations

  1. College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, Liaoning, China

    Jianmin Hu

  2. Department of Occupational and Environmental Health, Dalian Medicine University, Dalian, Liaoning, China

    Fengyuan Piao

  3. Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, USA

    Stephen W. Schaffer

  4. Department of Biology, Center for Developmental Neuroscience, College of Staten Island, Staten Island, NY, USA

    Abdeslem El Idrissi

  5. Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA

    Jang-Yen Wu

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Inam-u-llah et al. (2019). Protective Effect of Taurine on Apoptosis of Spinal Cord Cells in Diabetic Neuropathy Rats. In: Hu, J., Piao, F., Schaffer, S., El Idrissi, A., Wu, JY. (eds) Taurine 11. Advances in Experimental Medicine and Biology, vol 1155. Springer, Singapore. https://doi.org/10.1007/978-981-13-8023-5_74

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