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The Role of Mitochondrial Quality Imbalance in Multiple Organ Dysfunction Syndrome Following Severe Trauma, Shock, and Sepsis

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Severe Trauma and Sepsis

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Abstract

Multiple organ dysfunction syndrome (MODS) is a life-threatening condition with high morbidity and mortality. Mitochondria are multifunctional organelles, whose failure triggers multiple organ dysfunction and is directly associated with patient’s vicious outcome. Physiologically, mitochondria undergo continuous fission, fusion, biogenesis, and mitophagy (selective mitochondrial autophagy) to maintain homeostasis, whose disruption may heavily impact the mitochondrial quality and result in damaged cell and organ functions under pathological conditions such as severe trauma, shock, and sepsis. Mitochondrial quality imbalance is a key step in MODS process, and rebalancing the mitochondrial quality may be a promising approach in the treatment of MODS following severe trauma, shock, and sepsis.

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  1. State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing, P. R. China

    Lei Kuang, Liangming Liu & Tao Li

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  1. Lei Kuang
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  2. Liangming Liu
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  1. Wound Healing and Cell Biology Lab, First Affiliated Hospital, Chinese PLA General Hospital, Beijing, China

    Xiaobing Fu

  2. State Key Laboratory of Trauma, Burns, and Combined Injury, Daping Hospital, Third Military Medical University, Chong Qing, China

    Liangming Liu

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Kuang, L., Liu, L., Li, T. (2019). The Role of Mitochondrial Quality Imbalance in Multiple Organ Dysfunction Syndrome Following Severe Trauma, Shock, and Sepsis. In: Fu, X., Liu, L. (eds) Severe Trauma and Sepsis. Springer, Singapore. https://doi.org/10.1007/978-981-13-3353-8_4

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