Abstract
Allied disorders of Hirschsprung’s disease (ADHD) have been proposed to be the concept of the functional obstruction of the intestine with the presence of ganglion cells in the terminal rectum. Coordinated action of the enteric nervous system (ENS), interstitial cells of Cajal (ICC), and smooth muscle cells (SMCs) is indispensable to normal gastrointestinal motility. Developmental defects affecting specific cell types or disturbing proper functioning of the ENS, ICC, or SMCs may result in variable degrees of abnormal motility, eventually leading to the development of intestinal neuromuscular disorders. In this chapter, we will discuss an overview of genetics of ADHD.
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Kirino, K., Yoshimaru, K. (2019). Genetic Aspect of Allied Disorders of Hirschsprung’s Disease. In: Taguchi, T., Matsufuji, H., Ieiri, S. (eds) Hirschsprung’s Disease and the Allied Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-13-3606-5_35
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DOI: https://doi.org/10.1007/978-981-13-3606-5_35
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