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Chemotherapy for Metastatic Colorectal Cancer

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Abstract

The overall survival of patients with unresectable metastatic colorectal cancer (mCRC) has increased from approximately 1 year during the era of fluoropyrimidine monotherapy to >30 months with the combination of cytotoxic agents and molecular-targeted agents. Here, we review the current landscape of chemotherapy for mCRC. The recent establishment of late-line chemotherapy, including regorafenib and TAS-102, and development of biomarker analysis have attracted much attention. Maintenance and rechallenge are relatively new concepts. The former has been developed for less-invasive treatment and the latter because performance status of patients with mCRC is good beyond standard second-line chemotherapy.

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Authors and Affiliations

  1. Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan

    Takeshi Yamada, Michihiro Koizumi, Seiichi Shinji, Akihisa Matsuda, Yasuyuki Yokoyama, Goro Takahashi, Takuma Iwai, Keisuke Hara, Masahiro Hotta, Kohki Takeda, Kohji Ueda & Hiroshi Yoshida

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  1. Takeshi Yamada
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  2. Michihiro Koizumi
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  12. Hiroshi Yoshida
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Correspondence to Takeshi Yamada .

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Editors and Affiliations

  1. Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan

    Hideyuki Ishida

  2. Department of Surgery, Teikyo University Chiba Medical Center, Ichihara, Chiba, Japan

    Keiji Koda

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Yamada, T. et al. (2019). Chemotherapy for Metastatic Colorectal Cancer. In: Ishida, H., Koda, K. (eds) Recent Advances in the Treatment of Colorectal Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-13-3050-6_9

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  • DOI: https://doi.org/10.1007/978-981-13-3050-6_9

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