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Functions of Insulin and the Related Signaling Pathways in the Regulation of Toxicity of Environmental Toxicants or Stresses

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Molecular Toxicology in Caenorhabditis elegans

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Abstract

In nematodes, the insulin signaling pathway can potentially participate in the regulation of various biological processes. In this chapter, we further discussed the involvement and possible pivotal function of core insulin signaling pathway in the regulation of toxicity of environmental toxicants or stresses. Moreover, we introduced the related information on the potential targets for DAF-16 and the possible upregulators for the insulin signaling pathway in regulating the toxicity of environmental toxicants or stresses. The possible formation of a large physical interaction surrounding the DAF-16 in regulating the toxicity of environmental toxicants or stresses needs to be paid more attention in nematodes.

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  1. School of Medicine, Southeast University, Nanjing, China

    Dayong Wang

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Wang, D. (2019). Functions of Insulin and the Related Signaling Pathways in the Regulation of Toxicity of Environmental Toxicants or Stresses. In: Molecular Toxicology in Caenorhabditis elegans. Springer, Singapore. https://doi.org/10.1007/978-981-13-3633-1_5

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