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An Aqueous Extract of Octopus ocellatus Meat Protects Hepatocytes Against H2O2-Induced Oxidative Stress via the Regulation of Bcl-2/Bax Signaling

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Taurine 11

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1155))

Abstract

Octopus ocellatus meat (OM) is well known as a plentiful protein source. In this study, we evaluated the hepatoprotective effect of an aqueous extract of OM (OMA) against H2O2-triggered oxidative stress in human hepatocytes. First of all, taurine rich OMA showed a good ORAC value and reducing power and it was similar with that of ascorbic acid, which is known as a strong antioxidant. Also, OMA significantly improved H2O2-decreased cell viability by reducing the generation of intracellular reactive oxygen species (ROS) in hepatocytes. Interestingly, the stimulation of H2O2-induced the formations of apoptotic bodies and sub-G1 DNA content, whereas they were inhibited by the treatment with OMA. Furthermore, OMA regulated the protein expression levels of apoptotic molecules, such as Bax and Bcl-2. Taken together, this study suggests that OMA, which contains an abundant amount of taurine, protects hepatocytes from H2O2-triggered oxidative stress and might be a functional food material with hepatoprotective effects.

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Acknowledgements

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2018R1A6A1A03024314).

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Authors and Affiliations

  1. Freshwater Biosources Utilization Bureau, Bioresources Industrialization Support Division, Nakdonggang National Institute of Biological Resources (NNIBR), Sangju, Republic of Korea

    WonWoo Lee

  2. Department of Food Technology and Nutrition, Chonnam National University, Yeosu, Republic of Korea

    Eui Jeong Han, Eun-Ji Shin, Hee-Jin Han, Min Ju Kim & Ginnae Ahn

  3. Department of Marine Bio-Food Sciences, Chonnam National University, Yeosu, Republic of Korea

    Su-Jin Oh & Ginnae Ahn

  4. Natural Product Material Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup-si, Republic of Korea

    Kyungsook Jung

  5. Jeju International Marine Science Center for Research & Education, Korea Institute of Ocean Science & Technology (KIOST), Jeju, Republic of Korea

    Soo-Jin Heo & Eun-A Kim

  6. Chuncheon Center, Korea Basic Science Institute (KBSI), Chuncheon, Republic of Korea

    Kil-Nam Kim

  7. Faculty of Marine Technology, Chonnam National University, Yeosu, Republic of Korea

    Ihn-Sil Kwak

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  1. WonWoo Lee
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  11. Min Ju Kim
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  12. Ginnae Ahn
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Corresponding author

Correspondence to Ginnae Ahn .

Editor information

Editors and Affiliations

  1. College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, Liaoning, China

    Jianmin Hu

  2. Department of Occupational and Environmental Health, Dalian Medicine University, Dalian, Liaoning, China

    Fengyuan Piao

  3. Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, USA

    Stephen W. Schaffer

  4. Department of Biology, Center for Developmental Neuroscience, College of Staten Island, Staten Island, NY, USA

    Abdeslem El Idrissi

  5. Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA

    Jang-Yen Wu

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Lee, W. et al. (2019). An Aqueous Extract of Octopus ocellatus Meat Protects Hepatocytes Against H2O2-Induced Oxidative Stress via the Regulation of Bcl-2/Bax Signaling. In: Hu, J., Piao, F., Schaffer, S., El Idrissi, A., Wu, JY. (eds) Taurine 11. Advances in Experimental Medicine and Biology, vol 1155. Springer, Singapore. https://doi.org/10.1007/978-981-13-8023-5_54

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