Abstract
The loss of pancreatic β-cells plays a central role in the pathogenesis of both type 1 and type 2 diabetes, and many studies have been focused on ways to improve glucose homeostasis by preserving, expanding and improving the function of β-cell. Elevated levels of free fatty acids such as palmitate might contribute to the loss of β-cells. A marine squid, Loliolus beka has long been used as a food in Korea, China, Japan and Europe due to its tender meat and high taurine content. Here, we investigated the protective effects of a hot water extract of Loliolus beka meat (LBM) against palmitate toxicity in Ins-1 cells, a rat β-cell line. Treatment with LBM extract protected against palmitate-induced cytotoxicity and scavenged overproduction of nitric oxide, alkyl, and hydroxyl radicals. In addition, LBM extract protected against palmitate-induced DNA damage and β-cell dysfunction. These findings suggest that LBM protects pancreatic β-cells from palmitate-induced damage. LBM could be a potential therapeutic functional food for diabetes.
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Abbreviations
- DM:
-
diabetes mellitus
- ROSs:
-
Reactive oxygen species
References
Amaeze O, Ayoola G, Sofidiya M, Adepoju-Bello A, Adegoke A, Coker H (2011) Evaluation of antioxidant activity of Tetracarpidium conophorum (Müll. Arg) Hutch & Dalziel leaves. Oxidative medicine and cellular longevity 2011
Asmat U, Abad K, Ismail K (2016) Diabetes mellitus and oxidative stress—a concise review. Saudi Pharm J 24:547–553
Clark GJ, Pandya K, Lau-Cam CA (2017) The effect of metformin and taurine, alone and in combination, on the oxidative stress caused by diabetes in the rat brain. Adv Exp Med Biol 975:353–369
Creager MA, Luscher TF, Cosentino F, Beckman JA (2003) Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I. Circulation 108:1527–1532
El-Sayed WM, Al-Kahtani MA, Abdel-Moneim AM (2011) Prophylactic and therapeutic effects of taurine against aluminum-induced acute hepatotoxicity in mice. J Hazard Mater 192:880–886
Giacca A, Xiao C, Oprescu AI, Carpentier AC, Lewis GF (2011) Lipid-induced pancreatic beta-cell dysfunction: focus on in vivo studies. Am J Phys Endocrinol Metab 300:E255–E262
Giacco F, Brownlee M (2010) Oxidative stress and diabetic complications. Circ Res 107:1058–1070
Giroud S, Perret M, Gilbert C, Zahariev A, Goudable J, Le Maho Y, Oudart H, Momken I, Aujard F, Blanc S (2009) Dietary palmitate and linoleate oxidations, oxidative stress, and DNA damage differ according to season in mouse lemurs exposed to a chronic food deprivation. Am J Physiol Regul Integr Comp Physiol 297:R950–R959
Han EJ, Um JH, Kim EA, Lee W, Kang N, Oh JY, Park SY, Jeon YJ, Ahn CB, Lee SH, Ahn G (2017) Protective effects of an water extracts prepared from Loliolus beka Gray meat against H2O2-induced oxidative stress in Chang liver cells and Zebrafish embryo model. Adv Exp Med Biol 975:585–601
Hu M, Lin H, Yang L, Cheng Y, Zhang H (2017) Interleukin-22 restored mitochondrial damage and impaired glucose-stimulated insulin secretion through down-regulation of uncoupling protein-2 in INS-1 cells. J Biochem 161:433–439
Ito T, Schaffer SW, Azuma J (2012) The potential usefulness of taurine on diabetes mellitus and its complications. Amino Acids 42:1529–1539
Leonardi O, Mints G, Hussain MA (2003) Beta-cell apoptosis in the pathogenesis of human type 2 diabetes mellitus. Eur J Endocrinol 149:99–102
Liu H, Lin S, Lv Q, Yang Q, Wu G, Hu J, Yang J (2017) Taurine recovers testicular Steroidogenesis and spermatogenesis in Streptozotocin-induced diabetic rats. Adv Exp Med Biol 975:801–811
Luo F, Feng Y, Ma H, Liu C, Chen G, Wei X, Mao X, Li X, Xu Y, Tang S, Wen H, Jin J, Zhu Q (2017) Neutral ceramidase activity inhibition is involved in palmitate-induced apoptosis in INS-1 cells. Endocr J 64:767–776
Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santangelo C, Patane G, Boggi U, Piro S, Anello M, Bergamini E, Mosca F, Di Mario U, Del Prato S, Marchetti P (2002) Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 51:1437–1442
Maedler K, Spinas GA, Dyntar D, Moritz W, Kaiser N, Donath MY (2001) Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function. Diabetes 50:69–76
Messina SA, Dawson R Jr (2000) Attenuation of oxidative damage to DNA by taurine and taurine analogs. Adv Exp Med Biol 483:355–367
Oh YS, Lee YJ, Park EY, Jun HS (2011) Interleukin-6 treatment induces beta-cell apoptosis via STAT-3-mediated nitric oxide production. Diabetes Metab Res Rev 27:813–819
Oprescu AI, Bikopoulos G, Naassan A, Allister EM, Tang C, Park E, Uchino H, Lewis GF, Fantus IG, Rozakis-Adcock M, Wheeler MB, Giacca A (2007) Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo. Diabetes 56:2927–2937
Sato Y, Fujimoto S, Mukai E, Sato H, Tahara Y, Ogura K, Yamano G, Ogura M, Nagashima K, Inagaki N (2014) Palmitate induces reactive oxygen species production and β-cell dysfunction by activating nicotinamide adenine dinucleotide phosphate oxidase through Src signaling. J Diabetes Invest 5:19–26
Shi G, Sun C, Gu W, Yang M, Zhang X, Zhai N, Lu Y, Zhang Z, Shou P, Zhang Z, Ning G (2014) Free fatty acid receptor 2, a candidate target for type 1 diabetes, induces cell apoptosis through ERK signaling. J Mol Endocrinol 53:367–380
Sree SL, Sethupathy S (2014) Evaluation of the efficacy of taurine as an antioxidant in the management of patients with chronic periodontitis. Dent Res J 11:228–233
Weir GC, Bonner-Weir S (2013) Islet beta cell mass in diabetes and how it relates to function, birth, and death. Ann N Y Acad Sci 1281:92–105
Xu YJ, Arneja AS, Tappia PS, Dhalla NS (2008) The potential health benefits of taurine in cardiovascular disease. Exp Clin Cardiol 13:57–65
Acknowledgements
This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, & Future Planning (2014R1A1A3050501, 2017R1D1A1B03033794).
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Cha, SH., Han, E.J., Ahn, G., Jun, HS. (2019). Taurine-Rich-Containing Hot Water Extract of Loliolus Beka Gray Meat Scavenges Palmitate-Induced Free Radicals and Protects Against DNA Damage in Insulin Secreting β-Cells. In: Hu, J., Piao, F., Schaffer, S., El Idrissi, A., Wu, JY. (eds) Taurine 11. Advances in Experimental Medicine and Biology, vol 1155. Springer, Singapore. https://doi.org/10.1007/978-981-13-8023-5_45
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DOI: https://doi.org/10.1007/978-981-13-8023-5_45
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