Abstract
Mushrooms have various bioactive compounds, which have anticancer, antibacterial, antifungal, antiviral, antioxidant, and anti-inflammatory compounds. The limitation of natural antiviral compounds in the market and the viruses becoming resistant to currently available antivirals warranted the need for new antivirals with fewer side effects. Although many different compounds from various mushrooms (both edible and nonedible) have been isolated and shown to have antiviral effects, successful introduction of a new antiviral to the market requires extensive studies and clinical trials. Antiviral compounds isolated from the mushrooms have shown potential activity against prominent viruses such as human immunodeficiency virus, influenza, herpes simplex virus, hepatitis B and C viruses, etc. State of the art suggests more in-depth exploration of mushrooms for more potent antivirals and other lifesaving drugs.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Abbreviations
- AZT:
-
Zidovudine
- DNA:
-
Deoxyribonucleic acid
- EBV:
-
Epstein-Barr virus
- EMCV:
-
Encephalomyocarditis virus
- FMDV:
-
Foot-and-mouth disease virus
- GLPG:
-
Ganoderma lucidum proteoglycan
- GLTA:
-
Ganoderma lucidum triterpenoids Lanosta-7,9(11),24-trien-3-one,15;26- dihydroxy
- HBV:
-
Hepatitis B virus
- HCV:
-
Hepatitis C virus
- HIV:
-
Human immunodeficiency virus
- HSV:
-
Herpes simplex virus
- JLS:
-
Water-soluble lignin-rich fraction
- KS-2:
-
Extract from culture mycelia of Lentinus edodes
- LAC:
-
Laccase
- NA:
-
Neuraminidase
- NDV:
-
Newcastle disease virus
- RNA:
-
Ribonucleic acid
- RSV:
-
Respiratory syncytial virus
- RT:
-
Reverse transcriptase
- sAAP:
-
Sulfated Auricularia auricula polysaccharides
- VSV:
-
Vesicular stomatitis virus
- VZV:
-
Varicella zoster virus
References
Akihisa T, Franzblau SG, Tokuda H et al (2005) Antitubercular activity and inhibitory effect on Epstein-Barr virus activation of sterols and polyisoprenepolyols from an edible mushroom, Hypsizygus marmoreus. Biol Pharm Bull 28:1117–1119. https://doi.org/10.1248/bpb.28.1117
Awadh ANA, Mothana RA, Lesnau A et al (2003) Antiviral activity of Inonotus hispidus. Fitoterapia 74:483–485. https://doi.org/10.1016/S0367-326X(03)00119-9
Cardozo FT, Camelini CM, Mascarello A et al (2011) Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia. Antivir Res 92:108–114. https://doi.org/10.1016/j.antiviral.2011.07.009
Cardozo FT, Larsen IV, Carballo EV et al (2013) In vivo anti-herpes simplex virus activity of a sulfated derivative of Agaricus brasiliensis mycelial polysaccharide. Antimicrob Agents Chemother 57:2541–2549. https://doi.org/10.1128/AAC.02250-12
Cardozo FT, Camelini CM, Leal PC et al (2014) Antiherpetic mechanism of a sulfated derivative of Agaricus brasiliensis fruiting bodies polysaccharide. Intervirology 57:375–383. https://doi.org/10.1159/000365194
Chang ST, Buswell JA (1996) Mushroom nutriceuticals. World J Microbiol Biotechnol 12:473–476. https://doi.org/10.1007/BF00419460
Chen L, Shao HJ (2006) Extract from Agaricus blazei Murill can enhance immune responses elicited by DNA vaccine against foot-and-mouth disease. Vet Immunol Immunopathol 109:177–182. https://doi.org/10.1016/j.vetimm.2005.08.028
Chen WC, Wang SY, Chiu CC et al (2013) Lucidone suppresses hepatitis c virus replication by Nrf2-mediated heme oxygenase-1 induction. Antimicrob Agents Chemother 57:1180–1191. https://doi.org/10.1128/AAC.02053-12
Dao TT, Nguyen PH, Lee HS et al (2011) Chalcones as novel influenza A (H1N1) neuraminidase inhibitors from Glycyrrhiza inflata. Bioorg Med Chem Lett 21:294–298. https://doi.org/10.1016/j.bmcl.2010.11.016
De Clercq E (1996) Chemotherapy of viral infections. In: Medical microbiology, 4th edn. University of Texas Medical Branch, Galveston
De Clercq E, Li G (2016) Approved antiviral drugs over the past 50 years. Clin Microbiol Rev 29:695–747. https://doi.org/10.1128/CMR.00102-15
De Leo A, Arena G, Lacanna E et al (2012) Resveratrol inhibits Epstein Barr virus lytic cycle in Burkitt’s lymphoma cells by affecting multiple molecular targets. Antivir Res 96:196–202. https://doi.org/10.1016/j.antiviral.2012.09.003
Ding Y, Seow SV, Huang CH et al (2009) Coadministration of the fungal immunomodulatory protein FIP-Fve and a tumour-associated antigen enhanced antitumour immunity. Immunology 128:881–894. https://doi.org/10.1111/j.1365–2567.2009.03099.x
Drugs.com; Available via: https://www.drugs.com/drug-class/antiviral-agents.html
El Dine RS, El Halawany AM, Ma CM, Hattori M (2008) Anti-HIV-1 protease activity of lanostane triterpenes from the Vietnamese mushroom Ganoderma colossum. J Nat Prod 71:1022–1026. https://doi.org/10.1021/np8001139
El-Fakharany EM, Haroun BM, Ng TB, Redwan ER (2010) Oyster mushroom laccase inhibits hepatitis C virus entry into peripheral blood cells and hepatoma cells. Protein Pept Lett 17:1031–1039. https://doi.org/10.2174/092986610791498948
Eo SK, Kim YS, Lee CK, Han SS (2000) Possible mode of antiviral activity of acidic protein bound polysaccharide isolated from Ganoderma lucidum on herpes simplex viruses. J Ethnopharmacol 72:475–481. https://doi.org/10.1016/S0378-8741(00)00266-X
Eo SK, Kim YS, Oh KW et al (2001) Mode of antiviral activity of water soluble components isolated from Elfvingia applanata on vesicular stomatitis virus. Arch Pharm Res 24:74–78
Faccin LC, Benati F, Rincão VP et al (2007) Antiviral activity of aqueous and ethanol extracts and of an isolated polysaccharide from Agaricus brasiliensis against poliovirus type 1. Lett Appl Microbiol 45:24–28. https://doi.org/10.1111/j.1472-765X.2007.02153.x
Férir G, Palmer KE, Schols D (2011) Synergistic activity profile of griffithsin in combination with tenofovir, maraviroc and enfuvirtide against HIV-1 clade C. Virology 417:253–258. https://doi.org/10.1016/j.virol.2011.07.004
Friedman M (2016) Mushroom polysaccharides: chemistry and antiobesity, antidiabetes, anticancer, and antibiotic properties in cells, rodents, and humans. Foods 5:80. https://doi.org/10.3390/foods5040080
Gao W, Sun Y, Chen S et al (2013) Mushroom lectin enhanced immunogenicity of HBV DNA vaccine in C57BL/6 and HBsAg-transgenic mice. Vaccine 31:2273–2280. https://doi.org/10.1016/j.vaccine.2013.02.062
Gao L, Sun Y, Si J et al (2014) Cryptoporus volvatus extract inhibits influenza virus replication in vitro and in vivo. PLoS One 9:e113604. https://doi.org/10.1371/journal.pone.0113604
Gong M, Piraino F, Yan N et al (2009) Purification, partial characterization and molecular cloning of the novel antiviral protein RC28. Peptides 30:654–659. https://doi.org/10.1016/j.peptides.2008.11.016
Grienke U, Schmidtke M, Kirchmair J et al (2010) Antiviral potential and molecular insight into neuraminidase inhibiting diarylheptanoids from Alpinia katsumadai. J Med Chem 53:778–786. https://doi.org/10.1021/jm901440f
Gu CQ, Li JW, Chao FH (2006) Inhibition of hepatitis B virus by D-fraction from Grifola frondosa: Synergistic effect of combination with interferon-α in HepG2 2.2.15. Antivir Res 72:162–165. https://doi.org/10.1016/j.antiviral.2006.05.011
Gu CQ, Li JW, Chao F et al (2007) Isolation, identification and function of a novel anti-HSV-1 protein from Grifola frondosa. Antivir Res 75:250–257. https://doi.org/10.1016/j.antiviral.2007.03.011
Han CH, Zhang GQ, Wang HX, Ng TB (2010) Schizolysin, a hemolysin from the split gill mushroom Schizophyllum commune. FEMS Microbiol Lett 309:115–121. https://doi.org/10.1111/j.1574-6968.2010.02022.x
Hassan MAA, Rouf R, Tiralongo E et al (2015) Mushroom lectins: specificity, structure and bioactivity relevant to human disease. Int J Mol Sci 16:7802–7838. https://doi.org/10.3390/ijms16047802
Heredia A, Davis C, Redfield R (2000) Synergistic inhibition of HIV-1 in activated and resting peripheral blood mononuclear cells, monocyte-derived macrophages, and selected drug-resistant isolates with nucleoside analogues combined with a natural product, resveratrol. J Acquir Immune Defic Syndr 25:246–255. https://doi.org/10.1097/00126334-200011010-00006
Hijikata Y, Yamada S, Yasuhara A (2007) Herbal mixtures containing the mushroom Ganoderma lucidum improve recovery time in patients with herpes genitalis and labialis. J Altern Complement Med 13:985–987. https://doi.org/10.1089/acm.2006.6297
Hsu C-H, Hwang K-C, Chiang Y-H, Chou P (2008) The mushroom Agaricus blazei Murill extract normalizes liver function in patients with chronic hepatitis B. J Altern Complement Med 14:299–301. https://doi.org/10.1089/acm.2006.6344
Hwang BS, Lee IK, Choi HJ, Yun BS (2015) Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii. Bioorg Med Chem Lett 25:3256–3260. https://doi.org/10.1016/j.bmcl.2015.05.081
Ichimura T, Watanabe O, Maruyama S (1998) Inhibition of HIV-1 protease by water-soluble lignin-like substance from an edible mushroom, Fuscoporia obliqua. Biosci Biotechnol Biochem 62:575–577. https://doi.org/10.1271/bbb.62.575
Ichinohe T, Ainai A, Nakamura T et al (2010) Induction of cross-protective immunity against influenza A virus H5N1 by an intranasal vaccine with extracts of mushroom mycelia. J Med Virol 82:128–137. https://doi.org/10.1002/jmv.21670
Jacobson JM, Feinman L, Liebes L et al (2001) Pharmacokinetics, safety, and antiviral effects of hypericin, a derivative of St. John’s wort plant, in patients with chronic hepatitis C virus infection. Antimicrob Agents Chemother 45:517–524. https://doi.org/10.1128/AAC.45.2.517
Jiang ZY, Liu WF, Zhang XM et al (2013) Anti-HBV active constituents from Piper longum. Bioorg Med Chem Lett 23:2123–2127. https://doi.org/10.1016/j.bmcl.2013.01.118
Johnson E, Førland DT, Sætre L et al (2009) Effect of an extract based on the medicinal mushroom Agaricus blazei murill on release of cytokines, chemokines and leukocyte growth factors in human blood ex vivo and in vivo. Scand J Immunol 69:242–250. https://doi.org/10.1111/j.1365-3083.2008.02218.x
Kanokmedhakul S, Kanokmedhakul K, Prajuabsuk T et al (2003) A bioactive triterpenoid and vulpinic acid derivatives from the mushroom Scleroderma citrinum. Planta Med 69:568–571. https://doi.org/10.1055/s-2003-40639
Kara Rogers, Encyclopaedia Britannica (1999). https://www.britannica.com/science/mushroom
Kotwal GJ (2008) Genetic diversity-independent neutralization of pandemic viruses (e.g. HIV), potentially pandemic (e.g. H5N1 strain of influenza) and carcinogenic (e.g. HBV and HCV) viruses and possible agents of bioterrorism (variola) by enveloped virus neutralizing com. Vaccine 26:3055–3058. https://doi.org/10.1016/j.vaccine.2007.12.008
Kotwal GJ, Kaczmarek JN, Leivers S et al (2005) Anti-HIV, anti-poxvirus, and anti-SARS activity of a nontoxic, acidic plant extract from the Trifolium species Secomet-V/anti-Vac suggests that it contains a novel broad-spectrum antiviral. Ann N Y Acad Sci 1056:293–302. https://doi.org/10.1196/annals.1352.014
Krupodorova T, Rybalko S, Barshteyn V (2014) Antiviral activity of Basidiomycete mycelia against influenza type A (serotype H1N1) and herpes simplex virus type 2 in cell culture. Virol Sin 29:284–290. https://doi.org/10.1007/s12250-014-3486-y
Lee IH, Huang R-L, Chen C-T et al (2002) Antrodia camphorata polysaccharides exhibit anti-hepatitis B virus effects. FEMS Microbiol Lett 209:63–67. https://doi.org/10.1111/j.1574-6968.2002.tb11110.x
Lee CL, Chiang LC, Cheng LH et al (2009) Influenza A (H1N1) antiviral and cytotoxic agents from Ferula assa-foetida. J Nat Prod 72:1568–1572. https://doi.org/10.1021/np900158f
Lee S, Il KJ, Heo J et al (2013) The anti-influenza virus effect of Phellinus igniarius extract. J Microbiol 51:676–681. https://doi.org/10.1007/s12275-013-3384-2
Lehmann VKB, Huang A, Ibanez-Calero S et al (2003) Illudin S, the sole antiviral compound in mature fruiting bodies of Omphalotus illudens. J Nat Prod 66:1257–1258. https://doi.org/10.1021/np030205w
Li YQ, Wang SF (2006) Anti-hepatitis B activities of ganoderic acid from Ganoderma lucidum. Biotechnol Lett 28:837–841. https://doi.org/10.1007/s10529-006-9007-9
Li YQ, Zhang KC (2005) In vitro inhibitory effects on HBsAg and HBeAg secretion of 3 new components produced by Ganoderma lucidum in the medium contained Radix sophorae flavescentis extract. Wei Sheng Wu Xue Bao 45:643–646
Li YR, Liu QH, Wang HX, Ng TB (2008) A novel lectin with potent antitumor, mitogenic and HIV-1 reverse transcriptase inhibitory activities from the edible mushroom Pleurotus citrinopileatus. Biochim Biophys Acta, Gen Subj 1780:51–57. https://doi.org/10.1016/j.bbagen.2007.09.004
Li N, Li L, Fang JC et al (2012) Isolation and identification of a novel polysaccharide–peptide complex with antioxidant, anti-proliferative and hypoglycaemic activities from the abalone mushroom. Biosci Rep 32:221–228. https://doi.org/10.1042/BSR20110012
Lindequist U, Niedermeyer THJ, Jülich WD (2005) The pharmacological potential of mushrooms. Evid Based Complement Alternat Med 2:285–299. https://doi.org/10.1093/ecam/neh107
Lindequist U, Jülich WD, Witt S (2015) Ganoderma pfeifferi – A European relative of Ganoderma lucidum. Phytochemistry 114:102–108. https://doi.org/10.1016/j.phytochem.2015.02.018
Liu J, Yang F, Ye LB et al (2004) Possible mode of action of antiherpetic activities of a proteoglycan isolated from the mycelia of Ganoderma lucidum in vitro. J Ethnopharmacol 95:265–272. https://doi.org/10.1016/j.jep.2004.07.010
Ma L-B, Xu B-Y, Huang M et al (2017) Adjuvant effects mediated by the carbohydrate recognition domain of Agrocybe aegerita lectin interacting with avian influenza H9N2 viral surface glycosylated proteins. J Zhejiang Univ Sci B 18:653–661. https://doi.org/10.1631/jzus.B1600106
Matsuhisa K, Yamane S, Okamoto T et al (2015) Anti-HCV effect of Lentinula edodes mycelia solid culture extracts and low-molecular-weight lignin. Biochem Biophys Res Commun 462:52–57. https://doi.org/10.1016/j.bbrc.2015.04.104
Medicinenet.com; Available via: https://www.medicinenet.com/script/main/art.asp?articlekey=10211
Mizerska-Dudka M, Jaszek M, Błachowicz A et al (2015) Fungus Cerrena unicolor as an effective source of new antiviral, immunomodulatory, and anticancer compounds. Int J Biol Macromol 79:459–468. https://doi.org/10.1016/j.ijbiomac.2015.05.015
Neurath AR, Strick N, Li YY, Debnath AK (2005) Punica granatum (pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide. Ann N Y Acad Sci 4:41. https://doi.org/10.1196/annals.1352.015
Ng TB (1998) A review of research on the protein-bound polysaccharide (polysaccharopeptide, PSP) from the mushroom Coriolus versicolor (basidiomycetes: Polyporaceae). Gen Pharmacol 12:473–476. https://doi.org/10.1016/S0306-3623(97)00076-1
Nguyen TL, Chen J, Hu Y et al (2012) In vitro antiviral activity of sulfated Auricularia auricula polysaccharides. Carbohydr Polym 90:1254–1258. https://doi.org/10.1016/j.carbpol.2012.06.060
Nogusa S, Gerbino J, Ritz BW (2009) Low-dose supplementation with active hexose correlated compound improves the immune response to acute influenza infection in C57BL/6 mice. Nutr Res 29:139–143. https://doi.org/10.1016/j.nutres.2009.01.005
Oyetayo OV (2011) Medicinal uses of mushrooms in Nigeria: Towards full and sustainable exploitation. Afr J Tradit Complement Altern Med 8:267–274. https://doi.org/10.4314/ajtcam.v8i3.65289
Pan H, Yu X, Li T et al (2013) Aqueous extract from a Chaga medicinal mushroom, Inonotus obliquus (higher Basidiomyetes), prevents Herpes simplex virus entry through inhibition of viral-induced membrane fusion. Intl J Med Mushrooms 15:29–38. https://doi.org/10.1615/IntJMedMushr.v15.i1.40
Park SH, Song JH, Kim T et al (2012) Anti-human rhinoviral activity of polybromocatechol compounds isolated from the Rhodophyta, Neorhodomela aculeate. Marine Drugs 10:2222–2233. https://doi.org/10.3390/md10102222
Piraino F, Brandt CR (1999) Isolation and partial characterization of an antiviral, RC-183, from the edible mushroom Rozites caperata. Antivir Res 43:67–78. https://doi.org/10.1016/S0166-3542(99)00035-2
Polkovnikova MV, Nosik NN, Garaev TM et al (2014) A study of the antiherpetic activity of the Chaga mushroom (Inonotus obliquus) extracts in the Vero cells infected with the herpes simplex virus. Vopr Virusol 59:45–48
Rincão VP, Yamamoto KA, Silva Ricardo NMP et al (2012) Polysaccharide and extracts from Lentinula edodes: structural features and antiviral activity. Virol J 9:37. https://doi.org/10.1186/1743-422X-9-37
Saboulard D, Gaspar A, Roussel B, Villard J (1998) New antiherpetic nucleoside from a Basidiomycete. C R Acad Sci III 321:585–591. https://doi.org/10.1016/S0764-4469(98)80461-7
Sarkar S, Koga J, Whitley RJ, Chatterjee S (1993) Antiviral effect of the extract of culture medium of Lentinus edodes mycelia on the replication of herpes simplex virus type 1. Antivir Res 20:293–303. https://doi.org/10.1016/0166-3542(93)90073-R
Shibnev VA, Garaev TM, Finogenova MP et al (2015) Antiviral activity of aqueous extracts of the birch fungus Inonotus obliquus on the human immunodeficiency virus. Vopr Virusol 60:35–38
Shin H-B, Choi M-S, Ryu B et al (2013) Antiviral activity of carnosic acid against respiratory syncytial virus. Virol J 10:303. https://doi.org/10.1186/1743-422X-10-303
Song AR, Le SX, Kong C et al (2014) Discovery of a new sesquiterpenoid from Phellinus ignarius with antiviral activity against influenza virus. Arch Virol 159:753–760. https://doi.org/10.1007/s00705-013-1857-6
Sorimachi K, Ikehara Y, Maezato G et al (2001) Inhibition by Agaricus blazei Murill fractions of cytopathic effect induced by Western Equine Encephalitis (WEE) virus on VERO cells in vitro. Biosci Biotechnol Biochem 65:1645–1647. https://doi.org/10.1271/bbb.65.1645
Sun J, Wang H, Ng TB (2011) Isolation of a laccase with HIV-1 reverse transcriptase inhibitory activity from fresh fruiting bodies of the Lentinus edodes (Shiitake mushroom). Indian J Biochem Biophys 48:88–94
Sundararajan A, Ganapathy R, Huan L et al (2010) Influenza virus variation in susceptibility to inactivation by pomegranate polyphenols is determined by envelope glycoproteins. Antivir Res 88:1–9. https://doi.org/10.1016/j.antiviral.2010.06.014
Suzuki F, Suzuki C, Shimomura E et al (1979) Antiviral and interferon-inducing activities of a new peptidomannan, KS-2, extracted from culture mycelia of Lentinus edodes. J Antibiot 32:1336–1345. https://doi.org/10.7164/antibiotics.32.1336
Suzuki H, Iiyama K, Yoshida O, Yamazaki S, Yamamoto N, Toda S (1990) Structural characterization of the immunoactive and antiviral water-solubilized lignin in an extract of the culture medium of Lentinus edodes mycelia (LEM). Agric Biol Chem 54:479–487
Takebe Y, Saucedo CJ, Lund G et al (2013) Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against Hepatitis C virus. PLoS One 8:e64449. https://doi.org/10.1371/journal.pone.0064449
Teplyakova TV, Psurtseva NV, Kosogova TA et al (2012) Antiviral activity of polyporoid mushrooms (higher Basidiomycetes) from Altai mountains (Russia). Intl J Med Mushrooms 14:37–45. https://doi.org/10.1615/IntJMedMushr.v14.i1.40
Tian J, Hu X, Liu D et al (2017) Identification of Inonotus obliquus polysaccharide with broad-spectrum antiviral activity against multi-feline viruses. Int J Biol Macromol 95:160–167. https://doi.org/10.1016/j.ijbiomac.2016.11.054
Tochikura TS, Nakashima H, Ohashi Y, Yamamoto N (1988) Inhibition (in vitro) of replication and of the cytopathic effect of human immunodeficiency virus by an extract of the culture medium of Lentinus edodes mycelia. Med Microbiol Immunol 177:235–244. https://doi.org/10.1007/BF00189409
Van Rensburg CEJ, Gandy JJ, Snyman JR (2010) An observational trial: patient profile of users of Secomet V. S Afr Fam Pract 52:165. http://hdl.handle.net/2263/16819
Wang HX, Ng TB (2000) Isolation of a novel ubiquitin-like protein from Pleurotus ostreatus mushroom with anti-human immunodeficiency virus, translation-inhibitory, and ribonuclease activities. Biochem Biophys Res Commun 276:587–593. https://doi.org/10.1006/bbrc.2000.3540
Wang HX, Ng TB (2004a) A new laccase from dried fruiting bodies of the monkey head mushroom Hericium erinaceum. Biochem Biophys Res Commun 322:17–21. https://doi.org/10.1016/j.bbrc.2004.07.075
Wang HX, Ng TB (2004b) Purification of a novel low-molecular-mass laccase with HIV-1 reverse transcriptase inhibitory activity from the mushroom Tricholoma giganteum. Biochem Biophys Res Commun 315:450–454. https://doi.org/10.1016/j.bbrc.2004.01.064
Wang HX, Ng TB (2006a) A laccase from the medicinal mushroom Ganoderma lucidum. Appl Microbiol Biotechnol 72:508–513. https://doi.org/10.1016/j.jsv.2005.04.011
Wang HX, Ng TB (2006b) Purification of a laccase from fruiting bodies of the mushroom Pleurotus eryngii. Appl Microbiol Biotechnol 69:521–525. https://doi.org/10.1007/s00253-005-0086-7
Wang J, Wang HX, Ng TB (2007) A peptide with HIV-1 reverse transcriptase inhibitory activity from the medicinal mushroom Russula paludosa. Peptides 28:560–565. https://doi.org/10.1016/j.peptides.2006.10.004
Wang K-C, Chang J-S, Lin L-T et al (2012) Antiviral effect of cimicifugin from Cimicifuga foetida against human respiratory syncytial virus. Am J Chin Med 40:1033–1045. https://doi.org/10.1142/S0192415X12500760
Wasser SP (2010) Medicinal mushroom science: History, current status, future trends, and unsolved problems. Intl J Med Mushrooms 12:1–16. https://doi.org/10.1615/IntJMedMushr.v12.i1.10
Wasser SP (2017) Medicinal mushrooms in human clinical studies. Part I. Anticancer, oncoimmunological, and Immunomodulatory activities: a review. Intl J Med Mushrooms 19:279–317. https://doi.org/10.1615/IntJMedMushrooms.v19.i4.10
Wong JH, Wang HX, Ng TB (2008) Marmorin, a new ribosome inactivating protein with antiproliferative and HIV-1 reverse transcriptase inhibitory activities from the mushroom Hypsizygus marmoreus. Appl Microbiol Biotechnol 81:669–674. https://doi.org/10.1007/s00253-008-1639-3
Wong JH, Wang H, Ng TB (2009) A haemagglutinin from the medicinal fungus Cordyceps militaris. Biosci Rep 29:321–327. https://doi.org/10.1042/BSR20080153
Wu YY, Wang HX, Ng TB (2011) A novel metalloprotease from the wild Basidiomycete mushroom Lepista nuda. J Microbiol Biotechnol 21:256–262. https://doi.org/10.4014/jmb.1010.10060
Wu SF, Lin CK, Chuang YS et al (2012) Anti-hepatitis C virus activity of 3-hydroxy caruilignan C from Swietenia macrophylla stems. J Viral Hepat 19:364–370. https://doi.org/10.1111/j.1365-2893.2011.01558.x
Wu Y, Li S, Li H et al (2016) Effect of a polysaccharide from Poria cocos on humoral response in mice immunized by H1N1 influenza and HBsAg vaccines. Int J Biol Macromol 91:248–257. https://doi.org/10.1016/j.ijbiomac.2016.05.046
Xu J, Wang J, Deng F et al (2008) Green tea extract and its major component epigallocatechin gallate inhibits hepatitis B virus in vitro. Antivir Res 78:242–249. https://doi.org/10.1016/j.antiviral.2007.11.011
Yamamoto Y, Shirono H, Kono K, Ohashi Y (1997) Immunopotentiating activity of the water-soluble lignin rich fraction prepared from LEM – the extract of the solid culture medium of Lentinus edodes mycelia. Biosci Biotechnol Biochem 61:1909–1912. https://doi.org/10.1271/bbb.61.1909
Yan N, He F, Piraino F et al (2015) Antiviral activity of a cloned peptide RC28 isolated from the higher basidiomycetes mushroom Rozites caperata in a mouse model of HSV-1 keratitis. Intl J Med Mushrooms 17:819–828. https://doi.org/10.1615/IntJMedMushrooms.v17.i9.20
Zhang GQ, Sun J, Wang HX, Ng TB (2009) A novel lectin with antiproliferative activity from the medicinal mushroom Pholiota adiposa. Acta Biochim Pol 56:415–421. doi: 20091798 [pii]
Zhang Y, Liu Y-B, Li Y et al (2013) Sesquiterpenes and alkaloids from the roots of Alangium chinense. J Nat Prod 76:1058–1063. https://doi.org/10.1021/np4000747
Zhang R, Zhao L, Wang H, Ng TB (2014a) A novel ribonuclease with antiproliferative activity toward leukemia and lymphoma cells and HIV-1 reverse transcriptase inhibitory activity from the mushroom, Hohenbuehelia serotina. Int J Mol Med 33:209–214. https://doi.org/10.3892/ijmm.2013.1553
Zhang W, Tao J, Yang X et al (2014b) Antiviral effects of two Ganoderma lucidum triterpenoids against enterovirus 71 infection. Biochem Biophys Res Commun 449:307–312. https://doi.org/10.1016/j.bbrc.2014.05.019
Zhao JK, Wang HX, Ng TB (2009) Purification and characterization of a novel lectin from the toxic wild mushroom Inocybe umbrinella. Toxicon 53:360–366. https://doi.org/10.1016/j.toxicon.2008.12.009
Zhao S, Zhao Y, Li S et al (2010) A novel lectin with highly potent antiproliferative and HIV-1 reverse transcriptase inhibitory activities from the edible wild mushroom Russula delica. Glycoconj J 27:259–265. https://doi.org/10.1007/s10719-009-9274-5
Zhao X, Hu Y, Wang D et al (2011) Optimization of sulfated modification conditions of Tremella polysaccharide and effects of modifiers on cellular infectivity of NDV. Int J Biol Macromol 49:44–49. https://doi.org/10.1016/j.ijbiomac.2011.03.010
Zhao C, Gao L, Wang C et al (2016) Structural characterization and antiviral activity of a novel heteropolysaccharide isolated from Grifola frondosa against enterovirus 71. Carbohydr Polym 144:382–389. https://doi.org/10.1016/j.carbpol.2015.12.005
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Pradeep, P., Manju, V., Ahsan, M.F. (2019). Antiviral Potency of Mushroom Constituents. In: Agrawal, D., Dhanasekaran, M. (eds) Medicinal Mushrooms. Springer, Singapore. https://doi.org/10.1007/978-981-13-6382-5_10
Download citation
DOI: https://doi.org/10.1007/978-981-13-6382-5_10
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-6381-8
Online ISBN: 978-981-13-6382-5
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)