Abstract
At micro-architectural viewpoint, human bone is composed of polymer ceramic composite having similar mechanical characteristics that can be tailored by synthetic composite materials. To mimic the properties of bone, research on bone substituted analogous biomaterials was initiated by reinforcing active biomolecules within the matrices of biocompatible polymers to formulate suitable bone analogous. The major advantages of the composites over conventional homogeneous materials like metals, ceramics, and polymers are superior mechanical, biological, and other physical properties that can be matched with the requirements of particular applications. Modern technology has not been able to provide a suitable bone substitute that replaces autogenous bone. The availability and suitability of conventional autogenous or homogeneous prosthetic elements to repair severe bone trauma or large defects caused by various bone diseases are critically limited; as a result, profound interest concentrated on application of man-made polymeric composite materials as biodegradable scaffold, which would provide support and a symptomatic, long-term function within the body or in contact with body fluid. In tissue engineering, biodegradable scaffolds play a crucial role, where matrix degradation and tissue in growth are of immense phenomenon for decisive performance of tissue-scaffold system during regenerative process.
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Akbarzadeh R, Yousefi AM (2014) Effects of processing parameters in thermally induced phase separation technique on porous architecture of scaffolds for bone tissue engineering. J Biomed Mater Res B Appl Biomater 102(6):1304–1315
Ambrose CG, Hartline BE, Clanton TO, Lowe WR, McGarvey WC (2015) Polymers in orthopaedic surgery. In: Advanced polymers in medicine. Springer, Berlin/Heidelberg, pp 129–145
Ami R, Amini, Laurencin CT, Nukavarapu SP (2012) Bone tissue engineering: recent advances and challenges. Crit Rev Biomed Eng 40(5):363–408
Amin Y, Wauthle R, Böttger AJ, Schrooten J, Weinans H, Zadpoor AA (2014) Crystal structure and nanotopographical features on the surface of heat-treated and anodized porous titanium biomaterials produced using selective laser melting. Appl Surf Sci 290:287–294
Annalia A, Luciana G (2014) Natural and synthetic biodegradable polymers: different scaffolds for cell expansion and tissue formation. Int J Artif Organs 37(3):187–205
Asti A, Gioglio L (2014) Natural and synthetic biodegradable polymers: different scaffolds for cell expansion and tissue formation. Int J Artif Organs 37(3):187–205
Balani K, Narayan R, Agarwal A (2015) Surface engineering and modification for biomedical applications. In Balani K, Verma V, Agaqrwal A, Narayan R (Eds) Biosurfaces: materials science and engineering perspective, John Wiley, pp 201–238
BaoLin G, Ma PX (2014) Synthetic biodegradable functional polymers for tissue engineering: a brief review. Sci China Chem 57(4):490–500
Basile MA, d’Ayala GG, Malinconico M, Laurienzo P, Coudane J, Nottelet B, Ragione FD, Oliva A (2015) Functionalized PCL/HA nanocomposites as microporous membranes for bone regeneration. Mater Sci Eng C Mater Biol Appl 48:457–468
Bastioli C (2005) Handbook of biodegradable polymers. Rapra Technology, Shawbury/Shrewsbury/Shropshire. ISBN 9781847350442
Bertazzo S, Bertran CA (2006) Morphological and dimensional characteristics of bone mineral crystals. Bioceramics 3(10):309–311
Bhattacharjee A, Bansal M (2005) Critical review collagen structure: the madras triple helix and the current scenario. IUBMB Life 57:161–172
Bitar KN, Zakhem E (2014) Design strategies of biodegradable scaffolds for tissue regeneration. Biomed Eng Comput Biol 6:13–20
Blokhuis TJ (2014) Bioresorbable bone graft substitutes. In: Bone substitute biomaterials, pp 80–92, Elsevier
Borden M, Attawia M, Khan Y, El-Amin SF, Laurencin CT (2004) Tissue-engineered bone formation in vivo using a novel sintered polymeric microsphere matrix. J Bone Joint Surg Br 86:1200–1208
Boschetti F, Tomei AA, Turri S, Swartz MA, Levi M (2008) Design, fabrication, and characterization of a composite scaffold for bone tissue engineering. Int J Artif Organs 31(8):697–707
Bret DU, Lakshmi SN, Cato TL (2011) Biomedical applications of biodegradable polymers. Biomedical applications of biodegradable polymers. J Polym Sci B Polym Phys 49(12):832–864
Brodsky B, Persikov AV (2005) Molecular structure of thecollagen triple helix. Adv Protein Chem 70:301–339
Buehler MJ (2006) Nature designs tough collagen: explaining the nanostructure of collagen fibrils. PNAS 103(33):12285–12290
Cardiel JJ, Zhao Y, Kim J-H, Chung J-H, Shen AQ, Shen AQ (2014) Electro-conductive porous scaffold with single-walled carbon nanotubes in wormlike micellar networks. Carbon 80:203–212
Chan BP, Leong KW (2008) Scaffolding in tissue engineering: general approaches and tissue-specific considerations. Eur Spine J 17(S4):467–479
Chandra R, Rustgi R (1998) Biodegradable polymers. Prog Polym Sci 23:1273–1335
Chanlalit C, Shukla DR, Fitzsimmons JS, An KN, O’Driscoll SW (2012) Stress shielding around radial head prostheses. J Hand Surg 37:2118–2125
Chun-Jen L, Chin-Fu C, Jui-Hsiang C, Shu-Fung C, Yu-Ju L, Ken-Yuan C (2002) Fabrication of porous biodegradable polymer scaffolds using a solvent merging/particulate leaching method. J Biomed Mater Res Part A 59(4):676–681
Cox SC, Thornby JA, Gibbons GJ, Williams MA, Mallick KK (2015) 3D printing of porous hydroxyapatite scaffolds intended for use in bone tissue engineering applications. Mater Sci Eng C 47:237–247
Cunniffe G, O’Brien F (2011) Collagen scaffolds for orthopedic regenerative medicine. J Miner Met Mater Soc 63(4):66–73
Currey JD (2002) The structure of bone tissue. In: Bones: structure and mechanics. Princeton University Press, Princeton, pp 12–14
Dahlin RL, Kasper FK, Mikos AG (2011) Polymeric nanofibers in tissue engineering. Tissue Eng B Rev 17:349–364
De Santis R, Gloria A, Russo T, Amora UD, Zeppetelli S, Tampieri A, Herrmannsdorfer T, Ambrosio L (2011) A route toward the development of 3D magnetic scaffolds with tailored mechanical and morphological properties for hard tissue regeneration: preliminary study. Virtual Phys Prototyping 6(4):189–195
Dinopoulos H, Dimitriou R, Giannoudis PV (2012) Bone graft substitutes: what are the options? Surgeon 10(4):230–239
Dumic-Cule I, Pecina M, Jelic M, Jankolija M, Popek I, Grgurevic L, Vukicevic S (2015) Biological aspects of segmental bone defects management. Int Orthop 39:1005–1011
Edwards SL, Werkmeister JA, Ramshaw JA (2009) Carbon nanotubes in scaffolds for tissue engineering. Expert Rev Med Devices 6(5):499–505
Fabrizio M, Lorenzo N, DianaChicon P, Massimo I (2011) New biomaterials for bone regeneration. Clin Cases Miner Bone Metab 8(1):21–24
Francesca G, Alessandro S, Giuseppe MP (2013) The biomaterialist’s task: scaffold biomaterials and fabrication technologies. Joints 1(3):130–137
Fu Q, Saiz E, Rahaman MN, Tomsia AP (2011) Bioactive glass scaffolds for bone tissue engineering: state of the art and future perspectives. Mater Sci Eng C Mater Biol 31(7):1245–1256
Galois L, Mainard D, Delagoutte J (2002) Beta-tricalcium phosphate ceramic as a bone substitute in orthopaedic surgery. Int Orthop 26:109–115
Gloria A, Russo T, D’Amora U, Zeppetelli S, D’Alessandro T, Sandri M, Bañobre-López M, Piñeiro-Redondo Y, Uhlarz M, Tampieri A, Rivas J, Herrmannsdörfer T, Dediu VA, Ambrosio L, DeSantis R (2013) Magnetic poly(ε-caprolactone)/iron-doped hydroxyapatite nanocomposite substrates for advanced bone tissue engineering. J R Soc Interface 10(80):8–33
Goldberg M, Kulkarni AB, Young M, Boskey A (2011) Dentin: structure, composition and mineralization-the role of dentin ECM in dentin formation and mineralization. Front Biosci (Elite Ed) 3:711–735
Gunatillake PA, Adhikari R (2003) Biodegradable synthetic polymers for tissue engineering. Eur Cell Mater 5:1–16
Haase K, Rouhi G (2013) Prediction of stress shielding around an orthopedic screw. Using stress and strain energy density as mechanical stimuli. Comput Biol Med 43:1748–1757
Haigang GU, Zhilian Y, Bramasta N, Leong WS, Tan JP (2010) Control of invitro neural differentiation of mesenchymal stem cells in 3D macroporous, cellulosic hydrogels. Regen Med 5:245–253
Hench LL (2013) Chronology of bioactive glass development and clinical applications. Sci Res 3:67–73
Huayu Tian, Zhaohui Tang, Xiuli Zhuang, Xuesi Chen, Xiabin Jing (2012) Biodegradable synthetic polymers: preparation, functionalization and biomedical application. Prog Polym Sci 37(2):237–280
Hutmacher DW (2000) Scaffolds in tissue engineering bone and cartilage. Biomaterials 21(24):2529–2543
Iftikhar A, Nazia J (2016) Polyhydroxyalkanoates: current applications in the medical field. Front Biol 11(1):19–27
Ikada Y (2006) Challenges in tissue engineering. J R Soc Interface 3:589–601
Jack KS, Velayudhan S, Luckman P, Trau M, Grøndahl L, Cooper-White J (2009) The fabrication and characterization of biodegradable HA/PHBV nanoparticle-polymer composite scaffolds. Acta Biomater 5(7):2657–2667
Khan R, Khan MH (2013) Use of collagen as a biomaterial: an update. J Indian Soc Periodontol 17(4):539–542
Krishnan V, Lakshmi T (2013) Bioglass: a novel biocompatible innovation. J Adv Pharm Technol Res 4(2):78–83
Lalwani G, Gopalan A, D’Agati M, Sankaran JS, Judex S, Qin YX, Sitharaman B (2015) Porous three-dimensional carbon nanotube scaffolds for tissue engineering. J Biomed Mater Res 103(10):3212–3225
Laurin M, Canoville A, Germain D (2011) Bone microanatomy and lifestyle: a descriptive approach. Comptes Rendus Palevol 10(5–6):381–402
Lee DW et al (2006) Strong adhesion and cohesion of chitosan in aqueous solutions. Langmuir 29(46):14222–14229
Lee JW, Kim JY, Kim JY, Cho D-W, Cho D-W (2010a) Solid free-form fabrication technology and its application to bone tissue engineering. Int J Stem Cells 3(2):85–95
Lee K-W, Wang S, Dadsetan M, Yaszemski MJ, Lu L (2010b) Enhanced cell ingrowth and proliferation through three-dimensional nanocomposite scaffolds with controlled pore structures. Biomacromolecules 11(3):682–689
Lendlein A, Sisson A (eds) (2011) Handbook of biodegradable polymers : synthesis, characterization and applications. Weinheim, Wiley-VCH
Levrero F, Margetts L et al (2016) Evaluating the macroscopic yield behaviour of trabecular bone using a nonlinear homogenisation approach. J Mech Behav Biomed Mater 61:384–396
Li X, Cui R, Sun L, Aifantis KE, Fan Y, Feng Q, Cui F, Watari F (2014) 3D-printed biopolymers for tissue engineering application. Int J Polym Sci 2014:1–13
Lim LT, Auras R, Rubino M (2008) Processing technologies for poly (lactic acid). Prog Polym Sci 33(8):820–852
Liu B, Lun DX (2012) Current application of β-tricalcium phosphate composites in orthopaedics. Orthop Surg 4:139–144
Ma PX (2004) Scaffolds for tissue fabrication. Mater Today 7(5):30–40
Makadia HK, Siegel SJ (2011) Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier. Polymers (Basel) 3(3):1377–1397
Maria Fátima Vaz, Helena CanhÐo, JoÐo Eurico Fonseca (2011) Bone: a composite natural material. In: Pavla (ed) Advances in composite materials – analysis of natural and man-made materials. Intech, Croatia
Masina M (2011) Use of an absorbent non-woven fabric dressing based on benzyl ester of hyaluronic acid (Hyallofill®-F) in the treatment of difficult to heal ulcers of the lower extremities. Acta Vulcanol 9(4):173–181
Massera J, Fagerlund S, Hupa L, Hupa M (2012) Crystallization mechanism of bioactive glasses 45S5 and S53P4. J Am Ceram Soc 95(2):607–613
Middleton J, Tipton A (1998) Synthetic biodegradable polymers as medical devices. Med Plast Biomater Mag 5(2):30–39
Mikael PE, Nukavarapu SP (2011) Functionalized carbon nanotube composite scaffolds for bone tissue engineering: prospects and progress. J Biomater Tissue Eng 1(1):76–85
Miranda P, Saiz E, Gryn K, Tomsia AP (2006) Sintering and robocasting of β-tricalcium phosphate scaffolds for orthopaedic applications. Acta Biomater 2:457–466
Mirza SB, Dunlop DG, Panesar SS, Naqvi SG, Gangoo S, Salih S (2010) Basic science considerations in primary total hip replacement arthroplasty. Open Orthop J 4:169–180
Niu XF, Li XM, Liu HF (2012) Homogeneous chitosan/poly(L-lactide) composite scaffolds prepared by emulsion freeze-drying. J Biomater Sci Polym Ed 23:391–404
Oh Y, Islam MF (2015) Preformed Nanoporous carbon nanotube scaffold-based multifunctional polymer composites. ACS Nano 9(4):4103–4110
Oonishi H (1991) Orthopaedic applications of hydroxyapatite. Biomaterials 12(2):171–178
Osborn JF, Newesely H (1980) The material science of calcium phosphate ceramics. Biomaterials 1(2):108–111
Peck M, Dusserre N, McAllister TN, L’Heureux N (2011) Tissue engineering by self- assembly. Mater Today 14:218–224
PeitlFilho O, LaTorre GP, Hench LL (1996) Effect of crystallization on apatite-layer formation of bioactive glass 45S5. J Biomed Mater Res 30(4):509–514
Persson M, Lorite GS, Kokkonen HE, Cho SW, Lehenkari PP, Skrifvars M, Tuukkanen J (2014) Effect of bioactive extruded PLA/HA composite films on focal adhesion formation of preosteoblastic cells. Colloids Surf B Biointerfaces 121:409–416
Polo-Corrales L, Latorre-Esteves M, Ramirez-Vick JE (2014) Scaffold design for bone regeneration. J Nanosci Nanotechnol 14(1):15–56
Prakasam M, Locs J, Salma-Ancane K, Loca D, Largeteau A, Berzina-Cimdina L (2015) Fabrication, properties and applications of dense hydroxyapatite: a review. J Funct Biomater 6(4):1099–1140
Raeisdasteh Hokmabad V, Davaran S, Ramazani A, Salehi R (2017) Design and fabrication of porous biodegradable scaffolds: a strategy for tissue engineering. J Biomater Sci Polym Ed 28(16):1797–1825
Rahaman MN, Day DE, Bal BS, Fu Q, Jung SB (2011) Bioactive glass in tissue engineering. Acta Biomater 7(6):2355–2373
Rahaman MN, Liu X, Bal BS, Day DE, Bi L, Bonewald LF (2012) Bioactive glass in bone tissue engineering. Biomater Sci 237:73–82
Ratner BD (2004) Biomaterials science: an introduction to materials in medicine. Academic Press, Waltham
Raynaud S, Champion E, Bernache-Assollant D, Thomas P (2002) Calcium phosphate apatites with variable Ca/P atomic ratio I. Synthesis, characterisation and thermal stability of powders. Biomaterials 23(4):1065–1072
Razak SIA, Sharif N, Rahman W (2012) Biodegradable polymers and their bone applications: a review. Int J Basic Appl Sci 12:31–49
Rezwan K, Chen QZ, Blaker JJ, Boccaccini AR (2006) Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials 27(18):3413–3431
Sahoo NG, Pan YZ, Li L, He CB (2013) Nanocomposites for bone tissue regeneration. Nanomedicine 8(4):639–653
Samavedi S, Whittington AR, Goldstein AS (2013) Calcium phosphate ceramics in bone tissue engineering: a review of properties and their influence on cell behavior. Acta Biomater 9(9):8037–8045
Saska S, Mendes LS, Gaspar AMM, de Oliveira Capote TS (2015) Bone substitute materials in implant dentistry. Implant Dent 2:158–167
Schaschke C, Audic JL (Editorial) (2014) Biodegradable materials. Int J Mol Sci 15:21468–21475
Si-Chong Chen, Zhi-Xuan Zhou, Yu-Zhong Wang, Xiu-Li Wang, Ke-Ke Yang (2006) A novel biodegradable poly(p-dioxanone)-grafted poly(vinyl alcohol) copolymer with a controllable in vitro degradation. Polymer 47(1):32–36
Simamora P, Chern W (2006) Poly-L-lactic acid: an overview. J Drugs Dermatol 5(5):436–440
Singh AB, Majumdar S (2014) The composite of hydroxyapatite with collagen as a bone grafting material. J Adv Med Dent Sci Res 2:53–55
Singh M, Sandhu B, Scurto A, Berkland C, Detamore MS (2010) Microsphere-based scaffolds for cartilage tissue engineering: using subcritical CO(2) as a sintering agent. Acta Biomater 6(1):137–143
Sokolsky PM, Agashi K, Olaye A, Shakesheff K, Domb AJ (2007) Polymer carriers for drug delivery in tissue engineering. Adv Drug Deliv Rev 59:187–206
Sumner DR (2015) Long-term implant fixation and stress-shielding in total hip replacement. J Biomech 48:797–800
Tamimi F, Sheikh Z, Barralet J (2012) Dicalcium phosphate cements: Brushite and monetite. Acta Biomater 8:474–487
Tan L, Yu X, Wan P, Yang K (2013) Biodegradable materials for bone repairs: a review. J Mater Sci Technol 29:503–513
Tian H, Tang Z, Zhuang X, Chen X, Jing X (2012) Biodegradable synthetic polymers: preparation, functionalization and biomedical application. Prog Polym Sci 37(2):237–280
Udeni Gunathilake TMS, Ching YC, Chuah CH, Sabariah JJ, Pai-Chen L (2016) Fabrication of porous materials from natural/synthetic biopolymers and their composites. Materials 9(12):991
Ulrike G, Wegst K, Bai H, Eduardo S, Antoni PT, Ritchie RO (2015) Bioinspired structural materials. Nat Mater 14:23–36
Valappil SP, Misra SK, Boccaccini AR, Roy I (2006) Biomedical applications of polyhydroxyalkanoates: an overview of animal testing and in vivo responses. Expert Rev Med Devices 3(6):853–868
Vallittu PK, Närhi TO, Hupa L (2015) Fiber glass–bioactive glass composite for bone replacing and bone anchoring implants. Dent Mater 31:371–381
Vindigni V, Cortivo R, Iacobellis L, Abatangelo G, Zavan B (2009) Hyaluronan benzyl ester as a scaffold for tissue engineering. Int J Mol Sci 10(7):2972–2985
Wang Y, Jiang XL, Peng SW, Guo XY, Shang GG, Chen JC, Wu Q, Chen GQ (2013) Induced apoptosis of osteoblasts proliferating on polyhydroxyalkanoates. Biomaterials 34(15):3737–3746
Wu Q, Wang Y, Chen GQ (2009) Medical application of microbial biopolyesters polyhydroxyalkanoates artificial cells. Blood Substitutes Biotechnol 37(1):1–12
Xiao L, Wang B, Yang G, Gauthier M (2012) Poly (lactic acid)-based biomaterials: synthesis, modification and applications. In: Biomedical science, engineering and technology, pp 247–282. InTech, Croatia
Yamamuro T (2012) Clinical applications of bioactive glass-ceramics. New Mater Technol Healthc 1:1–97
Zanello LP, Zhao B, Hu H, Haddon RC (2006) Bone cell proliferation on carbon nanotubes. Nano Lett 6(3):562–567
Zeeshan S, Shariq N, Zohaib K, Vivek V, Haroon R, Michael G (2015) Biodegradable materials for bone repair and tissue engineering applications. Materials (Basel) 8(9):5744–5794
Zhao J, Han W, Chen H (2011) Preparation, structure and crystallinity of chitosan nano-fibers by a solid-liquid phase separation technique. Carbohydr Polym 83:1541–1546
Zhao Q, Wang S, Kong M, Geng W, Li RK, Song C, Kong D (2012) Phase morphology, physical properties, and biodegradation behavior of novel PLA/PHBHHx blends. J Biomed Mater Res B Appl Biomater 100(1):23–31
Zhu S, Sun H, Geng H, Liu D, Zhang X, Cai Q, Yang X (2016a) Dual functional polylactide–hydroxyapatite nanocomposites for bone regeneration with nano-silver being loaded via reductive polydopamine. RSC Adv 6:91349–91360
Zhu W, Holmes B, Glazer RI, Zhang LG (2016b) 3D printed nanocomposite matrix for the study of breast cancer bone metastasis. Nanomedicine 12(1):69–79
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Bag, S. (2019). Biodegradable Composite Scaffold for Bone Tissue Regeneration. In: Paul, S. (eds) Biomedical Engineering and its Applications in Healthcare. Springer, Singapore. https://doi.org/10.1007/978-981-13-3705-5_27
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