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The Wrappers of the 1,2-Propanediol Utilization Bacterial Microcompartments

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Biochemical and Biophysical Roles of Cell Surface Molecules

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1112))

Abstract

The propanediol utilization bacterial microcompartments are specialized protein-based organelles in Salmonella that facilitate the catabolism of 1,2-propanediol when available as the sole carbon source. This smart prokaryotic cell organelle compartmentalizes essential enzymes and substrates in a volume of a few attoliters compared to the femtoliter volume of a bacterial cell thereby enhancing the enzyme kinetics and properly orchestrating the downstream pathways. A shell or coat, which is composed of a few thousand protein subunits, wraps a chain of consecutively acting enzymes and serves as ducts for the diffusion of substrates, cofactors, and products into and out of the core of the microcompartment. In this article we bring together the properties of the wrappers of the propanediol utilization bacterial microcompartments to update our understanding on the mechanism of the formation of these unique wraps, their assembly, and interaction with the encapsulated enzymes.

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Authors and Affiliations

  1. Institute of Nano Science and Technology, Mohali, Punjab, India

    Naimat K. Bari, Gaurav Kumar & Sharmistha Sinha

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  1. Naimat K. Bari
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  2. Gaurav Kumar
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  3. Sharmistha Sinha
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Correspondence to Sharmistha Sinha .

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Editors and Affiliations

  1. Centre for Protein Science, Design and Engineering, Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Mohali, Punjab, India

    Kausik Chattopadhyay

  2. Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA

    Subhash C. Basu

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Bari, N.K., Kumar, G., Sinha, S. (2018). The Wrappers of the 1,2-Propanediol Utilization Bacterial Microcompartments. In: Chattopadhyay, K., Basu, S. (eds) Biochemical and Biophysical Roles of Cell Surface Molecules. Advances in Experimental Medicine and Biology, vol 1112. Springer, Singapore. https://doi.org/10.1007/978-981-13-3065-0_23

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