Abstract
Event-Related Potentials (ERPs) components are widely studied to understand brain response associated with cognitive processes in terms of amplitude, latency, and brain topography. Schizophrenia is a psychiatric illness which is characterized by reduced amplitude and increased latency of P300 ERP component. In this work, we have analyzed the attributes of P300 component involved during discrimination of visual stimuli (frequent, infrequent, and rare) at midline frontal and parietal sites in 14 schizophrenic patients who were receiving remediation in psychiatric setup for a long time. The key findings include increase in P300 amplitude when infrequent and rare stimuli were presented which reflected better contribution of attentional resources toward discrimination of stimuli. The P300 latency was found to be increased at same measurement sites for standards and rares for which the responses have to be ignored. The latencies were reduced in the case of infrequent stimuli (targets) which reflected better speed of cognitive processes involved during the identification of the stimuli.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Jutzeler, C.R., Mcmullen, M.E., Featherstone, R.F., Tatardleitman, V.M., Gandal, M.J., Carlson, G.C., Siegel, S.J.: Electrophysiological Deficits in Schizophrenia: Models and Mechanisms in Psychiatric Disorders Trends and Developments. IntechOpen (2011). ISBN 978-953-307-745-1
Oribe, N., Yoji, H., Kanba, S., Del Re, E., Seidman, L., Mesholam-Gately, R., Goldstein, J.M., et al.: Progressive reduction of visual P300 amplitude in patients with first-episode schizophrenia: an ERP study. Schizophr. Bull. 41(2), 460–470 (2014)
Polich, J.: Updating P300: an integrative theory of P3a and P3b. Clin. Neurophysiol. 118(10), 2128–2148 (2007)
Ford, J.M., Mathalon, D.H., Marsh, L., Faustman, W.O., Harris, D., Hoff, A.L., Beal, M., Pfefferbaum, A.: P300 amplitude is related to clinical state in severely and moderately ill patients with schizophrenia. Biol. Psychiatry 46(1), 94–101 (1999)
Rao, K.J., Ananthnarayanan, C.V., Gangadhar, B.N., Janakiramaiah, N.: Smaller auditory P300 amplitude in schizophrenics in remission. Neuropsychobiology 32(3), 171–174 (1995)
Turetsky, B.I., Cannon, T.D., Gur, R.E.: P300 subcomponent abnormalities in schizophrenia: III. Deficits in unaffected siblings of schizophrenic probands. Biol. Psychiatry 47(5), 380–390 (2000)
Faux, S.F., McCarley, R.W., Nestor, P.G., Shenton, M.E., Pollak, S.D., Penhune,V., Mondrow, E., Marcy, B., Peterson, A., Horvath, T., Davis, K.L.: P300 topographic asymmetries are present in unmedicated schizophrenics. Electroencephalogr. Clin. Neurophysiol./Evoked Potentials Sect. 88(1), 32–41 (1993)
Sahoo, S., Malhotra, S., Basu, D., Modi, M.: Auditory P300 event related potentials in acute and transient psychosis—comparison with schizophrenia. Asian J. Psychiatry 23, 8–16 (2016)
McCathern, A.: Emitted P3a and P3b in chronic schizophrenia and in first episode schizophrenia. Doctoral dissertation, University of Pittsburgh. http://dscholarship.pitt.edu/31431/ (2017)
Kim, M., Lee, T.H., Kim, J.H., Hong, H., Lee, T.Y., Lee, Y., Salisbury, D.F., Kwon, J.S.: Decomposing P300 into correlates of genetic risk and current symptoms in schizophrenia: an inter-trial variability analysis. Schizophr. Res. (2017)
Vafaii, P., Mazhari, S., Pourrahimi, A.M., Nakhaee, N.: Hemispheric differences for visual P3 amplitude in patients with schizophrenia. Neuropsychiatry (London) 6(6), 309 (2016)
Luck, S.J.: An Introduction to the Event-Related Potential Technique (Cognitive Neuroscience). The MIT Press (2005)
Jeek, P.: Database of EEG/ERP experiments: technical report no. DCSE/TR-201004. https://dspace5.zcu.cz/handle/11025/21566 (2010)
Acharya, J.N., Hani, A.J., Thirumala, P., Tsuchida, T.N.: American clinical neurophysiology society guideline 3: a proposal for standard montages to be used in clinical EEG. Neurodiagn. J. 56(4), 253–260 (2016)
Delorme, A., Palmer, J., Onton, J., Oostenveld, R., Makeig, S.: Independent EEG sources are dipolar. PLoS ONE 7(2), e30135 (2012)
Molina, G.N.G.: Direct brain-computer communication through scalp recorded EEG signals. École Polytechnique Fédérale de Lausanne (2004)
Chaumon, M., Bishop, D.V., Busch, N.A.: A practical guide to the selection of independent components of the electroencephalogram for artifact correction. J. Neurosci. Methods 250, 47–63 (2015)
Mognon, A., Jovicich, J., Bruzzone, L., Buiatti, M.: ADJUST: An automatic EEG artifact detector based on the joint use of spatial and temporal features. Psychophysiology 48(2), 229–240 (2011)
Delorme, A., Makeig, S.: EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. J. Neurosci. Methods 134(1), 9–21 (2004)
Lopez-Calderon, J., Luck, S.J.: ERPLAB: an opensource toolbox for the analysis of event-related potentials. Front. Hum. Neurosci. 8, 213 (2014)
Picton, T.W.: The P300 wave of the human event related potential. J. Clin. Neurophysiol. 9, 456–456 (1992)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Singh, J., Singh, S., Gupta, S., Chavan, B.S. (2019). Analysis of Stimuli Discrimination in Indian Patients with Chronic Schizophrenia. In: Chaki, R., Cortesi, A., Saeed, K., Chaki, N. (eds) Advanced Computing and Systems for Security. Advances in Intelligent Systems and Computing, vol 897. Springer, Singapore. https://doi.org/10.1007/978-981-13-3250-0_4
Download citation
DOI: https://doi.org/10.1007/978-981-13-3250-0_4
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-3249-4
Online ISBN: 978-981-13-3250-0
eBook Packages: Intelligent Technologies and RoboticsIntelligent Technologies and Robotics (R0)