Abstract
Metabolic cataract is loss of lens transparency caused by an insult to the nuclear or lenticular fibres due to an underlying metabolic disorder. They may present as an isolated condition or as a part of a particular syndrome. Most of the times being considered as a part of a congenital syndrome, the exact incidence of this cataract is unknown. Screening for underlying metabolic disorders in children with bilateral cataract can lead to their early detection and avoidance of consequences with timely initiation of treatment [1, 2]. The metabolic disorders have been divided according to the age of appearance of cataract (Table 3.1). This may be helpful in the differential diagnosis of inborn errors of metabolism presenting with cataracts. Also, specific lens changes seen in different disorders provides diagnostic clues [1–3]. Few of these disorders are described here in detail.
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References
Wijburg MT, Wenniger-Prick LJM, Bosch AM, Visser G, Bams-Mengerink A. Bilateral cataract in childhood years: always an indication for screening on a metabolic disorder. Ned Tijdschr Geneeskd. 2008;152(11):632–6.
Cavallini GM, Forlini M, Masini C, et al. Dismetabolic cataracts: clinicopathologic overview and surgical management with B-MICS technique. J Genet Syndr Gene Ther. 2013;4(7):165.
Endres W, Shin YS. Cataract and metabolic disease. J Inherit Metab Dis. 1990;13(4):509–16.
Bosch AM, Bakker HD, van Gennip AH, van Kempen JV, Wanders RJA, Wijburg FA. Clinical features of galactokinase deficiency: a review of the literature. J Inherit Metab Dis. 2002;25(8):629–34.
Stambolian D. Galactose and cataract. Surv Ophthalmol. 1988;32(5):333–49.
Yunis JJ, Lewandowski RC, Sanfilippo SJ, Tsai MY, Foni I, Bruhl HH. Clinical manifestations of mannosidosis—a longitudinal study. Am J Med. 1976;61(6):841–8.
Arbisser AI, Murphree AL, Garcia CA, Howell RR. Ocular findings in mannosidosis. Am J Ophthalmol. 1976;82(3):465–71.
Aguire G, Stamm L, Haskins M, Jezyk P. Animal models of metabolic eye diseases. Defects in glycoproteins degradation. Mannosidosis. In: Goldberg’s, editor. In genetic and metabolic eye diseases, vol. 2. Boston: Little Brown and co.; 1986. p. 152–7.
Merin S, Crawford JS. Hypoglycemia and infantile cataract. Arch Ophthalmol. 1971 Nov;86(5):495–8.
Vetter V, Shin YS. Lens sorbitol dehydrogenase deficiency in a patient with congenital cataract. Eur J Pediatr. 1995;154(5):389–91.
Goturu A, Jain N, Lewis I. Bilateral cataracts and insulin oedema in a child with type 1 diabetes mellitus. BMJ Case Rep. 2013;2013:bcr2012008235.
Uspal N, Schapiro E. Cataracts as the initial manifestation of type 1 diabetes mellitus. Pediatr Emerg Care. 2011;27(2):132–4.
Bilginturan AN, Jackson RL, Ide CH. Transitory cataracts in children with diabetes mellitus. Pediatrics. 1977;60:106–9.
Santiago AP, Rosenbaum AL, Masket S. Insulin-dependent diabetes mellitus appearing as bilateral mature diabetic cataracts in a child. Arch Ophthalmol. 1997;115:422–3.
Bron AJ, Sparrow J, Brown NA, Harding JJ, Blakytny R. The lens in diabetes. Eye (Lond). 1993;7:260–75.
Haviv YS, Safadi R, Zamir E. A rapidly progressive cataract in a patient with autoimmune hypoparathyroidism and acute liver and renal failure. Am J Nephrol. 1999;19(4):523–6.
Sodi A, Ioannidis A, Pitz S. Ophthalmological manifestations of Fabry disease. In: Mehta A, Beck M, Sunder-Plassmann G, editors. Fabry disease: perspectives from 5 years of FOS. Oxford: Oxford PharmaGenesis; 2006.
Savige J, Sheth S, Leys A, Nicholson A, Mack HG, Colville D. Ocular features in Alport syndrome: pathogenesis and clinical significance. Clin J Am Soc Nephrol. 2015;10(4):703–9.
Langwińska-Wośko E, Litwin T, Dzieżyc K, Członkowska A. The sunflower cataract in Wilson’s disease: pathognomonic sign or rare finding? Acta Neurol Belg. 2016;116:325–8.
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Surve, A., Dhull, C., Khokhar, S.K. (2019). Metabolic Cataract. In: Khokhar, S., Dhull, C. (eds) Atlas of Pediatric Cataract. Springer, Singapore. https://doi.org/10.1007/978-981-13-6939-1_3
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DOI: https://doi.org/10.1007/978-981-13-6939-1_3
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