Skip to main content
SpringerLink
Log in

Taurine Regulation of Peripheral Hemodynamics

  • Conference paper
  • First Online:
Taurine 11

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1155))

  • 2329 Accesses

Abstract

Taurine plays an important role in the modulation of cardiovascular function by acting not only within the brain but also within peripheral tissues. We found that IV injection of taurine to male rats caused hypotension and tachycardia. A single injection of taurine significantly lowered the systolic, diastolic and mean arterial pressure blood pressure in freely moving long Evans control rats. Previousely, we found that the endothelial cells express high levels of taurine transporters and GABAA receptors and showed that taurine activates GABAA receptors. Thus we suggest that the functional implication of GABAA receptors activation is the relaxation of the arterial muscularis, vasodilation and a decrease in blood pressure. Interestingly however, the effects of acute taurine injection were very different that chronic supplementation of taurine. When rats were supplemented taurine (0.05%, 4 weeks) in their drinking water, taurine has significant hypertensive properties. The increase in blood pressure was observed however only in females, males supplemented with taurine did not show an increase in systolic, diastolic or mean arterial pressure. In both genders however, taurine supplementation caused a significant tachycardia. Thus, we suggest that acute administration of taurine may be beneficial to lowering blood pressure. However, our data indicate that supplementation of taurine to females caused a significant increase in blood pressure. It remains to be seen the effect of taurine supplementation on hypertensive rats.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 329.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 419.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 449.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

TAU:

taurine

GABA:

γ-Aminobutyric acid

References

  • Abebe W, Mozaffari MS (2000) Effects of chronic taurine treatment on reactivity of the rat aorta. Aminosan 19:615–623

    CAS  Google Scholar 

  • Abebe W, Mozaffari MS (2003) Effect of taurine deficiency on adenosine receptor-mediated relaxation of the rat aorta. Vasc Pharmacol 40(4):219–228

    Article  CAS  Google Scholar 

  • Boujendar S, Reusens B, Merezak S et al (2002) Taurine supplementation to a low protein diet during foetal and early postnatal life restores a normal proliferation and apoptosis of rat pancreatic islets. Diabetologia 45:856–866

    Article  CAS  Google Scholar 

  • Bowery GN (1993) GABAB receptor pharmacology. Annu Rev Pharmacol 33:109–147

    Article  CAS  Google Scholar 

  • Cherif H, Reusens B, Dahri S et al (1996) Stimulatory effects of taurine on insulin secretion by fetal rat islets cultured in vitro. J Endocrinol 151:501–506

    Article  CAS  Google Scholar 

  • Curtis DR (1973) Bicuculline, GABA and central inhibition. Proc Aust Assoc Neurol 9:145–153

    CAS  PubMed  Google Scholar 

  • Dahri S, Snoeck A, Reusens-Billen B et al (1991) Islet function in offspring of mothers on low-protein diet during gestation. Diabetes 40(Suppl 2):115–120

    Article  CAS  Google Scholar 

  • del Olmo N, Bustamante J, del Rio RM, Soli J (2000) Taurine activates GABA(A) but not GABA(B) receptors in rat hippocampal CA1 area. Brain Res 864:298–307

    Article  Google Scholar 

  • El Idrissi A, Trenkner E (1999) Growth factors and taurine protect against excitotoxicity by stabilizing calcium homeostasis and energy metabolism. J Neurosci 19:9459–9468

    Article  Google Scholar 

  • El Idrissi A, Trenkner E (2003) Taurine regulates Mitochondrial calcium homeostasis. In: Lombardini JB, Schaffer SW, Azuma J (eds) Taurine 5 beginning the 21st century, Adv. Exp. med. Biol, vol 526. Kluwer Press, New York, pp 527–536

    Google Scholar 

  • El Idrissi A, Trenkner E (2004) Taurine as a modulator of excitatory and inhibitory neurotransmission. Neurochem Res 29:189–197

    Article  Google Scholar 

  • El Idrissi A, Messing J, Scalia J, Trenkner E (2003) Prevention of epileptic seizures through taurine. In: Lombardini JB, Schaffer SW, Azuma J (eds) Taurine 5 beginning the 21st century,. Adv Exp Med Biol, vol 526. Kluwer Press, NewYork, pp 515–525

    Google Scholar 

  • El Idrissi A, Okeke E, Yan X, Sidime F, Neuwirth LS (2013) Taurine regulation of blood pressure and vasoactivity. Adv Exp Med Biol 775:407–425

    Article  Google Scholar 

  • Elliott CAK, Hobbiger F (1959) Gamma aminobutyric acid: circulatory and respiratory effects in different species: re-investigation of the anti-strychine action in mice. J Physiol 146:70–84

    Article  CAS  Google Scholar 

  • Failli P, Fazzini A, Franconi F et al (1992) Taurine antagonizes the increases in intracellular calcium concentration induced by o~-adrenergic stimulation in freshly isolated guinea-pig cardiomyocytes. J Mol Cell Cardiol 24:1253–1265

    Article  CAS  Google Scholar 

  • Félétou M, Vanhoutte PM (2006) Endothelium-derived hyperpolarizing factor where are we now? Arterioscler Thromb Vasc Biol 26:1215–1225

    Article  Google Scholar 

  • Foos TM, Wu JY (2002) The role of taurine in the central nervous system and the modulation of intracellular calcium homeostasis. Neurochem Res 27:21–26

    Article  CAS  Google Scholar 

  • Franconi F, Giotti A, Manzini S, Martini F, Stendardi I, Zilletti L (1982) The effect of taurine on high potassium- and noradrenaline-induced contraction in rabbit ear artery. Br J Pharmacol 75:605–612

    Article  CAS  Google Scholar 

  • Fujita T, Sato Y (1984) The antihypertensive effect of taurine in DOCA-salt rats. J Hypertens 2(Suppl 2):S563–S565

    CAS  Google Scholar 

  • Harada H, Kitazaki K, Tsujino T, Watari Y, Iwata S, Nonaka H, Hayashi (2000) Oral taurine supplementation prevents the development of ethanol-induced hypertension in rats. Hypertens Res 23:277–284

    Article  CAS  Google Scholar 

  • Huxtable RJ (1989) Taurine in the central nervous system and the mammalian action actions of taurine. Prog Neurobiol 32:471–533

    Article  CAS  Google Scholar 

  • Huxtable RJ (1992) The physiological actions of taurine. Physiol Rev 72:101–163

    Article  CAS  Google Scholar 

  • Li N, Sawamura M, Nara Y, Ikeda K, Yamori Y (1996) Direct inhibitory effects of taurine on norepinephrine-induced contraction in mesenteric artery of stroke-prone spontaneously hypertensive rats. Adv Exp Med Biol 403:257–262

    Article  CAS  Google Scholar 

  • Lombardini JB (1985) Effects of taurine on calcium ion uptake and protein phosphorylation in rat retinal membrane preparations. J Neurochem 45:268–275

    Article  CAS  Google Scholar 

  • Lourenco R, Camilo ME (2002) Taurine: a conditionally essential amino acid in humans? An overview in health and disease. Nutr Hosp 17:262–270

    CAS  PubMed  Google Scholar 

  • Manzini S, Maggi CA, Meli A (1985) Inhibitory effect of GABA on sympathetic neurotransmission in rabbit ear artery. Arch Int Pharmacodyn 273:100–109

    CAS  PubMed  Google Scholar 

  • Meldrum MJ, Tu R, Patterson T et al (1994) The effect of taurine on blood pressure, and urinary sodium, potassium and calcium excretion. In: Huxtable R, Michalk DV (eds) Taurine in health and disease. Plenum Press, New York, pp 207–215

    Chapter  Google Scholar 

  • Mellor JR, Gunthorpe MJ, Randall AD (2000) The taurine uptake inhibitor guanidinoethyl sulphonate is an agonist at gamma-aminobutyric acid (A) receptors in cultured murine cerebellar granule cells. Neurosci Lett 286:25–28

    Article  CAS  Google Scholar 

  • Merezak S, Hardikar AA, Yajnik CS et al (2001) Intrauterine low protein diet increases fetal beta-cell sensitivity to no and il-1 beta: the protective role of taurine. J Endocrinol 171:299–308

    Article  CAS  Google Scholar 

  • Militante JD, Lombardini JB (1998) Pharmacological characterization of the effects of taurine on calcium uptake in the rat retina. Amino Acids 15:99–108

    Article  CAS  Google Scholar 

  • Monasterolo AL, Trumper L, Elias MM (1996) Effects of γ-aminobutyric acid agonists on the isolated perfused rat kidney. J Pharmacol Exp Ther 279:602–607

    CAS  PubMed  Google Scholar 

  • Nakagawa M, Takeda K, Yoshitomi T et al (1994) Antihypertensive effect of taurine on salt-induced hypertension. In: Huxtable R, Michalk DV (eds) Taurine in health and disease. Plenum Press, New York, pp 197–206

    Chapter  Google Scholar 

  • Nara Y, Yamori Y, Lovenberg W (1978) Effect of dietary taurine on blood pressure in spontaneously hypertensive rats. Biochem Pharmacol 27:2689–2692

    Article  CAS  Google Scholar 

  • Persson B, Henning M (1980) Central cardiovascular and biochemical effects of baclofen in the conscious rat. J Pharm Pharmacol 32:417–422

    Article  CAS  Google Scholar 

  • Quinn MR, Harris CL (1995) Tautine allosterically inhibits binding of [35S]-tbutylbicyclophosphorothionate (TBPS) to rat brain synaptic membranes. Neuropharmacology 34:1607–1613

    Article  CAS  Google Scholar 

  • Ristori MT, Verdetti J (1991) Effects of taurine on rat aorta in vitro. Fundam Clin Pharmacol 5:245–258

    Article  CAS  Google Scholar 

  • Saransaari P, Oja SS (2000) Taurine and neural cell damage. Amino Acids 19:509–526

    Article  CAS  Google Scholar 

  • Schaffer S, Takahashi K, Azuma J (2000) Role of osmoregulation in the actions of taurine. Amino Acids 19:527–546

    Article  CAS  Google Scholar 

  • Solis JM, Herranz AS, Herreras O et al (1988) Does taurine act as an osmoregulatory substance in the rat brain? Neurosci Lett 91:53–58

    Article  CAS  Google Scholar 

  • Sturman JA (1993) Taurine in development. Physiol Rev 73:119–147

    Article  CAS  Google Scholar 

  • Takahashi H, Tiba M, Iino M, Takayasu T (1955) The effect of gamma-aminobutyric acid on blood pressure. Jpn J Physiol 5(4):334–341

    Article  CAS  Google Scholar 

  • Tsukada Y, Hirano S, Nagata Y, Mastutani T (1960) Metabolic studies of gamma-aminobutyric acid in mammalian tissues. In: Roberts E (ed) Inhibition in the nervous system and gamma-aminobutyric acid. Pergamon, New York, p 163

    Google Scholar 

  • Wang DS, Xu TL, Pang ZP, Li JS, Akaike N (1998) Taurine-activated chloride currents in the rat sacral dorsal commissural neurons. Brain Res 792:41–47

    Article  CAS  Google Scholar 

  • Wu JY, Tang XW, Schloss JV, Faiman MD (1998) Regulation of taurine biosynthesis and its physiological significance in the brain. Adv Exp Med Biol 442:339–345

    Article  CAS  Google Scholar 

Download references

Acknowledgement

This work was supported by CDN, PSC-CUNY and CSI. The authors declare that they have no conflict of interest.This chapter was modified from the paper published by our group in Adv Exp Med Biol. (El Idrissi et al. 2013; 775:407–425). The related contents are re-used with the permission.

Author information

Authors and Affiliations

  1. Department of Biology, Center for Developmental Neuroscience, College of Staten Island, Staten Island, NY, USA

    Francoise Sidime & Abdeslem El Idrissi

Authors
  1. Francoise Sidime
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Abdeslem El Idrissi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Abdeslem El Idrissi .

Editor information

Editors and Affiliations

  1. College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, Liaoning, China

    Jianmin Hu

  2. Department of Occupational and Environmental Health, Dalian Medicine University, Dalian, Liaoning, China

    Fengyuan Piao

  3. Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, USA

    Stephen W. Schaffer

  4. Department of Biology, Center for Developmental Neuroscience, College of Staten Island, Staten Island, NY, USA

    Abdeslem El Idrissi

  5. Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA

    Jang-Yen Wu

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Singapore Pte Ltd.

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Sidime, F., El Idrissi, A. (2019). Taurine Regulation of Peripheral Hemodynamics. In: Hu, J., Piao, F., Schaffer, S., El Idrissi, A., Wu, JY. (eds) Taurine 11. Advances in Experimental Medicine and Biology, vol 1155. Springer, Singapore. https://doi.org/10.1007/978-981-13-8023-5_16

Download citation

Publish with us

Policies and ethics

Search

Navigation