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Liver Disorders in Systemic Diseases

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Abstract

Liver disease may occur in association with various systemic diseases. These primary diseases are predominantly extrahepatic, but associated hepatic dysfunction may develop and often is of clinical significance and diagnostic importance. In some cases, liver disease simply represents a manifestation of the systemic disease process involving the liver, as in disseminated malignancy, systemic infection, and some metabolic diseases. Rarely, it may constitute a relatively unique manifestation of a systemic disease, as in primary sclerosing cholangitis associated with ulcerative colitis.

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Abbreviations

AIDS:

Acquired immunodeficiency syndrome

ANC:

Absolute neutrophil count

C-MOPP-ABVD:

Combination chemotherapy-Mustargen, oncovin, procarbazine, prednisone-Adriamycin, bleomycin, vinblastine, dacarbazine

CREST:

Calcinosis cutis, Raynaud’s phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia

DIC:

Disseminated intravascular coagulopathy

EMH:

Extramedullary hemopoiesis

HELLP:

Hemolysis, elevated liver tests, and low platelets

IBD:

Inflammatory bowel disease

MALT:

Mucosa-associated lymphoid tissue

MDR3:

Multidrug resistance protein 3

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Author information

Authors and Affiliations

  1. Kyoto, Japan

    Masaki Iwai MD, PhD

  2. Tottori, Japan

    Kenichi Miyoshi MD, PhD & Masahiko Koda MD, PhD

  3. Hong Kong, China

    Wilson M. S. Tsui MD, FRCPath

Authors
  1. Masaki Iwai MD, PhD
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  2. Kenichi Miyoshi MD, PhD
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  3. Masahiko Koda MD, PhD
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  4. Wilson M. S. Tsui MD, FRCPath
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Corresponding author

Correspondence to Wilson M. S. Tsui MD, FRCPath .

Editor information

Editors and Affiliations

  1. Department of Gastroenterology & Hepatology, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan

    Etsuko Hashimoto

  2. Department of Gastroenterology/Hepatology, Stanford University School of Medicine, Palo Alto, CA, USA

    Paul Y. Kwo

  3. Department of Pathology and Laboratory Medicine, Dartmouth–Hitchcock Medical Center, Lebanon, NH, USA

    Arief A. Suriawinata

  4. Department of Pathology, Caritas Medical Center, Kowloon, Hong Kong, China

    Wilson M.S. Tsui

  5. Division of Gastroenterology, Hepatology & Internal Medicine, Iwai Clinic, Kamigyo-ku, Kyoto, Japan

    Masaki Iwai

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Iwai, M., Miyoshi, K., Koda, M., Tsui, W.M.S. (2019). Liver Disorders in Systemic Diseases. In: Hashimoto, E., Kwo, P., Suriawinata, A., Tsui, W., Iwai, M. (eds) Diagnosis of Liver Disease. Springer, Singapore. https://doi.org/10.1007/978-981-13-6806-6_15

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  • DOI: https://doi.org/10.1007/978-981-13-6806-6_15

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  • Publisher Name: Springer, Singapore

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  • Online ISBN: 978-981-13-6806-6

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