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Specifics 1: Head and Neck Cancer and Esophageal Cancer

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Biomarkers in Cancer Therapy

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Abstract

Head and neck cancer (HNC) and esophageal cancer (EC) are aggressive diseases associated with high morbidity and mortality. The poor prognosis is mainly attributed to the absence of specific symptoms during early-stage cancer and the lack of reliable biomarkers. The identification of biomarkers has the potential to aid early diagnosis and prediction of recurrence and therapeutic efficacy. Biomarkers can also enable the improvement of long-term prognosis through personalized treatment strategies. The discovery of noninvasive methods to detect and monitor tumors remains a major challenge in clinical oncology. In this chapter, we review the development and feasibility of biomarkers, especially via “liquid biopsy,” such as circulating tumor cells (CTCs), cell-free DNA (cfDNA), circulating tumor DNA (ctDNA), circulating microRNAs (miRNAs), and autoantibodies against tumor-associated antigens (TAAs). We highlight new insights into the biomarkers of HNC and EC in clinical application and identify promising avenues of research in this emerging field of study, ultimately leading to improved HNC and EC patient care.

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Author notes

  1. Shuhei Ito

    Present address: Department of Surgery, National Fukuoka-Higashi Medical Center, Chidori, Koga, Fukuoka, Japan

  2. Shuhei Ito and Kensuke Koike contributed equally to this work.

Authors and Affiliations

  1. Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan

    Shuhei Ito, Kensuke Koike & Koshi Mimori

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  1. Shuhei Ito
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  2. Kensuke Koike
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  3. Koshi Mimori
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Correspondence to Koshi Mimori .

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  1. Gastroenterology Center (Surgery), Toho University Omori Medical Center, Tokyo, Japan

    Hideaki Shimada

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Ito, S., Koike, K., Mimori, K. (2019). Specifics 1: Head and Neck Cancer and Esophageal Cancer. In: Shimada, H. (eds) Biomarkers in Cancer Therapy. Springer, Singapore. https://doi.org/10.1007/978-981-13-7295-7_6

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