Abstract
Drug delivery is defined as administration of drug component inside the body, and the system adopted for the same is known as drug delivery system. Advancements in the drug delivery system are gaining more attention and popularity due to the use of nanoformulations that enables efficient, effective and specific targeting of the drug. Several drug carriers such as liposomes, aptamers, quantum dots, peptide, polymers, metals and magnetic nanoparticle-based delivery are categorised as advanced generation drug delivery systems. The structural complexity of nano-based drug delivery system, e.g. nanocapsules, dendrimers, nanosponges, nanocrystals, nanogels and nanocapsules, provides high surface area for precise targeting in the field of cancer management and several other life-threatening diseases.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Alley SC, Okeley NM, Senter PD (2010) Antibody-drug conjugates: targeted drug delivery for cancer. Curr Opin Chem Biol 14:529–537
Amstad E et al (2009) Surface functionalization of single superparamagnetic iron oxide nanoparticles for targeted magnetic resonance imaging. Small Weinh Bergstr Ger 5:1334–1342
Bagalkot V, Farokhzad OC, Langer R, Jon S (2006) An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform. Angew Chem Int Ed Eng 45:8149–8152
Bamrungsap S et al (2012) Nanotechnology in therapeutics: a focus on nanoparticles as a drug delivery system. Nanomedicine 7:1253–1271
Bates PJ, Choi EW, Nayak LV (2009) G-rich oligonucleotides for cancer treatment. Methods Mol Biol Clifton NJ 542:379–392
Bhat M, Shenoy SD, Udupa N, Srinivas CR (1995) Optimization of delivery of betamethasone-dipropionate from skin preparation. Indian Drugs 32:211–214
BrentuximabVedotin (ADCETRIS®) Seattle genetics. Available at: http://www.seattlegenetics.com/pipeline/brentuximab-vedotin
Çağdaş M, Sezer AD, Bucak S (2014) Liposomes as potential drug carrier systems for drug delivery. Appl Nanotechnol Drug Deliv. https://doi.org/10.5772/58459
Catuogno S, Esposito CL, de Franciscis V (2016) Aptamer-mediated targeted delivery of therapeutics: an update. Pharm Basel Switz 9:69
Chan WCW, Nie S (1998) Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 281:2016–2018
Charoenphol P, Bermudez H (2014) Aptamer-targeted DNA nanostructures for therapeutic delivery. Mol Pharm 11:1721–1725
Chertok B et al (2008) Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors. Biomaterials 29:487–496
Cortesi R, Esposito E, Luca G, Nastruzzi C (2002) Production of lipospheres as carriers for bioactive compounds. Biomaterials 23:2283–2294
Cui B et al (2007) One at a time, live tracking of NGF axonal transport using quantum dots. Proc Natl Acad Sci U S A 104:13666–13671
De Jong WH, Borm PJ (2008) Drug delivery and nanoparticles: applications and hazards. Int J Nanomedicine 3(2):133
Delehanty JB et al 2006 Self-assembled quantum dot-peptide bioconjugates for selective intracellular delivery. PubMed – NCBI. Available at: https://www.ncbi.nlm.nih.gov/pubmed/16848398. Accessed: 5th Jan 2019
Delehanty JB, Mattoussi H, Medintz IL (2009) Delivering quantum dots into cells: strategies, progress and remaining issues. Anal Bioanal Chem 393:1091–1105
Ding M et al (2013) Toward the next-generation nanomedicines: design of multifunctional multiblock polyurethanes for effective cancer treatment. ACS Nano 7:1918–1928
Ducry L, Stump B (2010) Antibody-drug conjugates: linking cytotoxic payloads to monoclonal antibodies. Bioconjug Chem 21:5–13
Dunn GP et al (2012) Emerging insights into the molecular and cellular basis of glioblastoma. Genes Dev 26:756–784
Elbaz NM, Khalil IA, Abd-Rabou AA, El-Sherbiny IM (2016) Chitosan-based nano-in-microparticle carriers for enhanced oral delivery and anticancer activity of propolis. Int J Biol Macromol 92:254–269
Ellington AD, Szostak JW (1990) In vitro selection of RNA molecules that bind specific ligands. Nature 346:818–822
Fakhoury JJ, McLaughlin CK, Edwardson TW, Conway JW, Sleiman HF (2014) Development and characterization of gene silencing DNA cages. Biomacromolecules 15:276–282
Fayad L et al (2008) Safety and clinical activity of the anti-CD22 Immunoconjugate InotuzumabOzogamicin (CMC-544) in combination with rituximab in follicular lymphoma or diffuse large B-cell lymphoma: preliminary report of a phase 1/2 study. Blood 112:266–266
Feng M, Zhong LX, Zhan ZY, Huang ZH, Xiong JP (2017) Enhanced antitumor efficacy of resveratrol-loaded nanocapsules in colon cancer cells: physicochemical and biological characterization. Eur Rev Med Pharmacol Sci 21(2):375–382
Gattenlöhner S et al (2010) A human recombinant autoantibody-based immunotoxin specific for the fetal acetylcholine receptor inhibits rhabdomyosarcoma growth in vitro and in a murine transplantation model. J Biomed Biotechnol 2010:187621–187621
Goldenberg DM (2007) Radiolabelled monoclonal antibodies in the treatment of metastatic cancer. Curr Oncol 14:39–42
Gu F et al (2008) Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers. Proc Natl Acad Sci U S A 105:2586–2591
He J et al (2010) Targeting prostate cancer cells in vivo using a rapidly internalizing novel human single-chain antibody fragment. J Nucl Med Off Publ Soc Nucl Med 51:427–432
He K et al (2017) The efficacy assessments of alkylating drugs induced by nano-Fe3O4/CA for curing breast and hepatic cancer. Spectrochim Acta A Mol Biomol Spectrosc 173:82–86
Heitner T et al (2001) Selection of cell binding and internalizing epidermal growth factor receptor antibodies from a phage display library. J Immunol Methods 248:17–30
Hu R et al (2014) DNA nanoflowers for multiplexed cellular imaging and traceable targeted drug delivery. Angew Chem Int Ed Eng 53:5821–5826
Hua X-W, Bao Y-W, Wu F-G (2018) Fluorescent carbon quantum dots with intrinsic nucleolus-targeting capability for nucleolus imaging and enhanced cytosolic and nuclear drug delivery. ACS Appl Mater Interfaces 10:10664–10677
Jabbari A, Sadeghian H (2012) Amphiphilic cyclodextrins, synthesis, utilities and application of molecular modeling in their design. Recent Adv Nov Drug Carr Syst. https://doi.org/10.5772/50220
Jain KK (ed) (2008) Drug delivery systems, vol 2. Humana press, Totowa
Jensen SA et al (2013) Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma. Sci Transl Med 5:209ra152
Jiang Q et al (2012) DNA origami as a carrier for circumvention of drug resistance. J Am Chem Soc 134:13396–13403
Johnson BK, Prud’homme RK (2003) Flash nanoprecipitation of organic actives and block copolymers using a confined impinging jets mixer. Aust J Chem 56:1021–1024
Kamaly N, Xiao Z, Valencia PM, Radovic-Moreno AF, Farokhzad OC (2012) Targeted polymeric therapeutic nanoparticles: design, development and clinical translation. Chem Soc Rev 41:2971–3010
Kang WJ, Chae JR, Cho YL, Lee JD, Kim S (2009) Multiplex imaging of single tumor cells using quantum-dot-conjugated aptamers. Small Weinh Bergstr Ger 5:2519–2522
Kang T et al (2017) Surface design of magnetic nanoparticles for stimuli-responsive cancer imaging and therapy. Biomaterials 136:98–114
Keefe AD, Pai S, Ellington A (2010) Aptamers as therapeutics. Nat Rev Drug Discov 9:537–550
Kikkeri R, Lepenies B, Adibekian A, Laurino P, Seeberger PH (2009) In vitro imaging and in vivo liver targeting with carbohydrate capped quantum dots. J Am Chem Soc 131:2110–2112
Kim J-E, Park Y-J (2017) Paclitaxel-loaded hyaluronan solid nanoemulsions for enhanced treatment efficacy in ovarian cancer. Int J Nanomedicine 12:645. https://doi.org/10.2147/IJN.S124158
Klostergaard J et al (2007) Magnetic vectoring of magnetically responsive nanoparticles within the murine peritoneum. J Magn Magn Mater 311:330–335
Klostergaard J, Bankson J, Woodward W, Gibson D, Seeney C (2010) Magnetically-responsive nanoparticles for vectored delivery of cancer therapeutics. AIP Conf Proc 1311:382–387
Klostranec JM, Chan WCW (2006) Quantum dots in biological and biomedical research: recent progress and present challenges. Adv Mater 18:1953–1964
Kotula JW et al (2012) Aptamer-mediated delivery of splice-switching oligonucleotides to the nuclei of cancer cells. Nucleic Acid Ther 22:187–195
Kumar CSSR, Mohammad F (2011) Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery. Adv Drug Deliv Rev 63:789–808
Lavik EB, Kuppermann BD, Humayun MS (2012) Drug delivery. In: Retina, 5th edn. Allen Institute for Artificial Intelligence, Seattle, pp 734–745. https://doi.org/10.1016/B978-1-4557-0737-9.00038-2
Lee N, Hyeon T (2012) Designed synthesis of uniformly sized iron oxide nanoparticles for efficient magnetic resonance imaging contrast agents. Chem Soc Rev 41:2575–2589
Lee H et al (2012) Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery. Nat Nanotechnol 7:389–393
Levy-Nissenbaum E, Radovic-Moreno AF, Wang AZ, Langer R, Farokhzad OC (2008) Nanotechnology and aptamers: applications in drug delivery. Trends Biotechnol 26:442–449
Lherm C, Müller RH, Puisieux F, Couvreur P (1992) Alkylcyanoacrylate drug carriers: II. Cytotoxicity of cyanoacrylate nanoparticles with different alkyl chain length. Int J Pharm 84:13–22
Liao W et al (2018) Fabrication of ultra-small WS2 quantum dots-coated periodic mesoporous organosilica nanoparticles for intracellular drug delivery and synergistic chemo-photothermal therapy. OncoTargetsTher 11:1949–1960
Lidke DS et al (2004) Quantum dot ligands provide new insights into erbB/HER receptor-mediated signal transduction. Nat Biotechnol 22:198–203
Lieleg O et al (2007) Specific integrin labeling in living cells using functionalized nanocrystals. Small Weinh Bergstr Ger 3:1560–1565
Liu W et al (2008) Compact biocompatible quantum dots functionalized for cellular imaging. J Am Chem Soc 130:1274–1284
Lundin J et al (2002) Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL). Blood 100:768–773
Medintz IL et al 2005 Quantum dot bioconjugates for imaging, labelling and sensing. PubMed – NCBI. Available at: https://www.ncbi.nlm.nih.gov/pubmed/15928695. Accessed: 5th Jan 2019
Mok H, Zhang M (2013) Superparamagnetic iron oxide nanoparticle-based delivery systems for biotherapeutics. Expert Opin Drug Deliv 10:73–87
Nahar S, Nayak AK, Ghosh A, Subudhi U, Maiti S (2017) Enhanced and synergistic downregulation of oncogenic miRNAs by self-assembled branched DNA. Nanoscale 10:195–202
Nielsen UB et al (2002) Therapeutic efficacy of anti-ErbB2 immunoliposomes targeted by a phage antibody selected for cellular endocytosis. Biochim Biophys Acta 1591:109–118
Oh JK, Park JM (2011) Iron oxide-based superparamagnetic polymeric nanomaterials: design, preparation, and biomedical application. Prog Polym Sci 36:168–189
Öztürk K, Esendağlı G, Gürbüz MU, Tülü M, Çalış S (2017) Effective targeting of gemcitabine to pancreatic cancer through PEG-cored Flt-1 antibody-conjugated dendrimers. Int J Pharm 517:157–167
Park K (2014) Controlled drug delivery systems: past forward and future back. J Control Release Off 190:3–8
Pathak Y, Benita S (2012a) Antibody-mediated drug delivery systems: concepts, technology, and applications. Wiley, Hoboken
Pathak Y, Benita S (2012b) Antibody-mediated drug delivery systems: concepts, technology, and applications. Wiley, Hoboken
Patri AK, Majoros IJ, Baker JR (2002) Dendritic polymer macromolecular carriers for drug delivery. Curr Opin Chem Biol 6:466–471
Prasad M et al (2018) Nanotherapeutics: an insight into healthcare and multi-dimensional applications in medical sector of the modern world. Biomed Pharmacother 97:1521–1537
Qian H et al (2017) Protecting microRNAs from RNase degradation with steric DNA nanostructures. Chem Sci 8:1062–1067
Qiao R, Yang C, Gao M (2009) Superparamagnetic iron oxide nanoparticles: from preparations to in vivo MRI applications. J Mater Chem 19:6274–6293
Ramakrishna D, Rao P (2011) Nanoparticles: is toxicity a concern? EJIFCC 22:92–101
Rao PR, Diwan PV (1997) Permeability studies of cellulose acetate free films for transdermal use: influence of plasticizers. Pharm ActaHelv 72:47–51
Singh R, Lillard JW (2009) Nanoparticle-based targeted drug delivery. Exp Mol Pathol 86:215–223
Smith BR et al (2008) Real-time intravital imaging of RGD-quantum dot binding to luminal endothelium in mouse tumor neovasculature. Nano Lett 8:2599–2606
Soundararajan S, Chen W, Spicer EK, Courtenay-Luck N, Fernandes DJ (2008) The nucleolin targeting aptamer AS1411 destabilizes Bcl-2 messenger RNA in human breast cancer cells. Cancer Res 68:2358–2365
Stacker SA, Achen MG, Jussila L, Baldwin ME, Alitalo K (2002) Lymphangiogenesis and cancer metastasis. Nat Rev Cancer 2:573–583
Sun C, Lee JSH, Zhang M (2008) Magnetic nanoparticles in MR imaging and drug delivery. Adv Drug Deliv Rev 60:1252–1265
Sun W et al (2015) Self-assembled DNA nanoclews for the efficient delivery of CRISPR-Cas9 for genome editing. Angew Chem Int Ed Eng 54:12029–12033
Susumu K et al (2007) Enhancing the stability and biological functionalities of quantum dots via compact multifunctional ligands. J Am Chem Soc 129:13987–13996
Tuerk C, Gold L (1990) Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 249:505–510
Turturro F (2007) Denileukindiftitox: a biotherapeutic paradigm shift in the treatment of lymphoid-derived disorders. Expert Rev Anticancer Ther 7:11–17
Varkouhi AK, Scholte M, Storm G, Haisma HJ (2011) Endosomal escape pathways for delivery of biologicals. J Control Release Off 151:220–228
Veiseh O, Gunn JW, Zhang M (2010) Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging. Adv Drug Deliv Rev 62:284–304
Wang AZ et al (2010) ChemoRad nanoparticles: a novel multifunctional nanoparticle platform for targeted delivery of concurrent chemoradiation. Nanomedicine (London) 5:361. https://doi.org/10.2217/nnm.10.6
Wanigasekara J, Witharana C (2016) Applications of nanotechnology in drug delivery and design-an insight. Curr Trends Biotechnol Pharm 10(1):78–91
Wen PY, Kesari S (2008) Malignant gliomas in adults. N Engl J Med 359:492–507
Wen J, Tao W, Hao S, Iyer SP, Zu Y (2016) A unique aptamer-drug conjugate for targeted therapy of multiple myeloma. Leukemia 30:987–991
Werner ME et al (2011) Folate-targeted nanoparticle delivery of chemo- and radiotherapeutics for the treatment of ovarian cancer peritoneal metastasis. Biomaterials 32:8548–8554
Wilczewska AZ, Niemirowicz K, Markiewicz KH, Car H (2012) Nanoparticles as drug delivery systems. Pharmacol Rep PR 64:1020–1037
Wu C et al (2013) Building a multifunctional aptamer-based DNA nanoassembly for targeted cancer therapy. J Am Chem Soc 135:18644–18650
Wu W, Wu Z, Yu T, Jiang C, Kim W-S (2015) Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications. Sci Technol Adv Mater 16:023501
Yang D et al (2016a) In vivo targeting of metastatic breast cancer via tumor vasculature-specific nano-graphene oxide. Biomaterials 104:361–371
Yang Y et al (2016b) Near-infrared light-activated cancer cell targeting and drug delivery with aptamer-modified nanostructures. Nano Res 9:139–148
Younes A et al (2008) Objective responses in a phase I dose-escalation study of SGN-35, a novel antibody-drug conjugate (ADC) targeting CD30, in patients with relapsed or refractory Hodgkin lymphoma. J Clin Oncol 26:8526–8526
Yun YH, Lee BK, Park K (2015) Controlled drug delivery: historical perspective for the next generation. J Control Release 219:2–7
Zaman MB, Baral TN, Zhang J, Whitfield D, Yu K (2009) Single-domain antibody functionalized CdSe/ZnS quantum dots for cellular imaging of cancer cells. J Phys Chem C 113:496–499
Zhang H et al (2009) Detection and downregulation of type I IGF receptor expression by antibody-conjugated quantum dots in breast cancer cells. Breast Cancer Res Treat 114:277–285
Zhang Q et al (2014) DNA origami as an in vivo drug delivery vehicle for cancer therapy. ACS Nano 8:6633–6643
Zhang H et al (2015) A controllable aptamer-based self-assembled DNA dendrimer for high affinity targeting, bioimaging and drug delivery. Sci Rep 5:10099
Zhao Y-X et al (2012) DNA origami delivery system for cancer therapy with tunable release properties. ACS Nano 6:8684–8691
Zheng J et al (2006) Cellular imaging and surface marker labeling of hematopoietic cells using quantum dot bioconjugates. Lab Hematol Off Publ Int Soc Lab Hematol 12:94–98
Acknowledgement
This work was financially supported by a DST-INSPIRE (DST/INSPIRE/04/2013/000836) research grant from the Department of Science and Technology, Government of India. The authors would also like to thank the Institute Research Project (IRP) scheme for individual faculty provided by the Indian Institute of Technology (Banaras Hindu University) for the development of state-of-the-art facilities.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Sahi, A.K., Verma, P., Pallawi, Singh, K., Mahto, S.K. (2019). Advancements and New Technologies in Drug Delivery System. In: Paul, S. (eds) Biomedical Engineering and its Applications in Healthcare. Springer, Singapore. https://doi.org/10.1007/978-981-13-3705-5_28
Download citation
DOI: https://doi.org/10.1007/978-981-13-3705-5_28
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-3704-8
Online ISBN: 978-981-13-3705-5
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)