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Radioimmunoimaging and Targeted Therapy

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Nuclear Medicine in Oncology

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Abstract

More than 20 years ago, Dr. Zhu from China said, “As the world-renowned achievements of radioimmunoassay for trace substance detection are attributed to the multidisciplinary effect of nuclear medicine and immunology, likewise, success of radioimmunoimaging (RII) and radioimmunotherapy (RIT) are dependent on the interaction of these two disciplines, which opens up a new way for the diagnosis and treatment of cancer.” RII and RIT, together termed radioimmunotheranostics, are characterized by radioisotope-labeled antibody or fragments which can recognize some specific antigen; the ultimate goal of which is to diagnose or treat cancer or other diseases. Radioimmunotheranostics has a 70-year history of development, and numerous scholars who came from diverse fields including medicine, immunology, bioengineering, etc. dedicated in this field made unremittent efforts for human health. With the rapid development of medical and bioengineering technology, novel theranostic probes, which can recognize a specific antigen on the cancer cell or are associated with the tumor microenvironment, are not limited to antibodies but include some small-molecule ligands. In this chapter, we would also give some introduction of radionuclide-labeled non-antibody imaging and therapy, while the major focus will be on traditional RII and RIT.

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Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China

    Yafu Yin

  2. The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Steven Rowe

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  1. Yafu Yin
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  2. Steven Rowe
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Editors and Affiliations

  1. Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China

    Gang Huang

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© 2019 Springer Nature Singapore Pte Ltd. and Shanghai Jiao Tong University Press

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Yin, Y., Rowe, S. (2019). Radioimmunoimaging and Targeted Therapy. In: Huang, G. (eds) Nuclear Medicine in Oncology. Springer, Singapore. https://doi.org/10.1007/978-981-13-7458-6_13

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  • DOI: https://doi.org/10.1007/978-981-13-7458-6_13

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-7457-9

  • Online ISBN: 978-981-13-7458-6

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