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Food Allergy pp 13–39Cite as

Species and Structure of Food Allergens: Epitopes and Cross-Reactivity

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Abstract

In recent years, with the improvement of food production and industrialization as well as the development of transgenic technology and the popularization of genetically modified food, the incidence of food allergic diseases is on the rise and has become a common chronic disease that endangers people’s physical and mental health, especially those of children’s. The World Health Organization (WHO) has listed food allergy as the sixth problem affecting people’s health, and the research on food allergen has become one of the public issues of global concern. This chapter will discuss multiple allergens in the “big eight” categories of food allergens. Biochemical characteristics associated with food allergens like the presence of multiple, linear IgE-binding epitopes seem to predominate among food allergens, more so than common structural features. Here, the recent studies on the identification of structure and potential epitopes of food allergens are also presented. Due to the high sequence homology and structural similarity of food allergens in different species, especially the major allergens, cross-reactivity is common; therefore a comprehensive introduction to the cross-reactivity among different origins of allergens is also reviewed.

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References

  • Abdel Rahman AM, Kamath SD, Gagné S, Lopata AL, Helleur R (2013) Comprehensive proteomics approach in characterizing and quantifying allergenic proteins from northern shrimp: toward better occupational asthma prevention. J Proteome Res 12:647–656

    Article  CAS  PubMed  Google Scholar 

  • Aisen P, Leibman A, Reich H (1966) Studies on the binding of iron to transferrin and conalbumin. J Biol Chem 241:1666

    CAS  PubMed  Google Scholar 

  • Alenius H, Kalkkinen N, Reunala T, Turjanmaa K, Palosuo T (1996) The main IgE-binding epitope of a major latex allergen, prohevein, is present in its N-terminal 43-amino acid fragment, hevein. J Immunol 156:1618–1625

    CAS  PubMed  Google Scholar 

  • Amo A, Rodríguezpérez R, Blanco J, Villota J, Juste S, Moneo I, Caballero ML (2010) Gal d 6 is the second allergen characterized from egg yolk. J Agric Food Chem 58:7453–7457

    Article  CAS  PubMed  Google Scholar 

  • Arnon R, Maron E, Sela M, Anfinsen C (1971) Antibodies reactive with native lysozyme elicited by a completely synthetic antigen. Proc Natl Acad Sci U S A 68:1450–1455

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Asero R, Mistrello G, Amato S, Zanoni D, Barocci F, Caldironi G (2003) Detection of clinical markers of sensitization to profilin in patients allergic to plant-derived foods. J Allergy Clin Immunol 112:427–432

    Article  CAS  PubMed  Google Scholar 

  • Atassi M, Lee C (1978) The precise and entire antigenic structure of native lysozyme. Biochem J 171:429–434

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ayuso R, Grishina Gibanez MD (2009) Sarcoplasmic calcium-binding protein is an EF-hand-type protein identified as a new shrimp allergen. J Allergy Clin Immunol 124:114–120

    Article  CAS  PubMed  Google Scholar 

  • Ayuso R, Lehrer S, Reese G (2002a) Identification of continuous, allergenic regions of the major shrimp allergen Pen a 1 (tropomyosin). Int Arch Allergy Immunol 127:27–37

    Article  CAS  PubMed  Google Scholar 

  • Ayuso R, Reese G, Leong-Kee S, Plante M, Lehrer S (2002b) Molecular basis of arthropod cross-reactivity: IgE-binding cross-reactive epitopes of shrimp, house dust mite and cockroach tropomyosins. Int Arch Allergy Immunol 129:38–48

    Article  CAS  PubMed  Google Scholar 

  • Ayuso R et al (2008) Myosin light chain is a novel shrimp allergen, Lit v 3. J Allergy Clin Immunol 122:795–802

    Article  CAS  PubMed  Google Scholar 

  • Ayuso R et al (2010) Greater epitope recognition of shrimp allergens by children than by adults suggests that shrimp sensitization decreases with age. J Allergy Clin Immunol 125:1286–1293.e1283

    Article  CAS  PubMed  Google Scholar 

  • Ball G, Shelton M, Walsh B, Hill D, Hosking C, Howden M (2010) A major continuous allergenic epitope of bovine beta-lactoglobulin recognized by human IgE binding. Clin Exp Allergy 24:758–764

    Article  Google Scholar 

  • Barre A, Sordet C, Culerrier R, Rancé F, Didier A, Rougé P (2008) Vicilin allergens of peanut and tree nuts (walnut, hazelnut and cashew nut) share structurally related IgE-binding epitopes. Mol Immunol 45:1231–1240

    Article  CAS  PubMed  Google Scholar 

  • Battais F et al (2015) Identification of IgE-binding epitopes on gliadins for patients with food allergy to wheat. Allergy 60:815–821

    Article  CAS  Google Scholar 

  • Bauermeister K et al (2011) Generation of a comprehensive panel of crustacean allergens from the North Sea shrimp Crangon crangon. Mol Immunol 48:1983–1992

    Article  CAS  PubMed  Google Scholar 

  • Bernard H et al (2000) Molecular basis of IgE cross-reactivity between human beta-casein and bovine beta-casein, a major allergen of milk. Mol Immunol 37:161–167

    Article  CAS  PubMed  Google Scholar 

  • Bernhiselbroadbent J, Dintzis H, Dintzis R, Sampson H (1994) Allergenicity and antigenicity of chicken egg ovomucoid (gal d iii) compared with ovalbumin (gal d i) in children with egg allergy and in mice. J Allergy Clin Immunol 93:1047–1059

    Article  CAS  Google Scholar 

  • Blanco C, Carrillo T, Castillo R, Quiralte J, Cuevas M (1994) Avocado hypersensitivity. Allergy 49:454

    Article  CAS  PubMed  Google Scholar 

  • Bleumink E, Young E (1971) Studies on the atopic allergen in hen’s egg. II. Further characterization of the skin-reactive fraction in egg-white; immuno-electrophoretic studies. Int Arch Allergy Appl Immunol 40:72

    Article  CAS  PubMed  Google Scholar 

  • Breiteneder H (2004) Thaumatin-like proteins – a new family of pollen and fruit allergens. Allergy 59:479

    Article  PubMed  Google Scholar 

  • Brown JH, Cohen C (2005) Regulation of muscle contraction by tropomyosin and troponin: how structure illuminates function. Adv Protein Chem 71:121

    Article  CAS  PubMed  Google Scholar 

  • Cai QF, Liu GM, Li T, Hara K, Wang XC, Su WJ, Cao MJ (2010) Purification and characterization of parvalbumins, the major allergens in red stingray (Dasyatis akajei). J Agric Food Chem 58:12964

    Article  CAS  PubMed  Google Scholar 

  • Cantisani A et al (1997) Detection of specific IgE to human milk proteins in sera of atopic infants. FEBS Lett 412:515–517

    Article  CAS  PubMed  Google Scholar 

  • Caubet J, Wang J (2011) Current understanding of egg allergy. Pediatr Clin N Am 58:427–443

    Article  Google Scholar 

  • Chapman MD, Wood RA (2001) The role and remediation of animal allergens in allergic diseases. J Allergy Clin Immunol 107:S414–S421

    Article  CAS  PubMed  Google Scholar 

  • Chatchatee P, Järvinen K, Bardina L, Beyer K, Sampson H (2001) Identification of IgE- and IgG-binding epitopes on alpha(s1)-casein: differences in patients with persistent and transient cow’s milk allergy. J Allergy Clin Immunol 107:379–383

    Article  CAS  PubMed  Google Scholar 

  • Chen HL, Cao MJ, Cai QF, Su WJ, Mao HY, Liu GM (2013) Purification and characterisation of sarcoplasmic calcium-binding protein, a novel allergen of red swamp crayfish (Procambarus clarkii). Food Chem 139:213–223

    Article  CAS  PubMed  Google Scholar 

  • Curioni A, Santucci B, Cristaudo A, Canistraci C, Pietravalle M, Simonato B, Giannattasio M (2010) Urticaria from beer: an immediate hypersensitivity reaction due to a 10-kDa protein derived from barley. Clin Exp Allergy 29:407–413

    Article  Google Scholar 

  • Daul C, Slattery M, Reese G, Lehrer S (1994) Identification of the major brown shrimp (Penaeus aztecus) allergen as the muscle protein tropomyosin. Int Arch Allergy Immunol 105:49–55

    Article  CAS  PubMed  Google Scholar 

  • Dunwell J (1998) Cupins: a new superfamily of functionally diverse proteins that include germins and plant storage proteins. Biotechnol Genet Eng Rev 15:1–32. https://doi.org/10.1080/02648725.1998.10647950

    Article  CAS  PubMed  Google Scholar 

  • Dunwell J, Purvis A, Khuri S (2004) Cupins: the most functionally diverse protein superfamily? Phytochemistry 65:7–17. https://doi.org/10.1016/j.phytochem.2003.08.016

    Article  CAS  PubMed  Google Scholar 

  • Egger M, Hauser M, Mari A, Ferreira F, Gadermaier G (2010) The role of lipid transfer proteins in allergic diseases. Curr Allergy Asthma Rep 10:326–335

    Article  CAS  PubMed  Google Scholar 

  • Elsayed S, Apold J (2010) Immunochemical analysis of cod fish allergen M: locations of the immunoglobulin binding sites as demonstrated by the native and synthetic peptides. Allergy 38:449–459

    Article  Google Scholar 

  • Gammon G, Shastri N, Cogswell J, Wilbltr S, Sadegh-Nasseri S, Krzych U (2010) The choice of T-cell epitopes utilized on a protein antigen depends on multiple factors distant from, as well as at the determinant site. Immunol Rev 98:54–73

    Article  Google Scholar 

  • Geroldinger-Simic M et al (2011) Birch pollen-related food allergy: clinical aspects and the role of allergen-specific IgE and IgG 4 antibodies. J Allergy Clin Immunol 127:616–622.e611

    Article  CAS  PubMed  Google Scholar 

  • Hamada Y, Nagashima Y, Shiomi K (2001) Identification of collagen as a new fish allergen. J Agric Chem Soc Jpn 65:285–291

    CAS  Google Scholar 

  • Hoffman DR (1983) Immunochemical identification of the allergens in egg white. J Allergy Clin Immunol 71:481–486

    Article  CAS  PubMed  Google Scholar 

  • Hoffman D, Day JE, Miller J (1981) The major heat stable allergen of shrimp. Ann Allergy 47:17

    CAS  PubMed  Google Scholar 

  • Hoffmannsommergruber K (2000) Plant allergens and pathogenesis-related proteins. What do they have in common? Int Arch Allergy Immunol 122:155–166

    Article  CAS  Google Scholar 

  • Hopp T, Woods K (1981) Prediction of protein antigenic determinants from amino acid sequences. Proc Natl Acad Sci U S A 78:3824–3828

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hopp T, Woods K (1982) Immunochemical studies on alpha-lactalbumin. Mol Immunol 19:1453

    Article  CAS  PubMed  Google Scholar 

  • Huggett A, Hischenhuber C (1998) Food manufacturing initiatives to protect the allergic consumer. Allergy 53:89–92

    Article  CAS  PubMed  Google Scholar 

  • Ibrahimi I, Eder J, Prager E, Wilson A, Arnon R (1980) The effect of a single amino acid substitution on the antigenic specificity of the loop region of lysozyme. Mol Immunol 17:37–46

    Article  CAS  PubMed  Google Scholar 

  • Ishikawa M, Suzuki F, Ishida M, Nagashima Y, Shiomi K (2010) Identification of tropomyosin as a major allergen in the octopus Octopus vulgaris and elucidation of its IgE-binding epitopes. Fish Sci 67:934–942

    Article  Google Scholar 

  • Jacobsen B et al (2008) The panel of egg allergens, Gal d 1-Gal d 5: their improved purification and characterization. Mol Nutr Food Res 52:S176–S185

    PubMed  Google Scholar 

  • Jain S, Srivastava S, Sarin NB, Kav NN (2006) Proteomics reveals elevated levels of PR 10 proteins in saline-tolerant peanut (Arachis hypogaea) calli. Plant Physiol Biochem PPB 44:253–259. https://doi.org/10.1016/j.plaphy.2006.04.006

    Article  CAS  PubMed  Google Scholar 

  • Jang Y, Lim K, Kim B (2010) Analysis of T cell reactivities to phosphorylcholine-conjugated hen egg lysozyme in C57BL/6 mice: hapten-conjugate specificity reflects an altered expression of a major carrier epitope. Eur J Immunol 21:1303–1310

    Article  Google Scholar 

  • Jankovicova B et al (2008) Epitope mapping of allergen ovalbumin using biofunctionalized magnetic beads packed in microfluidic channels the first step towards epitope-based vaccines. J Chromatogr A 1206:64–71

    Article  CAS  PubMed  Google Scholar 

  • Jarolim E, Rumpold H, Endler A, Ebner H, Breitenbach M, Scheiner O, Kraft D (2010) IgE and IgG antibodies of patients with allergy to birch pollen as tools to define the allergen profile of Betula verrucosa *. Allergy 44:385–395

    Article  Google Scholar 

  • Javier MF, Alfonso C (2008) 2S albumin storage proteins: what makes them food allergens? Open Biochem J 2:16–28

    Article  Google Scholar 

  • Jenkins J, Breiteneder H, Mills E (2007) Evolutionary distance from human homologs reflects allergenicity of animal food proteins. J Allergy Clin Immunol 120:1399–1405

    Article  CAS  PubMed  Google Scholar 

  • Jeong K, Hong C, Yong T (2006) Allergenic tropomyosins and their cross-reactivities. Protein Pept Lett 13:835–845

    Article  CAS  PubMed  Google Scholar 

  • Jiingguang C, Su SN, Borluen C, Howjing L, Luping C (2011) Proteome mining for novel IgE-binding proteins from the German cockroach (Blattella germanica) and allergen profiling of patients. Proteomics 5:202–202

    Google Scholar 

  • Kahlert H, Petersen A, Becker W, Schlaak M (1992) Epitope analysis of the allergen ovalbumin (Gal d II) with monoclonal antibodies and patients’ IgE. Mol Immunol 29:1191–1201

    Article  CAS  PubMed  Google Scholar 

  • Kanduc D, Lucchese A, Mittelman A (2001) Individuation of monoclonal anti-HPV16 E7 antibody linear peptide epitope by computational biology. Peptides 22:1981–1985

    Article  CAS  PubMed  Google Scholar 

  • Kato I, Schrode J, Kohr W, Laskowski M Jr (1987) Chicken ovomucoid: determination of its amino acid sequence, determination of the trypsin reactive site, and preparation of all three of its domains. Biochemistry 26:193

    Article  CAS  PubMed  Google Scholar 

  • Knobeloch D et al (2010) A coleopteran triosephosphate isomerase: X-ray structure and phylogenetic impact of insect sequences. Insect Mol Biol 19:35–48

    Article  CAS  PubMed  Google Scholar 

  • Kreis M, Forde B, Rahman S, Miflin B, Shewry P (1985) Molecular evolution of the seed storage proteins of barley, rye and wheat. J Mol Biol 183:499–502

    Article  CAS  PubMed  Google Scholar 

  • Leone P et al (2006) Resolution of the structure of the allergenic and antifungal banana fruit thaumatin-like protein at 1.7-A. Biochimie 88:45–52

    Article  CAS  PubMed  Google Scholar 

  • Leung P et al (1994) Cloning, expression, and primary structure of Metapenaeus ensis tropomyosin, the major heat-stable shrimp allergen. J Allergy Clin Immunol 94:882

    Article  CAS  PubMed  Google Scholar 

  • Liscombe DK, Macleod BP, Loukanina N, Nandi OI, Facchini PJ (2005) Evidence for the monophyletic evolution of benzylisoquinoline alkaloid biosynthesis in angiosperms. Phytochemistry 66:1374–1393

    Article  CAS  PubMed  Google Scholar 

  • Liu J, Ekramoddoullah A, Piggott N, Zamani A (2005) Molecular cloning of a pathogen/wound-inducible PR10 promoter from Pinus monticola and characterization in transgenic Arabidopsis plants. Planta 221:159–169

    Article  CAS  PubMed  Google Scholar 

  • Liu R, Krishnan HB, Xue W, Liu C (2011) Characterization of allergens isolated from the freshwater fish blunt snout bream (Megalobrama amblycephala). J Agric Food Chem 59:458–463

    Article  CAS  PubMed  Google Scholar 

  • Liu CY, Tao S, Xue JY, Zhang H, Xue WT, Chen FS (2014) Identification and purification of a novel fish allergen from largemouth bass (Micropterus salmoides). Food Agric Immunol 25:70–81

    Article  CAS  Google Scholar 

  • Liu F, Zhang X, Lu C, Zeng X, Li Y, Fu D, Wu G (2015) Non-specific lipid transfer proteins in plants: presenting new advances and an integrated functional analysis. J Exp Bot 66:5663–5681. https://doi.org/10.1093/jxb/erv313

    Article  CAS  PubMed  Google Scholar 

  • Lonnerdal B, Lien E (2010) Nutritional and physiologic significance of alpha-lactalbumin in infants. Nutr Rev 61:295–305

    Article  Google Scholar 

  • Lópeztorrejón G, Crespo JF, Sánchezmonge R, Sánchezjiménez M, Alvarez J, Rodriguez J, Salcedo G (2010) Allergenic reactivity of the melon profilin Cuc m 2 and its identification as major allergen. Clin Exp Allergy 35:1065–1072

    Article  CAS  Google Scholar 

  • Ma Y et al (2010) Characterization of recombinant Mal d 4 and its application for component-resolved diagnosis of apple allergy. Clin Exp Allergy 36:1087–1096

    Article  Google Scholar 

  • Mackenzie K, Fitch P, Leech M, Ilchmann A, Wilson C, Mcfarlane A (2013) Combination peptide immunotherapy based on T-cell epitope mapping reduces allergen-specific IgE and eosinophilia in allergic airway inflammation. Immunology 138:258–268

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Maizels R, Clarke J, Harvey M, Miller A, Sercarz E (2010) Epitope specificity of the T cell proliferative response to lysozyme: proliferative T cells react predominantly to different determinants from those recognized by B cells. Eur J Immunol 10:509–515

    Article  Google Scholar 

  • Mao HY, Cao MJ, Maleki SJ, Cai QF, Su WJ, Yang Y, Liu GM (2013) Structural characterization and IgE epitope analysis of arginine kinase from Scylla paramamosain. Mol Immunol 56:463–470

    Article  CAS  PubMed  Google Scholar 

  • Martos G, Pineda-Vadillo C, Miralles B, Alonso-Lebrero E, López-Fandiño R, Molina E, Belloque J (2012) Identification of an IgE reactive peptide in hen egg riboflavin binding protein subjected to simulated gastrointestinal digestion. J Agric Food Chem 60:5215–5220

    Article  CAS  PubMed  Google Scholar 

  • Maruyama N et al (1998) Identification of major wheat allergens by means of the Escherichia coli expression system. Eur J Biochem 255:739–745

    Article  CAS  PubMed  Google Scholar 

  • Matsuo H et al (2004) Identification of the IgE-binding epitope in ω-5 gliadin, a major allergen in wheat-dependent exercise-induced anaphylaxis. J Biol Chem 279:12135–12140

    Article  CAS  PubMed  Google Scholar 

  • Mauch F, Staehelin L (1989) Functional implications of the subcellular localization of ethylene-induced chitinase and [beta]-1,3-glucanase in bean leaves. Plant Cell 1:447–457

    CAS  PubMed  PubMed Central  Google Scholar 

  • Maynard F, Jost R, Wal J (1997) Human IgE binding capacity of tryptic peptides from bovine alpha-lactalbumin. Int Arch Allergy Immunol 113:478–488

    Article  CAS  PubMed  Google Scholar 

  • Mills EN, Jenkins JA, Alcocer MJ, Shewry PR (2004) Structural, biological, and evolutionary relationships of plant food allergens sensitizing via the gastrointestinal tract. Crit Rev Food Sci Nutr 44:379–407

    Article  CAS  PubMed  Google Scholar 

  • Mills E et al (2007) The prevalence, cost and basis of food allergy across. Eur Allergy 62:717–722. https://doi.org/10.1111/j.1398-9995.2007.01425.x

    Article  CAS  Google Scholar 

  • Mine Y, Rupa P (2003) Fine mapping and structural analysis of immunodominant IgE allergenic epitopes in chicken egg ovalbumin. Protein Eng 16:747–752

    Article  CAS  PubMed  Google Scholar 

  • Mine Y, Zhang J (2002) Identification and fine mapping of IgG and IgE epitopes in ovomucoid. Biochem Biophys Res Commun 292:1070–1074

    Article  CAS  PubMed  Google Scholar 

  • Misra A, Kumar R, Mishra V, Chaudhari BP, Tripathi A, Das M, Dwivedi PD (2010) Partial characterization of red gram (Cajanus cajan L. Millsp) polypeptides recognized by patients exhibiting rhinitis and bronchial asthma. Food Chem Toxicol 48:2725–2736

    Article  CAS  PubMed  Google Scholar 

  • Misra A, Kumar R, Mishra V, Chaudhari BP, Raisuddin S, Das M, Dwivedi PD (2011) Potential allergens of green gram (Vigna radiata L. Millsp) identified as members of cupin superfamily and seed albumin. Clin Exp Allergy 41:1157–1168

    Article  CAS  PubMed  Google Scholar 

  • Moreno F, Clemente A (2008) 2S albumin storage proteins: what makes them food allergens? Open Biochem J 2:16–28

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nakase M et al (1996) Cloning of the rice seed alpha-globulin-encoding gene: sequence similarity of the 5′-flanking region to those of the genes encoding wheat high-molecular-weight glutenin and barley D hordein. Gene 170:223–226

    Article  CAS  PubMed  Google Scholar 

  • Nam Y, Tichit L, Leperlier M, Cuerq B, Marty I, Lelièvre J (1999) Isolation and characterization of mRNAs differentially expressed during ripening of wild strawberry (Fragaria vesca L.) fruits. Plant Mol Biol 39:629–636

    Article  CAS  PubMed  Google Scholar 

  • Nessler CL, Allen RD, Galewsky S (1985) Identification and characterization of latex-specific proteins in opium poppy. Plant Physiol 79:499–504

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nisbet AD, Saundry RH, Moir AJ, Fothergill LA, Fothergill JE (2010) The complete amino-acid sequence of hen ovalbumin. Eur J Biochem 115:335–345

    Article  Google Scholar 

  • Osuga DT, Feeney RE (1968) Biochemistry of the egg-white proteins of the ratite group. Arch Biochem Biophys 124:560–574

    Article  CAS  PubMed  Google Scholar 

  • Padlan EA, Silverton EW, Sheriff S, Cohen GH, Smith-Gill SJ, Davies DR (1989) Structure of an antibody-antigen complex: crystal structure of the HyHEL-10 fab-lysozyme complex. Proc Natl Acad Sci U S A 86:5938–5942

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pan BQ, Su WJ, Cao MJ, Cai QF, Weng WY, Liu GM (2012) IgE reactivity to type I collagen and its subunits from tilapia (Tilapia zillii). Food Chem 130:127–133

    Article  CAS  Google Scholar 

  • Pasternak O, Bujacz G, Fujimoto Y, Hashimoto Y, Jelen F, Otlewski J (2006) Crystal structure of Vigna radiata cytokinin-specific binding protein in complex with zeatin. Plant Cell 18:2622–2634

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Pastorello E et al (2003) Lipid-transfer protein is the major maize allergen maintaining IgE-binding activity after cooking at 100 degrees C, as demonstrated in anaphylactic patients and patients with positive double-blind, placebo-controlled food challenge results. J Allergy Clin Immunol 112:775–783

    Article  CAS  PubMed  Google Scholar 

  • Pedrosa M, Boyano-Martínez T, García-Ara C, Quirce S (2015) Shellfish allergy: a comprehensive review. Clin Rev Allergy Immunol 49:1–14

    Article  CAS  Google Scholar 

  • Perlmann GE (1950) Enzymatic dephosphorylation of ovalbumin and plakalbumin. Nature 166:870–871

    Article  CAS  PubMed  Google Scholar 

  • Piboonpocanun S, Jirapongsananuruk O, Tipayanon T, Boonchoo S, Goodman RE (2011) Identification of hemocyanin as a novel non-cross-reactive allergen from the giant freshwater shrimp Macrobrachium rosenbergii. Mol Nutr Food Res 55:1492–1498

    Article  CAS  PubMed  Google Scholar 

  • Poms R, Klein C, Anklam E (2004) Methods for allergen analysis in food: a review. Food Addit Contam 21:1–31. https://doi.org/10.1080/02652030310001620423

    Article  CAS  PubMed  Google Scholar 

  • Radauer C, Breiteneder H (2007) Evolutionary biology of plant food allergens. J Allergy Clin Immunol 120:518–525. https://doi.org/10.1016/j.jaci.2007.07.024

    Article  CAS  PubMed  Google Scholar 

  • Radauer C, Lackner P, Breiteneder H (2008) The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands BMC. Evol Biol 8:286

    Google Scholar 

  • Ren X, Xin Z, Li Y, Wang Z (2010) Epitope mapping and immunological characterization of a major allergen TBa in tartary buckwheat. Biotechnol Lett 32:1317

    Article  CAS  PubMed  Google Scholar 

  • Robotham JM, Hoffman GG, Teuber SS, Beyer K, Sampson HA, Sathe SK, Roux KH (2009) Linear IgE-epitope mapping and comparative structural homology modeling of hazelnut and English walnut 11S globulins. Mol Immunol 46:2975–2984

    Article  CAS  PubMed  Google Scholar 

  • Rona R, Keil T, Summers C, Gislason D, Zuidmeer L, Sodergren E (2007) The prevalence of food allergy: a meta-analysis. J Allergy Clin Immunol 120:638–646

    Article  PubMed  Google Scholar 

  • Rougé P, Culerrier R, Sabatier V, Granier C, Rancé F, Barre A (2009) Mapping and conformational analysis of IgE-binding epitopic regions on the molecular surface of the major Ara h 3 legumin allergen of peanut (Arachis hypogaea). Mol Immunol 46:1067–1075

    Article  PubMed  CAS  Google Scholar 

  • Sampson HA (1992) The immunopathogenic role of food hypersensitivity in atopic dermatitis. Acta Derm Venereol Suppl (Stockh) 176:34–37

    CAS  Google Scholar 

  • Sampson H, Cooke S (1990) Food allergy and the potential allergenicity-antigenicity of microparticulated egg and cow’s milk proteins. J Am Coll Nutr 9:410–417

    Article  CAS  PubMed  Google Scholar 

  • Schenk MF, Gilissen LJ, Esselink GD, Smulders MJ (2006) Seven different genes encode a diverse mixture of isoforms of Bet v 1, the major birch pollen allergen. BMC Genomics 7:168–168

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Sélo I, Clément G, Bernard H, Chatel J, Créminon C, Peltre G, Wal J (2010) Allergy to bovine beta-lactoglobulin: specificity of human IgE to tryptic peptides. Clin Exp Allergy 29:1055–1063

    Article  Google Scholar 

  • Seussbaum I, Nau F, Guérin C (2017) The nutritional quality of eggs. Improving the safety and quality of eggs and egg products, vol 2. Egg safety and nutritional quality

    Google Scholar 

  • Shanti K, Martin B, Nagpal S, Metcalfe D, Rao P (1993) Identification of tropomyosin as the major shrimp allergen and characterization of its IgE-binding epitopes. J Immunol 151:5354

    CAS  PubMed  Google Scholar 

  • Smith-Gill S, Wilson A, Potter M, Prager E, Feldmann R, Mainhart C (1982) Mapping the antigenic epitope for a monoclonal antibody against lysozyme. J Immunol 128:314

    CAS  PubMed  Google Scholar 

  • Spuergin P, Mueller H, Walter M, Schiltz E, Forster J (1996) Allergenic epitopes of bovine αs1-casein recognized by human IgE and IiG. Allergy 51:306

    CAS  PubMed  Google Scholar 

  • Spuergin P, Walter M, Schiltz E, Deichmann K, Forster J, Mueller H (1997) Allergenicity of alpha-caseins from cow, sheep, and goat. Allergy 52:293

    Article  CAS  PubMed  Google Scholar 

  • Stanic-Vucinic D et al (2012) Structural changes and allergenic properties of β-lactoglobulin upon exposure to high-intensity ultrasound. Mol Nutr Food Res 56:1894–1905

    Article  CAS  PubMed  Google Scholar 

  • Strömvik M, Sundararaman V, Vodkin L (1999) A novel promoter from soybean that is active in a complex developmental pattern with and without its proximal 650 base pairs. Plant Mol Biol 41:217–231

    Article  PubMed  Google Scholar 

  • Suzuki M, Kobayashi Y, Hiraki Y, Nakata H, Shiomi K (2011) Paramyosin of the disc abalone Haliotis discus discus: identification as a new allergen and cross-reactivity with tropomyosin. Food Chem 124:921–926

    Article  CAS  Google Scholar 

  • Swoboda I, Scheiner O, Heberle-Bors E, Vicente O (2010) cDNA cloning and characterization of three genes in the Bet v 1 gene family that encode pathogenesis-related proteins. Plant Cell Environ 18:865–874

    Article  Google Scholar 

  • Takagaki Y, Hirayama A, Fujio H, Amano T (1980) Antibodies to a continuous region at residues 38–54 of hen egg white lysozyme found in a small fraction of anti-hen egg white lysozyme antibodies. Biochemistry 19:2498

    Article  CAS  PubMed  Google Scholar 

  • Tanabe S (2004) IgE-binding abilities of pentapeptides, QQPFP and PQQPF, in wheat gliadin. J Nutr Sci Vitaminol 50:367–370

    Article  CAS  PubMed  Google Scholar 

  • Tanabe S, Shibata R, Nishimura T (2004) Hypoallergenic and T cell reactive analogue peptides of bovine serum albumin, the major beef allergen. Mol Immunol 41:885–890

    Article  CAS  PubMed  Google Scholar 

  • Toda M et al (2011) Protein unfolding strongly modulates the allergenicity and immunogenicity of Pru p 3, the major peach allergen. J Allergy Clin Immunol 128:1022–1030.e1027

    Article  CAS  PubMed  Google Scholar 

  • Tyrer S, Mccarthy M, Shopsin B, Schacht R (2002) Recombinant carp parvalbumin, the major cross-reactive fish allergen: a tool for diagnosis and therapy of fish allergy. J Immunol 168:4576–4584

    Article  Google Scholar 

  • Untersmayr E, Poulsen L, Platzer M, Pedersen M, Boltz-Nitulescu G, Skov P, Jensen-Jarolim E (2005) The effects of gastric digestion on codfish allergenicity. J Allergy Clin Immunol 115:377–382

    Article  CAS  PubMed  Google Scholar 

  • Untersmayr E et al (2006) Mimotopes identify conformational epitopes on parvalbumin, the major fish allergen. Mol Immunol 43:1454–1461

    Article  CAS  PubMed  Google Scholar 

  • Van LL, Rep M, Pieterse C (2006) Significance of inducible defense-related proteins in infected plants. Annu Rev Phytopathol 44:135–162

    Article  CAS  Google Scholar 

  • Vieths S, Scheurer S, Ballmerweber B (2010) Current understanding of cross-reactivity of food allergens and pollen. Ann N Y Acad Sci 964:47–68

    Article  Google Scholar 

  • Vila L, Beyer K, Järvinen K, Chatchatee P, Bardina L, Sampson H (2010) Role of conformational and linear epitopes in the achievement of tolerance in cow’s milk allergy. Clin Exp Allergy 31:1599–1606

    Article  Google Scholar 

  • Wal J (1998) Cow’s milk allergens. Allergy 53:1013–1022

    Article  CAS  PubMed  Google Scholar 

  • Wal J (2002) Cow’s milk proteins/allergens. Ann Allergy Asthma Immunol 89:3–10

    Article  CAS  PubMed  Google Scholar 

  • Wang C, Huang J, Hu J (1999) Characterization of two subclasses of PR-10 transcripts in lily anthers and induction of their genes through separate signal transduction pathways. Plant Mol Biol 40:807–814

    Article  CAS  PubMed  Google Scholar 

  • Wang B, Zhenxing L, Zheng L, Liu Y, Hong L (2011) Identification and characterization of a new IgE-binding protein in mackerel (Scomber japonicus) by MALDI-TOF-MS. J Ocean Univ China 10:93–98

    Article  CAS  Google Scholar 

  • Wen J, Vanekkrebitz M, Hoffmannsommergruber K, Scheiner O, Breiteneder H (1997) The potential of Betv1 homologues, a nuclear multigene family, as phylogenetic markers in flowering plants. Mol Phylogenet Evol 8:317–333

    Article  CAS  PubMed  Google Scholar 

  • Williams J, Elleman T, Kingston I, Wilkins A, Kuhn K (2010) The primary structure of hen ovotransferrin. FEBS J 122:297–303

    Google Scholar 

  • Woo EJ, Marshall J, Bauly J, Chen JG, Venis M, Napier RM, Pickersgill RW (2014) Crystal structure of auxin-binding protein 1 in complex with auxin. EMBO J 21:2877–2885

    Article  Google Scholar 

  • Yagami T, Osuna H, Kouno M, Haishima Y, Nakamura A, Ikezawa Z (2002) Significance of carbohydrate epitopes in a latex allergen with beta-1,3-glucanase activity. Int Arch Allergy Immunol 129:27–37

    Article  CAS  PubMed  Google Scholar 

  • Yamashita K, Kamerling JP, Kobata A (1982) Structural study of the carbohydrate moiety of hen ovomucoid. Occurrence of a series of pentaantennary complex-type asparagine-linked sugar chains. J Biol Chem 257:12809

    CAS  PubMed  Google Scholar 

  • Yet M, Chin C, Wold F (1988) The covalent structure of individual N-linked glycopeptides from ovomucoid and asialofetuin. J Biol Chem 263:111

    CAS  PubMed  Google Scholar 

  • Yoshida S, Ichimura A, Shiomi K (2008) Elucidation of a major IgE epitope of Pacific mackerel parvalbumin. Food Chem 111:857–861

    Article  CAS  Google Scholar 

  • Yu X, Ekramoddoullah A, Misra S (2000) Characterization of Pin m III cDNA in western white pine tree. Physiology 20:663–671

    CAS  Google Scholar 

  • Yu C, Lin Y, Chiang B, Chow L (2003) Proteomics and immunological analysis of a novel shrimp allergen, Pen m 2. J Immunol 170:445–453

    Article  CAS  PubMed  Google Scholar 

  • Zheng L, Lin H, Pawar R, Li Z, Li M (2011) Mapping IgE binding epitopes of major shrimp (Penaeus monodon) allergen with immunoinformatics tools. Food Chem Toxicol 49:2954–2960

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. School of Food Science and Biotechnology, Zhejiang Gongshang University, Hanghzou, China

    Linglin Fu & Yanbo Wang

  2. Mucosal Immunology and Biology Research, Harvard Medical School, Charlestown, MA, USA

    Bobby J. Cherayil & Haining Shi

  3. Bioprocess Engineering Group, Agrotechnology and Food Sciences, Wageningen University and Research, Wageningen, The Netherlands

    Yang Zhu

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  1. Linglin Fu
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  2. Bobby J. Cherayil
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  3. Haining Shi
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  4. Yanbo Wang
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  5. Yang Zhu
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Fu, L., Cherayil, B.J., Shi, H., Wang, Y., Zhu, Y. (2019). Species and Structure of Food Allergens: Epitopes and Cross-Reactivity. In: Food Allergy. Springer, Singapore. https://doi.org/10.1007/978-981-13-6928-5_2

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