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Epigenetics and its Implications in Neurological Disorders

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Histone Deacetylase Inhibitors — Epidrugs for Neurological Disorders

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Abstract

Epigenetic players perform a significant role in governing gene expression programs as they precisely regulate the various post-translational modifications of histone and non-histone substrates. Epigenetic dysregulation due to aberrant activity of these players alters homeostasis provoking neurological complications. Here I discuss the amendments of the definition of epigenetics over time and the various post-translational modifications that histone proteins undergo. Moreover, the altered activity and expression of various epigenetic enzymes in distinct neurological disorders including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis (ALS) will be thoroughly discussed.

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  1. Division of Basic Sciences and Humanities, Faculty of Agriculture, SKUAST-Kashmir, Wadura Sopore, Jammu and Kashmir, India

    Shabir Ahmad Ganai

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Ganai, S.A. (2019). Epigenetics and its Implications in Neurological Disorders. In: Histone Deacetylase Inhibitors — Epidrugs for Neurological Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-13-8019-8_1

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