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Minimal Residual Disease Assessment in Myeloma

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Hematopathology

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Abstract

Multiple myeloma is a plasma cell malignancy that manifests with bone lesions, anemia, hypercalcemia and renal dysfunction. With the advent of proteasome inhibitors and immunomodulatory agents, the response rates have significantly improved leading to a higher rates of complete response and stringent complete response. However, patients still relapse over a period of time even after consolidation of response by autologous stem cell trasplantation. There is therefore a need to assess the medullary and extramedullary compartments of residual plasma cell burden to identify patients who will require further therapy. Assessing minimal residual disease in the intramedullary compartment is best done by multiprameter flow cytometry. With standardised 8-10 colour flow cytometry, detection of upto 0.001% neoplastic plasma cells is now possible. This chapter will discuss the details of intramedullary minimal residual disease detection in multiple myeloma.

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Authors and Affiliations

  1. Department of Hematology, Sir Ganga Ram Hospital, New Delhi, India

    Jasmita Dass & Jyoti Kotwal

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  1. Jasmita Dass
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  1. Department of Hematology, All India Institute of Medical Sciences, New Delhi, India

    Renu Saxena

  2. Department of Hematology, All India Institute of Medical Sciences, New Delhi, India

    Hara Prasad Pati

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Dass, J., Kotwal, J. (2019). Minimal Residual Disease Assessment in Myeloma. In: Saxena, R., Pati, H. (eds) Hematopathology. Springer, Singapore. https://doi.org/10.1007/978-981-13-7713-6_14

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