Abstract
Cervical cancer screening of women of appropriate age followed by treatment of the screen-detected abnormalities can significantly reduce the incidence of cervical cancer and also the mortality from the disease. Colposcopy is an important triage tool interposed between screening and histopathological diagnosis and treatment; therefore, a thorough knowledge of the procedure is essential for the providers. The characteristics of cervical intraepithelial neoplasia (CIN) on colposcopy depend on the grade of the lesion, and its diagnosis can be mastered by the providers with the help of the subject knowledge, clinical practice and self-evaluation by colposcopic-histopathological correlation. The key features that are evaluated during colposcopy are acetowhiteness, blood vessels, iodine staining, margin/surface of the lesion and lesion size. The International Federation of Cervical Pathology and Colposcopy (IFCPC) introduced a new system of nomenclature for colposcopy in the year 2011, in which the abnormal findings have been categorized as grade 1 or minor findings, grade 2 or major findings, suspected invasion and non-specific findings. The benign abnormalities have been grouped as miscellaneous findings. Describing the type of transformation zone and the final scoring of the abnormalities using the ‘Swede score’ has been made mandatory in the new nomenclature system.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Abbreviations
- AIS:
-
Adenocarcinoma-in-situ
- CIN:
-
Cervical intraepithelial neoplasia
- HPV:
-
Human papillomavirus
- IFCPC:
-
The International Federation of Cervical Pathology and Colposcopy
- SCJ:
-
Squamocolumnar junction
- TZ:
-
Transformation zone
- VIA:
-
Visual inspection with acetic acid
- WHO:
-
The World Health Organization
References
Schiffman M, Kjaer SK. Chapter 2: Natural history of anogenital human papillomavirus infection and neoplasia. J Natl Cancer Inst Monogr. 2003;31:14–9.
Wheeler CM. Natural history of human papillomavirus infections, cytologic and histologic abnormalities, and cancer. Obstet Gynecol Clin N Am. 2008;35(4):519–36.
Koutsky LA, Holmes KK, Critchlow CW, Stevens CE, Paavonen J, Beckmann AM, et al. A cohort study of the risk of cervical intraepithelial neoplasia grade 2 or 3 in relation to papillomavirus infection. N Engl J Med. 1992;327(18):1272–8.
Kiviat NB, Koutsky LA. Specific human papillomavirus types as the causal agents of most cervical intraepithelial neoplasia: implications for current views and treatment. J Natl Cancer Inst. 1993;85(12):934–5.
Kiviat NB, Critchlow CW, Kurman RJ. Reassessment of the morphological continuum of cervical intraepithelial lesions: does it reflect different stages in the progression to cervical carcinoma? IARC Sci Publ. 1992;119:59–66.
Park J, Sun D, Genest DR, Trivijitsilp P, Suh I, Crum CP. Coexistence of low and high grade squamous intraepithelial lesions of the cervix: morphologic progression or multiple papillomaviruses? Gynecol Oncol. 1998;70(3):386–91.
Winer RL, Kiviat NB, Hughes JP, Adam DE, Lee SK, Kuypers JM, et al. Development and duration of human papillomavirus lesions, after initial infection. J Infect Dis. 2005;191(5):731–8.
Crum CP. Contemporary theories of cervical carcinogenesis: the virus, the host, and the stem cell. Mod Pathol. 2000;13(3):243–51.
Jeronimo J, Massad LS, Castle PE, Wacholder S, Schiffman M. Interobserver agreement in the evaluation of digitized cervical images. Obstet Gynecol. 2007;110(4):833–40.
Ferris DG, Litaker M. Interobserver agreement for colposcopy quality control using digitized colposcopic images during the ALTS trial. J Low Genit Tract Dis. 2005;9(1):29–35.
Massad LS, Jeronimo J, Schiffman M. Interobserver agreement in the assessment of components of colposcopic grading. Obstet Gynecol. 2008;111(6):1279–84.
Hammes LS, Naud P, Passos EP, Matos J, Brouwers K, Rivoire W, et al. Value of the International Federation for Cervical Pathology and Colposcopy (IFCPC) Terminology in predicting cervical disease. J Low Genit Tract Dis. 2007;11(3):158–65.
Li Y, Duan X, Sui L, Xu F, Xu S, Zhang H, et al. Closer to a uniform language in colposcopy: study on the potential application of 2011 International Federation for Cervical Pathology and Colposcopy Terminology in clinical practice. Biomed Res Int. 2017;2017:8984516.
Cristiani P, Costa S, Schincaglia P, Garutti P, de Bianchi PS, Naldoni C, et al. An online quality assurance program for colposcopy in a population-based cervical screening setting in Italy: results on colposcopic impression. J Low Genit Tract Dis. 2014;18(4):309–13.
Prendiville W, Sankaranarayanan R. Colposcopy and treatment of cervical precancer, IARC technical publications, 45. Lyon: IARC; 2017.
Mitchell MF. Accuracy of colposcopy. Consult Obstet Gynecol. 1994;6:70–3.
Mustafa RA, Santesso N, Khatib R, Mustafa AA, Wiercioch W, Kehar R, et al. Systematic reviews and meta-analyses of the accuracy of HPV tests, visual inspection with acetic acid, cytology, and colposcopy. Int J Gynecol Obstet. 2016;132:259–65.
Massad LS, Halperin CJ, Bitterman P. Correlation between colposcopically directed biopsy and cervical loop excision. Gynecol Oncol. 1996;60:400–3.
Pretorius RG, Zhang WH, Belinson JL, Huang MN, Wu LY, Zhang X, et al. Colposcopically directed biopsy, random cervical biopsy, and endocervical curettage in the diagnosis of cervical intraepithelial neoplasia II or worse. Am J Obstet Gynecol. 2004;191:430–4.
Massad LS, Jeronimo J, Katki HA, Schiffman M, National Institutes of Health/American Society for Colposcopy and Cervical Pathology Research Group. The accuracy of colposcopic grading for detection of high-grade cervical intraepithelial neoplasia. J Low Genit Tract Dis. 2009;13(3):137–44.
Shastri SS, Mittra I, Mishra GA, Gupta S, Dikshit R, Singh S, et al. Effect of VIA screening by primary health workers: randomized controlled study in Mumbai, India. J Natl Cancer Inst. 2014;106(3):dju009.
Further Reading
Basu P, Sankaranarayanan R. Atlas of colposcopy: Principles and practice. Lyon: IARC; 2017. http://screening.iarc.fr/atlascolpo.php.
Sellors JW, Sankaranarayanan R. Colposcopy and treatment of cervical intraepithelial neoplasia: a beginners’ manual. Lyon: IARC; 2003.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Basu, P., Joshi, S., Poli, U. (2019). Colposcopic Features of Cervical Intraepithelial Lesions. In: Mehta, S., Singla, A. (eds) Preventive Oncology for the Gynecologist. Springer, Singapore. https://doi.org/10.1007/978-981-13-3438-2_12
Download citation
DOI: https://doi.org/10.1007/978-981-13-3438-2_12
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-3437-5
Online ISBN: 978-981-13-3438-2
eBook Packages: MedicineMedicine (R0)