Abstract
Gamma ray irradiation causes immune suppression, in which oxidative stress reduces cell viability and damages immune cells. In the present study, we investigated whether Loliolus beka gray meat (LBM), which contains large amounts of taurine, protects against damage of murine splenocytes by oxidative stress. An aqueous extract of LBM (LBMW) was prepared, which contained plentiful levels of taurine. LBMW improved cell viability of gamma ray-irradiated murine splenocytes, an effect that was associated with significant reduction in the production of reactive oxygen species (ROS). We also showed that the production of nitric oxide (NO) and ROS in gamma ray-irradiated zebrafish embryos, as well as the death of the embryos, were diminished by LBMW. These data suggest that the consumption of taurine-rich foods, such as LBM, may be used in the protection of cells against oxidative stress.
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Bing SJ, Kim MJ, Ahn G, Im JH, Kim DS, Ha DH, Cho JH, Kim A, Jee Y (2014) Acidic polysaccharide of Panax ginseng regulates the mitochondria/caspase-dependent apoptotic pathway in radiation-induced damage to the jejunum in mice. Acta Histochem 116:514–521
Caldefie-Chézet F, Walrand S, Moinard C, Tridon A, Chassagne J, Vasson M (2002) Is the neutrophil reactive oxygen species production measured by luminol and lucigenin chemiluminescence intra or extracellular? Comparison with DCFH-DA flow cytometry and cytochrome c reduction. Clin Chim Acta 319:9–17
Chai TT, Law YC, Wong FC, Kim SK (2017) Enzyme-assisted discovery of antioxidant peptides from edible marine invertebrates: a review. Mar Drugs 15:42
Daniel J (1896) The x-rays [1] [letter]. Science 3:562–563
Fernando IPS, Kim M, Son KT, Jeong Y, Jeon YJ (2016) Antioxidant activity of marine algal polyphenolic compounds: a mechanistic approach [review]. J Med Food 19:1–14
Gligorovski S, Strekowski R, Barbati S, Vione D (2015) Environmental implications of hydroxyl radicals (•OH). Chem Rev 115:13051–13092
Han EJ, Um JH, Kim EA, Lee W, Kang N, Oh JY, Park SY, Jeon YJ (2017) Protective effects of an water extracts prepared from Loliolus beka gray meat against H2O2-induced oxidative stress in Chang liver cells and zebrafish embryo model. Adv Exp Med Biol:585–601
Imen H, Fatih Ö, Yesim Ö, Regenstein J (2015) Marine bioactive compounds and their health benefits: a review. CRFSFS 14:446–465
Itoh Y, Ma FH, Hoshi H, Oka M, Noda K, Ukai Y, Kojima H, Nagano T, Toda N (2000) Determination and bioimaging method for nitric oxide in biological specimens by diaminofluorescein fluorometry. Anal Biochem 287:203–209
Johnke RM, Sattler JA, Allison RR (2014) Radioprotective agents for radiation therapy: future trends. Future Oncol 10:2345–2357
Jong CJ, Azuma J, Schaffer S (2012) Mechanism underlying the antioxidant activity of taurine: prevention of mitochondrial oxidant production. Amino Acids 42:2223–2232
Kamiya K, Ozasa K, Akiba S, Niwa O, Kodama K, Takamura N, Zaharieva E, Kimura Y, Wakeford R (2015) Long-term effects of radiation exposure on health. Lancet 386:469–478
Kim EA, Lee SH, Ko C, Cha SH, Kang MC, Kang SM, Ko SC, Lee W, Ko JY, Lee JH, Kang N, Oh JY, Ahn G, Jee Y, Jeon YJ (2014) Protective effect of fucoidan against AAPH-induced oxidative stress in zebrafish model. Carbohydr Polym 102:185–191
Lee W, Kang N, Kim EA, Yang HW, Oh JY, Fernando IPS, Kim KN, Ahn G, Jeon YJ (2017) Radioprotective effects of a polysaccharide purified from Lactobacillus plantarum-fermented Ishige okamurae against oxidative stress caused by gamma ray-irradiation in zebrafish in vivo model. J Funct Foods 28:83–89
McGrath P, Li CQ (2008) Zebrafish: a predictive model for assessing drug-induced toxicity. Drug Discov Today 13:394–401
Moncada S, Palmer RMJ, Higgs EA (1989) Biosynthesis of nitric oxide from l-arginine: A pathway for the regulation of cell function and communication. Biochem Pharmacol 38:1709–1715
Norman M, Finn J, Hochberg F (2014) Cephalopods of the world. An annotated and illustrated catalogue of cephalopod species known to date. Volume 3. Octopods and vampire squids. FAO Species Cat Fish Purp 4:36–215
Oh JY, Fernando IS, Jeon YJ (2016) Potential applications of radioprotective phytochemicals from marine algae. Algae 31:403–414
Ray K, Stick M (2015) Radiation and health effects. Handbook of toxicology of chemical warfare agents, 2nd edn. Elsevier, Amsterdam, pp 431–446
Shimada K, Jong CJ, Takahashi K (2015) Role of ROS production and turnover in the antioxidant activity of taurine. Adv Exp Med Biol:581–596
Tucker B, Lardelli M (2007) A rapid apoptosis assay measuring relative acridine orange fluorescence in zebrafish embryos. Zebrafish 4:113–116
Um JH, Kim EA, Lee W, Kang N, Han EJ, Oh JY, Ahn G (2017) Protective effects of an enzymatic hydrolysate from Octopus ocellatus meat against hydrogen peroxide-induced oxidative stress in Chang liver cells and zebrafish embryo. Adv Exp Med Biol:603–620
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This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2018016523).
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Lee, W. et al. (2019). Radio-Protective Effects of Loliolus beka Gray Meat Consisted of a Plentiful Taurine Against Damages Caused by Gamma Ray Irradiation. In: Hu, J., Piao, F., Schaffer, S., El Idrissi, A., Wu, JY. (eds) Taurine 11. Advances in Experimental Medicine and Biology, vol 1155. Springer, Singapore. https://doi.org/10.1007/978-981-13-8023-5_63
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DOI: https://doi.org/10.1007/978-981-13-8023-5_63
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