Abstract
Aberrant activity of all the 18 HDACs does not form the etiology of neuronal disorders. Certain HDACs have strong implications in these disorders, while others are not at all involved. Thus therapeutic intervention against neurological disorders demands selective rather than pan-targeting. In addition to selectivity, these inhibitors should have high brain penetrance to achieve the desired therapeutic effect. This chapter discusses the different computational and medicinal chemistry approaches for designing selective HDAC inhibitors. Further, the chapter also gives bird’s eye view on image-guided approach for identifying the brain-penetrant HDACi.
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Ganai, S.A. (2019). Designing of Selective and Brain-Penetrant HDAC Inhibitors for Effective Therapy Against Neurological Disorders. In: Histone Deacetylase Inhibitors — Epidrugs for Neurological Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-13-8019-8_8
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DOI: https://doi.org/10.1007/978-981-13-8019-8_8
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