Skip to main content

Molecular Basis for Transgenerational Toxicity Induction of Environmental Toxicants or Stresses

  • Chapter
  • First Online:
Molecular Toxicology in Caenorhabditis elegans
  • 293 Accesses

Abstract

In the recent years, the underlying mechanisms for transgenerational toxicity of environmental toxicants or stresses have received more and more attention. We here introduced the molecular alterations during the formation of transgenerational toxicity of environmental toxicants or stresses. We also introduced molecular signal- and epigenetic signal-mediated molecular mechanisms for transgenerational toxicity of environmental toxicants or stresses. Moreover, we discussed the crucial role of intestinal barrier against the formation of transgenerational toxicity of environmental toxicants or stresses in nematodes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Wang D-Y (2018) Nanotoxicology in Caenorhabditis elegans. Springer, Singapore

    Book  Google Scholar 

  2. Ren M-X, Zhao L, Ding X-C, Krasteva N, Rui Q, Wang D-Y (2018) Developmental basis for intestinal barrier against the toxicity of graphene oxide. Part Fibre Toxicol 15:26

    Article  PubMed  PubMed Central  Google Scholar 

  3. Xiao G-S, Chen H, Krasteva N, Liu Q-Z, Wang D-Y (2018) Identification of interneurons required for the aversive response of Caenorhabditis elegans to graphene oxide. J Nanbiotechnol 16:45

    Article  Google Scholar 

  4. Ding X-C, Rui Q, Wang D-Y (2018) Functional disruption in epidermal barrier enhances toxicity and accumulation of graphene oxide. Ecotoxicol Environ Saf 163:456–464

    Article  CAS  PubMed  Google Scholar 

  5. Zhao L, Kong J-T, Krasteva N, Wang D-Y (2018) Deficit in epidermal barrier induces toxicity and translocation of PEG modified graphene oxide in nematodes. Toxicol Res 7(6):1061–1070. https://doi.org/10.1039/C8TX00136G

    Article  CAS  Google Scholar 

  6. Shao H-M, Han Z-Y, Krasteva N, Wang D-Y (2018) Identification of signaling cascade in the insulin signaling pathway in response to nanopolystyrene particles. Nanotoxicology in press

    Google Scholar 

  7. Qu M, Xu K-N, Li Y-H, Wong G, Wang D-Y (2018) Using acs-22 mutant Caenorhabditis elegans to detect the toxicity of nanopolystyrene particles. Sci Total Environ 643:119–126

    Article  CAS  PubMed  Google Scholar 

  8. Dong S-S, Qu M, Rui Q, Wang D-Y (2018) Combinational effect of titanium dioxide nanoparticles and nanopolystyrene particles at environmentally relevant concentrations on nematodes Caenorhabditis elegans. Ecotoxicol Environ Saf 161:444–450

    Article  CAS  PubMed  Google Scholar 

  9. Xiao G-S, Zhao L, Huang Q, Yang J-N, Du H-H, Guo D-Q, Xia M-X, Li G-M, Chen Z-X, Wang D-Y (2018) Toxicity evaluation of Wanzhou watershed of Yangtze Three Gorges Reservior in the flood season in Caenorhabditis elegans. Sci Rep 8:6734

    Article  PubMed  PubMed Central  Google Scholar 

  10. Xiao G-S, Zhao L, Huang Q, Du H-H, Guo D-Q, Xia M-X, Li G-M, Chen Z-X, Wang D-Y (2018) Biosafety assessment of water samples from Wanzhou watershed of Yangtze Three Gorges Reservior in the quiet season in Caenorhabditis elegans. Sci Rep 8:14102

    Article  PubMed  PubMed Central  Google Scholar 

  11. Yin J-C, Liu R, Jian Z-H, Yang D, Pu Y-P, Yin L-H, Wang D-Y (2018) Di (2-ethylhexyl) phthalate-induced reproductive toxicity involved in DNA damage-dependent oocyte apoptosis and oxidative stress in Caenorhabditis elegans. Ecotoxicol Environ Saf 163:298–306

    Article  CAS  PubMed  Google Scholar 

  12. Xiao G-S, Zhi L-T, Ding X-C, Rui Q, Wang D-Y (2017) Value of mir-247 in warning graphene oxide toxicity in nematode Caenorhabditis elegans. RSC Adv 7:52694–52701

    Article  CAS  Google Scholar 

  13. Wu Q-L, Han X-X, Wang D, Zhao F, Wang D-Y (2017) Coal combustion related fine particulate matter (PM2.5) induces toxicity in Caenorhabditis elegans by dysregulating microRNA expression. Toxicol Res 6:432–441

    Article  CAS  Google Scholar 

  14. Wang Y, Xie W, Wang D-Y (2007) Transferable properties of multi-biological toxicity caused by cobalt exposure in Caenorhabditis elegans. Environ Toxicol Chem 26:2405–2412

    Article  CAS  PubMed  Google Scholar 

  15. Wang D-Y, Shen L-L, Wang Y (2007) The phenotypic and behavioral defects can be transferred from zinc exposed nematodes to their progeny. Environ Toxicol Pharmacol 24:223–230

    Article  CAS  PubMed  Google Scholar 

  16. Wang D-Y, Yang P (2007) The multi-biological defects caused by lead exposure exhibit transferable properties from exposed parents to their progeny in Caenorhabditis elegans. J Environ Sci 19:1367–1372

    Article  CAS  Google Scholar 

  17. Wang D-Y, Wang Y (2008) Nickel sulfate induces numerous defects in Caenorhabditis elegans that can also be transferred to progeny. Environ Pollut 151:585–592

    Article  CAS  PubMed  Google Scholar 

  18. Kim SW, Kwak JI, An YJ (2013) Multigenerational study of gold nanoparticles in Caenorhabditis elegans: transgenerational effect of maternal exposure. Environ Sci Technol 47:5393–5399

    Article  CAS  PubMed  Google Scholar 

  19. Zhao Y-L, Lin Z-Q, Jia R-H, Li G-J, Xi Z-G, Wang D-Y (2014) Transgenerational effects of traffic-related fine particulate matter (PM2.5) on nematode Caenorhabditis elegans. J Hazard Mater 274:106–114

    Article  CAS  PubMed  Google Scholar 

  20. Schultz CL, Wamucho A, Tsyusko OV, Unrine JM, Crossley A, Svendsen C, Spurgeon DJ (2016) Multigenerational exposure to silver ions and silver nanoparticles reveals heightened sensitivity and epigenetic memory in Caenorhabditis elegans. Proc Biol Sci B 283:20152911

    Article  Google Scholar 

  21. Wu Q-L, Zhao Y-L, Li Y-P, Wang D-Y (2014) Molecular signals regulating translocation and toxicity of graphene oxide in the nematode Caenorhabditis elegans. Nanoscale 6:11204–11212

    Article  CAS  PubMed  Google Scholar 

  22. Yu Z, Chen X, Zhang J, Wang R, Yin D (2013) Transgenerational effects of heavy metals on L3 larva of Caenorhabditis elegans with greater behavior and growth inhibitions in the progeny. Ecotoxicol Environ Saf 88:178–184

    Article  CAS  PubMed  Google Scholar 

  23. Taki FA, Pan X, Zhang B (2013) Nicotine exposure caused significant transgenerational heritable behavioral changes in Caenorhabditis elegans. EXCLI J 12:793–806

    PubMed  PubMed Central  Google Scholar 

  24. Min H, Sung M, Son M, Kawasaki I, Shim YH (2017) Transgenerational effects of proton beam irradiation on Caenorhabditis elegans germline apoptosis. Biochem Biophys Res Commun 490:608–615

    Article  CAS  PubMed  Google Scholar 

  25. Buisset-Goussen A, Goussen B, Della-Vedova C, Galas S, Adam-Guillermin C, Lecomte-Pradines C (2014) Effects of chronic gamma irradiation: a multigenerational study using Caenorhabditis elegans. J Environ Radioact 137:190–197

    Article  CAS  PubMed  Google Scholar 

  26. Dong Zhou D, Yang J, Li H, Lu Q, Liu Y, Lin K (2016) Ecotoxicity of bisphenol A to Caenorhabditis elegans by multigenerational exposure and variations of stress response in vivo across generations. Environ Pollut 208:767–773

    Article  PubMed  Google Scholar 

  27. Taki FA, Pan X, Lee MH, Zhang B (2014) Nicotine exposure and transgenerational impact: a prospective study on small regulatory microRNAs. Sci Rep 4:7513

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Zhi L-T, Fu W, Wang X, Wang D-Y (2016) ACS-22, a protein homologous to mammalian fatty acid transport protein 4, is essential for the control of toxicity and translocation of multi-walled carbon nanotubes in Caenorhabditis elegans. RSC Adv 6:4151–4159

    Article  CAS  Google Scholar 

  29. Zhao Y-L, Yu X-M, Jia R-H, Yang R-L, Rui Q, Wang D-Y (2015) Lactic acid bacteria protects Caenorhabditis elegans from toxicity of graphene oxide by maintaining normal intestinal permeability under different genetic backgrounds. Sci Rep 5:17233

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Liu Z-F, Zhou X-F, Wu Q-L, Zhao Y-L, Wang D-Y (2015) Crucial role of intestinal barrier in the formation of transgenerational toxicity in quantum dots exposed nematodes Caenorhabditis elegans. RSC Adv 5:94257–94266

    Article  CAS  Google Scholar 

  31. Ni JZ, Kalinava N, Chen E, Huang A, Trinh T, Gu SG (2016) A transgenerational role of the germline nuclear RNAi pathway in repressing heat stress-induced transcriptional activation in C. elegans. Epigenetics Chromatin 9:3

    Article  PubMed  PubMed Central  Google Scholar 

  32. Wu Q-L, Cao X-O, Yan D, Wang D-Y, Aballay A (2015) Genetic screen reveals link between maternal-effect sterile gene mes-1 and P. aeruginosa-induced neurodegeneration in C. elegans. J Biol Chem 290:29231–29239

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Yu Y-L, Zhi L-T, Guan X-M, Wang D-Y, Wang D-Y (2016) FLP-4 neuropeptide and its receptor in a neuronal circuit regulate preference choice through functions of ASH-2 trithorax complex in Caenorhabditis elegans. Sci Rep 6:21485

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Sun L-M, Zhi L-T, Shakoor S, Liao K, Wang D-Y (2016) microRNAs involved in the control of innate immunity in Candida infected Caenorhabditis elegans. Sci Rep 6:36036

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Sun L-M, Liao K, Li Y-P, Zhao L, Liang S, Guo D, Hu J, Wang D-Y (2016) Synergy between PVP-coated silver nanoparticles and azole antifungal against drug-resistant Candida albicans. J Nanosci Nanotechnol 16:2325–2335

    Article  CAS  PubMed  Google Scholar 

  36. Sun L-M, Liao K, Hong C-C, Wang D-Y (2017) Honokiol induces reactive oxygen species-mediated apoptosis in Candida albicans through mitochondrial dysfunction. PLoS ONE 12:e0172228

    Article  PubMed  PubMed Central  Google Scholar 

  37. Sun L-M, Liao K, Wang D-Y (2017) Honokiol induces superoxide production by targeting mitochondrial respiratory chain complex I in Candida albicans. PLoS ONE 12:e0184003

    Article  PubMed  PubMed Central  Google Scholar 

  38. Zhi L-T, Yu Y-L, Li X-Y, Wang D-Y, Wang D-Y (2017) Molecular control of innate immune response to Pseudomonas aeruginosa infection by intestinal let-7 in Caenorhabditis elegans. PLoS Pathog 13:e1006152

    Article  PubMed  PubMed Central  Google Scholar 

  39. Zhi L-T, Yu Y-L, Jiang Z-X, Wang D-Y (2017) mir-355 functions as an important link between p38 MAPK signaling and insulin signaling in the regulation of innate immunity. Sci Rep 7:14560

    Article  PubMed  PubMed Central  Google Scholar 

  40. Yu Y-L, Zhi L-T, Wu Q-L, Jing L-N, Wang D-Y (2018) NPR-9 regulates innate immune response in Caenorhabditis elegans by antagonizing activity of AIB interneurons. Cell Mol Immunol 15:27–37

    Article  CAS  PubMed  Google Scholar 

  41. Palominos MF, Verdugo L, Gabaldon C, Pollak B, Ortíz-Severín J, Varas MA, Chávez FP, Calixto A (2017) Transgenerational diapause as an avoidance strategy against bacterial pathogens in Caenorhabditis elegans. MBio 8:e01234–e01217

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Yu C, Liao VH (2016) Transgenerational reproductive effects of arsenite are associated with H3K4 dimethylation and SPR-5 downregulation in Caenorhabditis elegans. Environ Sci Technol 50:10673–10681

    Article  CAS  PubMed  Google Scholar 

  43. Kishimoto S, Uno M, Okabe E, Nono M, Nishida E (2016) Environmental stresses induce transgenerationally inheritable survival advantages via germline-tosoma communication in Caenorhabditis elegans. Nat Commun 8:14031

    Article  Google Scholar 

  44. Yang J, Chatterjee N, Kim Y, Roh J, Kwon J, Park M, Choi J (2018) Histone methylation-associated transgenerational inheritance of reproductive defects in Caenorhabditis elegans exposed to crude oil under various exposure scenarios. Chemosphere 200:358–365

    Article  CAS  PubMed  Google Scholar 

  45. Klosin A, Casas E, Hidalgo-Carcedo C, Vavouri T, Lehner B (2017) Transgenerational transmission of environmental information in C. elegans. Science 356:320–323

    Article  CAS  PubMed  Google Scholar 

  46. Frazier HN III, Roth MB (2009) Adaptive sugar provisioning controls survival of C. elegans embryos in adverse environments. Curr Biol 19:859–863

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Burton NO, Furuta T, Webster AK, Kaplan REW, Baugh LR, Arur S, Horvitz HR (2017) Insulin-like signalling to the maternal germline controls progeny response to osmotic stress. Nat Cell Biol 19:252–257

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Wang, D. (2019). Molecular Basis for Transgenerational Toxicity Induction of Environmental Toxicants or Stresses. In: Molecular Toxicology in Caenorhabditis elegans. Springer, Singapore. https://doi.org/10.1007/978-981-13-3633-1_15

Download citation

Publish with us

Policies and ethics