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Biochemical and Biophysical Roles of Cell Surface Molecules pp 13–30Cite as

Multiple Roles, Multiple Adaptors: Dynein During Cell Cycle

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1112))

Abstract

Dynein is an essential protein complex present in most eukaryotes that regulate biological processes ranging from ciliary beating, intracellular transport, to cell division. Elucidating the detailed mechanism of dynein function has been a challenging task owing to its large molecular weight and high complexity of the motor. With the advent of technologies in the last two decades, studies have uncovered a wealth of information about the structural, biochemical, and cell biological roles of this motor protein. Cytoplasmic dynein associates with dynactin through adaptor proteins to mediate retrograde transport of vesicles, mRNA, proteins, and organelles on the microtubule tracts. In a mitotic cell, dynein has multiple localizations, such as at the nuclear envelope, kinetochores, mitotic spindle and spindle poles, and cell cortex. In line with this, dynein regulates multiple events during the cell cycle, such as centrosome separation, nuclear envelope breakdown, spindle assembly checkpoint inactivation, chromosome segregation, and spindle positioning. Here, we provide an overview of dynein structure and function with focus on the roles played by this motor during different stages of the cell cycle. Further, we review in detail the role of dynactin and dynein adaptors that regulate both recruitment and activity of dynein during the cell cycle.

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Acknowledgments

D.D. acknowledges financial support from the Council of Scientific and Industrial Research (CSIR)-University Grants Commission (UGC) and IISER Mohali. M.S. acknowledges financial support from the Wellcome Trust/Department of Biotechnology (DBT) India Alliance [grant number IA/I/12/1/500523] and IISER Mohali. M.S. is a recipient of the Wellcome Trust/DBT India Alliance Intermediate Fellowship and SERB Women Excellence Award.

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D.D. reviewed the literature and wrote the manuscript. M.S. helped in literature review and in writing and editing the manuscript. The authors declare no competing financial interests.

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  1. Department of Biological Sciences, Indian Institute of Science Education and Research (IISER), Mohali, Punjab, India

    Devashish Dwivedi & Mahak Sharma

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  1. Devashish Dwivedi
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  1. Centre for Protein Science, Design and Engineering, Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Mohali, Punjab, India

    Kausik Chattopadhyay

  2. Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA

    Subhash C. Basu

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Dwivedi, D., Sharma, M. (2018). Multiple Roles, Multiple Adaptors: Dynein During Cell Cycle. In: Chattopadhyay, K., Basu, S. (eds) Biochemical and Biophysical Roles of Cell Surface Molecules. Advances in Experimental Medicine and Biology, vol 1112. Springer, Singapore. https://doi.org/10.1007/978-981-13-3065-0_2

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