Abstract
In surgical pathology, an understanding of the normal ovarian anatomy and the range of nonneoplastic lesions of the ovary is essential during the examination of gynecological specimens. Pathologists routinely evaluate nonneoplastic adult ovaries as components of (1) hysterectomy procedures for uterine leiomyomata, uterine prolapse, vaginal bleeding, or gynecological cancer and (2) risk-reducing prophylactic salpingo-oophorectomy, with the primary goals of excluding ovarian malignancy and/or determining whether the ovary is the source of hormone production driving uterine cancer. In these scenarios, with the exception of endometriosis, ovarian infection, or a hormone-producing lesion, any incidental nonneoplastic lesion encountered in the ovary is likely not of clinical significance. However, another frequently encountered scenario is examination of the ovary via biopsy, cystectomy, or excision for a specific purpose, including ovarian enlargement, cyst formation, masses, torsion, infection, infertility, or ectopic pregnancy, in which the ovary is submitted for evaluation for a clinical or radiological reason. Each of these settings requires the pathologist to have knowledge of the normal ovarian anatomy, the histology, and the range of nonneoplastic lesions of the ovary in order to guide the obstetrician-gynecologist or gynecologic oncologist to the appropriate treatment and follow-up.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Boss JH, Scully RE, Wegner KH, Cohen RB. Structural Variations in the adult ovary. Clinical significance. Obstet Gynecol. 1965;25:747–64.
Tong G-X, Hamele-Bena D. The differential expression of PAX2 and PAX8 in the ovarian surface epithelium and fallopian tubal epithelium is an important issue. Am J Surg Pathol. 2012;36:1099–100.
Ozcan A, Liles N, Coffey D, Shen SS, Truong LD. PAX2 and PAX8 expression in primary and metastatic Müllerian epithelial Tumors. Am J Surg Pathol. 2011;35:1837–47.
Judd HL, Lucas WE, Yen SS. Effect of oophorectomy on circulating testosterone and androstenedione levels in patients with endometrial cancer. Am J Obstet Gynecol. 1974;118:793–8.
Lucisano A, Russo N, Acampora MG, Fabiano A, Fattibene M, Parlati E, Maniccia E, Dell’Acqua S. Ovarian and peripheral androgen and oestrogen levels in post-menopausal women: correlations with ovarian histology. Maturitas. 1986;8:57–65.
Carrasco-Juan JL, Álvarez-Argüelles Cabrera H, Martín Corriente MC, González-Gómez M, Valladares Parrilla R, Gutiérrez García R, Díaz-Flores L. Ovarian Leydig cells (OLC): a histomorphological and immunohistochemical study. Histol Histopathol. 2017;32:1089–97.
Sternberg WH. The morphology, androgenic function, hyperplasia, and tumors of the human ovarian hilus cells. Am J Pathol. 1949;25:493–521.
Russo L, Woolmough E, Heatley MK. Structural and cell surface antigen expression in the rete ovarii and epoophoron differs from that in the Fallopian tube and in endometriosis. Histopathology. 2000;37:64–9.
Goyal A, Masand RP, Roma AA. Value of PAX-8 and SF-1 immunohistochemistry in the distinction between female adnexal tumor of probable Wolffian origin and its mimics. Int J Gynecol Pathol. 2016;35:167–75.
Kaipia A, Hsueh AJ. Regulation of ovarian follicle atresia. Annu Rev Physiol. 1997;59:349–63.
Quirk SM, Cowan RG, Harman RM, Hu C-L, Porter DA. Ovarian follicular growth and atresia: the relationship between cell proliferation and survival. J Anim Sci. 2004;82(E-Suppl):E40–52.
Clarke-Pearson DL. Screening for ovarian cancer. N Engl J Med. 2009;361:170–7.
Ferenczy A, Bergeron C. Histology of the human endometrium: from birth to senescence. Ann N Y Acad Sci. 1991;622:6–27.
Walton KL, Makanji Y, Robertson DM, Harrison CA. The synthesis and secretion of inhibins. Vitam Horm. 2011;85:149–84.
Dos Reis FM, De Rezende CP. Clinical usefulness of inhibin assays in gynecology and obstetrics. Rev Bras Ginecol Obstet. 2009;31:621–5.
Kwok R, Johnson NP. Ovarian biopsy has no role as a routine diagnostic test of ovarian reserve: a systematic review. Reprod Biomed Online. 2012;24:492–5.
Steiner A. Biomarkers of ovarian reserve as predictors of reproductive potential. Semin Reprod Med. 2013;31:437–42.
Dumont A, Robin G, Catteau-Jonard S, Dewailly D. Role of anti-Müllerian hormone in pathophysiology, diagnosis and treatment of polycystic ovary syndrome: a review. Reprod Biol Endocrinol. 2015;13:137.
Dewailly D, Andersen CY, Balen A, et al. The physiology and clinical utility of anti-Müllerian hormone in women. Hum Reprod Update. 2014;20:370–85.
Nelson WW, Greene RR. Some observations on the histology of the human ovary during pregnancy. Am J Obstet Gynecol. 1958;76:66–90.
Burandt E, Young RH. Pregnancy luteoma: a study of 20 cases on the occasion of the 50th anniversary of its description by Dr. William H. Sternberg, with an emphasis on the common presence of follicle-like spaces and their diagnostic implications. Am J Surg Pathol. 2014;38:239–44.
Norris HJ, Taylor HB. Nodular theca-lutein hyperplasia of pregnancy (so-called “pregnancy luteoma”). A clinical and pathologic study of 15 cases. Am J Clin Pathol. 1967;47:557–66.
Garcia-Bunuel R, Berek JS, Woodruff JD. Luteomas of pregnancy. Obstet Gynecol. 1975;45:407–14.
Choi JR, Levine D, Finberg H. Luteoma of pregnancy: sonographic findings in two cases. J Ultrasound Med. 2000;19:877–81.
Joshi R, Dunaif A. Ovarian disorders of pregnancy. Endocrinol Metab Clin N Am. 1995;24:153–69.
Malinowski AK, Sen J, Sermer M. Hyperreactio luteinalis: maternal and fetal effects. J Obstet Gynaecol Can. 2015;37:715–23.
Cavoretto P, Giorgione V, Sigismondi C, Mangili G, Serafini A, Dallagiovanna C, Candiani M. Hyperreactio luteinalis: timely diagnosis minimizes the risk of oophorectomy and alerts clinicians to the associated risk of placental insufficiency. Eur J Obstet Gynecol Reprod Biol. 2014;176:10–6.
Clement PB, Scully RE. Large solitary luteinized follicle cyst of pregnancy and puerperium: a clinicopathological analysis of eight cases. Am J Surg Pathol. 1980;4:431–8.
Lomme M, Kostadinov S, Zhang C. Large solitary luteinized follicle cyst of pregnancy and puerperium: report of two cases. Diagn Pathol. 2011;6:3.
Fang YMV, Gomes J, Lysikiewicz A, Maulik D. Massive luteinized follicular cyst of pregnancy. Obstet Gynecol. 2005;105:1218–21.
Shi J, Whyte WA, Zepeda-Mendoza CJ, et al. Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes Dev. 2013;27:2648–62.
Herr JC, Heidger PM, Scott JR, Anderson JW, Curet LB, Mossman HW. Decidual cells in the human ovary at term. I. Incidence, gross anatomy and ultrastructural features of merocrine secretion. Am J Anat. 1978;152:7–27.
Ober WB, Grady HG, Schoenbucher AK. Ectopic ovarian decidua without pregnancy. Am J Pathol. 33:199–217.
Suster S, Moran CA. Deciduosis of the appendix. Am J Gastroenterol. 1990;85:841–5.
Clement PB. Tumor-like lesions of the ovary associated with pregnancy. Int J Gynecol Pathol. 1993;12:108–15.
Kondi-Pafiti A, Grapsa D, Kontogianni-Katsarou K, Papadias K, Kairi-Vassilatou E. Ectopic decidua mimicking metastatic lesions--report of three cases and review of the literature. Eur J Gynaecol Oncol. 2005;26:459–61.
Clement PB, Young RH, Scully RE. Ovarian granulosa cell proliferations of pregnancy: a report of nine cases. Hum Pathol. 1988;19:657–62.
Satyanarayana S, Bohre JK. Ovarian granulosa cell “tumorlet” and mature follicles with ectopic decidua in pregnancy—a case report. Indian J Pathol Microbiol. 2001;44:149–50.
Bouyer J, Coste J, Fernandez H, Pouly JL, Job-Spira N. Sites of ectopic pregnancy: a 10 year population-based study of 1800 cases. Hum Reprod. 2002;17:3224–30.
Scutiero G, Di Gioia P, Spada A, Greco P. Primary ovarian pregnancy and its management. J Soc Laparoendosc Surg. 2012;16:492–4.
Herbertsson G, Magnusson SS, Benediktsdottir K. Ovarian pregnancy and IUCD use in a defined complete population. Acta Obstet Gynecol Scand. 1987;66:607–10.
Raziel A, Golan A, Pansky M, Ron-El R, Bukovsky I, Caspi E. Ovarian pregnancy: a report of twenty cases in one institution. Am J Obstet Gynecol. 1990;163:1182–5.
Wang Y, Chen H, Zhao M, Fadare O, Zheng W. Primary ovarian pregnancy. Int J Gynecol Pathol. 2018; https://doi.org/10.1097/PGP.0000000000000482.
Nippita TA, Baber RJ. Premature ovarian failure: a review. Climacteric. 2007;10:11–22.
Sun W, Stegmann BJ, Henne M, Catherino WH, Segars JH. A new approach to ovarian reserve testing. Fertil Steril. 2008;90:2196–202.
Massin N, Gougeon A, Meduri G, et al. Significance of ovarian histology in the management of patients presenting a premature ovarian failure. Hum Reprod. 2004;19:2555–60.
Silva CA, Yamakami LYS, Aikawa NE, Araujo DB, Carvalho JF, Bonfá E. Autoimmune primary ovarian insufficiency. Autoimmun Rev. 2014;13:427–30.
Welt CK, Falorni A, Taylor AE, Martin KA, Hall JE. Selective theca cell dysfunction in autoimmune oophoritis results in multifollicular development, decreased estradiol, and elevated inhibin B levels. J Clin Endocrinol Metab. 2005;90:3069–76.
La Marca A, Brozzetti A, Sighinolfi G, Marzotti S, Volpe A, Falorni A. Primary ovarian insufficiency: autoimmune causes. Curr Opin Obstet Gynecol. 2010;22:1.
Bannatyne P, Russell P, Shearman RP. Autoimmune oophoritis: a clinicopathologic assessment of 12 cases. Int J Gynecol Pathol. 1990;9:191–207.
Sedmak DD, Hart WR, Tubbs RR. Autoimmune oophoritis: a histopathologic study of involved ovaries with immunologic characterization of the mononuclear cell infiltrate. Int J Gynecol Pathol. 1987;6:73–81.
Lewis J. Eosinophilic perifolliculitis: a variant of autoimmune oophoritis? Int J Gynecol Pathol. 1993;12:360–4.
Aittomäki K, Lucena JL, Pakarinen P, et al. Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure. Cell. 1995;82:959–68.
Lourenço D, Brauner R, Lin L, et al. Mutations in NR5A1 associated with ovarian insufficiency. N Engl J Med. 2009;360:1200–10.
Levine MA, Downs RW, Moses AM, Breslau NA, Marx SJ, Lasker RD, Rizzoli RE, Aurbach GD, Spiegel AM. Resistance to multiple hormones in patients with pseudohypoparathyroidism. Association with deficient activity of guanine nucleotide regulatory protein. Am J Med. 1983;74:545–56.
Aittomäki K, Herva R, Stenman UH, Juntunen K, Ylöstalo P, Hovatta O, de la Chapelle A. Clinical features of primary ovarian failure caused by a point mutation in the follicle-stimulating hormone receptor gene. J Clin Endocrinol Metab. 1996;81:3722–6.
Rogenhofer N, Pavlik R, Jeschke U, Wypior G, Ochsenkühn R, Thaler CJ. Effective ovarian stimulation in a patient with resistant ovary syndrome and antigonadotrophin antibodies. Am J Reprod Immunol. 2015;73:185–91.
Koninckx PR, Brosens IA. The “gonadotropin-resistant ovary” syndrome as a cause of secondary amenorrhea and infertility. Fertil Steril. 1977;28:926–31.
Russell P, Bannatyne P, Shearman RP, Fraser IS, Corbett P. Premature hypergonadotropic ovarian failure: clinicopathological study of 19 cases. Int J Gynecol Pathol. 1982;1:185–201.
Sheehan MT. Polycystic ovarian syndrome: diagnosis and management. Clin Med Res. 2004;2:13–27.
Strauss JF. Some new thoughts on the pathophysiology and genetics of polycystic ovary syndrome. Ann N Y Acad Sci. 2003;997:42–8.
Varanasi LC, Subasinghe A, Jayasinghe YL, Callegari ET, Garland SM, Gorelik A, Wark JD. Polycystic ovarian syndrome: prevalence and impact on the wellbeing of Australian women aged 16-29 years. Aust New Zeal J Obstet Gynaecol. 2017; https://doi.org/10.1111/ajo.12730.
Zhang X-L, Zhang C-W, Xu P, et al. SNP rs2470152 in CYP19 is correlated to aromatase activity in Chinese polycystic ovary syndrome patients. Mol Med Rep. 2012;5:245–9.
Carvalho LML, Ferreira CN, Candido AL, Reis FM, Sóter MO, Sales MF, Silva IFO, Nunes FFC, Gomes KB. Metformin reduces total microparticles and microparticles-expressing tissue factor in women with polycystic ovary syndrome. Arch Gynecol Obstet. 2017;296:617–21.
Api M. Could transvaginal, ultrasound-guided ovarian interstitial laser treatment replace laparoscopic ovarian drilling in women with polycystic ovary syndrome resistant to clomiphene citrate? Fertil Steril. 2009;92:2039–40.
Charalampakis V, Tahrani AA, Helmy A, Gupta JK, Singhal R. Polycystic ovary syndrome and endometrial hyperplasia: an overview of the role of bariatric surgery in female fertility. Eur J Obstet Gynecol Reprod Biol. 2016;207:220–6.
Lepine S, Jo J, Metwally M, Cheong YC. Ovarian surgery for symptom relief in women with polycystic ovary syndrome. Cochrane Database Syst Rev. 2017;11:CD009526.
Pasquali R, Diamanti-Kandarakis E, Gambineri A. Management of endocrine disease: secondary polycystic ovary syndrome: theoretical and practical aspects. Eur J Endocrinol. 2016;175:R157–69.
Ozkan S, Murk W, Arici A. Endometriosis and infertility. Ann N Y Acad Sci. 2008;1127:92–100.
Prentice L, Stewart A, Mohiuddin S, Johnson NP. What is endosalpingiosis? Fertil Steril. 2012;98:942–7.
Pavlik EJ, DePriest PD, Gallion HH, Ueland FR, Reedy MB, Kryscio RJ, van Nagell JR. Ovarian volume related to age. Gynecol Oncol. 2000;77:410–2.
Karam K, Hajj S. Hyperthecosis syndrome. Clinical, endocrinologic and histologic findings. Acta Obstet Gynecol Scand. 1979;58:73–9.
Sasano H, Fukunaga M, Rojas M, Silverberg SG. Hyperthecosis of the ovary. Clinicopathologic study of 19 cases with immunohistochemical analysis of steroidogenic enzymes. Int J Gynecol Pathol. 1989;8:311–20.
Snowden JA, Harkin PJ, Thornton JG, Wells M. Morphometric assessment of ovarian stromal proliferation—a clinicopathological study. Histopathology. 1989;14:369–79.
Rabban JT, Barnes M, Chen L-M, Powell CB, Crawford B, Zaloudek CJ. Ovarian pathology in risk-reducing salpingo-oophorectomies from women with BRCA mutations, emphasizing the differential diagnosis of occult primary and metastatic carcinoma. Am J Surg Pathol. 2009;33:1125–36.
Brunham RC, Gottlieb SL, Paavonen J. Pelvic inflammatory disease. N Engl J Med. 2015;372:2039–48.
Wiesenfeld HC, Hillier SL, Meyn LA, Amortegui AJ, Sweet RL. Subclinical pelvic inflammatory disease and infertility. Obstet Gynecol. 2012;120:37–43.
Furuya M, Murakami T, Sato O, Kikuchi K, Tanaka S, Shimizu M, Yoshiki T. Pseudoxanthomatous and xanthogranulomatous salpingitis of the fallopian tube: a report of four cases and a literature review. Int J Gynecol Pathol. 2002;21:56–9.
Kim SH, Kim SH, Yang DM, Kim KA. Unusual causes of tubo-ovarian abscess: CT and MR imaging findings. Radiographics. 2004;24:1575–89.
Burkman R, Schlesselman S, McCaffrey L, Gupta PK, Spence M. The relationship of genital tract actinomycetes and the development of pelvic inflammatory disease. Am J Obstet Gynecol. 1982;143:585–9.
Evans DT. Actinomyces israelii in the female genital tract: a review. Genitourin Med. 1993;69:54–9.
Boyle DP, McCluggage WG. Combined actinomycotic and pseudoactinomycotic radiate granules in the female genital tract: description of a series of cases. J Clin Pathol. 2009;62:1123–6.
Nogales-Ortiz F, Tarancón I, Nogales FF. The pathology of female genital tuberculosis. A 31-year study of 1436 cases. Obstet Gynecol. 1979;53:422–8.
Chow TWP, Lim BK, Vallipuram S. The masquerades of female pelvic tuberculosis: case reports and review of literature on clinical presentations and diagnosis. J Obstet Gynaecol Res. 2002;28:203–10.
Mahdavi A, Malviya VK, Herschman BR. Peritoneal tuberculosis disguised as ovarian cancer: an emerging clinical challenge. Gynecol Oncol. 2002;84:167–70.
Bhanothu V, Theophilus JP, Rozati R. Use of endo-ovarian tissue biopsy and pelvic aspirated fluid for the diagnosis of female genital tuberculosis by conventional versus molecular methods. PLoS One. 2014;9:e98005.
Morrison JC, Givens JR, Wiser WL, Fish SA. Mumps oophoritis: a cause of premature menopause. Fertil Steril. 1975;26:655–9.
Subietas A, Deppisch LM, Astarloa J. Cytomegalovirus oophoritis: ovarian cortical necrosis. Hum Pathol. 1977;8:285–92.
Tutschka BG, Lauchlan SC. Endosalpingiosis. Obstet Gynecol. 1980;55:57S–60S.
Kaneda S, Fujii S, Nosaka K, Inoue C, Tanabe Y, Matsuki T, Ogawa T. MR imaging findings of mass-forming endosalpingiosis in both ovaries: a case report. Abdom Imaging. 2015;40:471–4.
Li J, Abushahin N, Pang S, Xiang L, Chambers SK, Fadare O, Kong B, Zheng W. Tubal origin of “ovarian” low-grade serous carcinoma. Mod Pathol. 2011;24:1488–99.
Banet N, Kurman RJ. Two types of ovarian cortical inclusion cysts. Int J Gynecol Pathol. 2015;34:3–8.
Esselen KM, Ng S-K, Hua Y, White M, Jimenez CA, Welch WR, Drapkin R, Berkowitz RS, Ng S-W. Endosalpingiosis as it relates to tubal, ovarian and serous neoplastic tissues: an immunohistochemical study of tubal and Müllerian antigens. Gynecol Oncol. 2014;132:316–21.
Valle RF, Sciarra JJ. Endometriosis: treatment strategies. Ann N Y Acad Sci. 2003;997:229–39.
Cohen I, Figer A, Tepper R, Shapira J, Altaras MM, Yigael D, Beyth Y. Ovarian overstimulation and cystic formation in premenopausal tamoxifen exposure: comparison between tamoxifen-treated and nontreated breast cancer patients. Gynecol Oncol. 1999;72:202–7.
Bolli P, Schädelin S, Holland-Cunz S, Zimmermann P. Ovarian torsion in children: development of a predictive score. Medicine (Baltimore). 2017;96:e8299.
Ron-El R, Herman A, Golan A, Raziel A, Soffer Y, Caspi E. Follicle cyst formation following long-acting gonadotropin-releasing hormone analog administration. Fertil Steril. 1989;52:1063–6.
Morales C, García-Pardo L, Reymundo C, Bellido C, Sánchez-Criado JE, Gaytán F. Different patterns of structural luteolysis in the human corpus luteum of menstruation. Hum Reprod. 2000;15:2119–28.
Beyth Y, Klein Z, Tepper R, Weinstein S, Aviram R. Hemorrhagic corpus luteum is associated with ovarian edema. J Pediatr Adolesc Gynecol. 2006;19:325–7.
Yamakami LYS, de Araujo DB, Silva CA, Baracat EC, de Carvalho JF. Severe hemorrhagic corpus luteum complicating anticoagulation in antiphospholipid syndrome. Lupus. 2011;20:523–6.
Hatipoglu S, Hatipoglu F, Abdullayev R. Acute right lower abdominal pain in women of reproductive age: clinical clues. World J Gastroenterol. 2014;20:4043–9.
Suh DS, Han SE, Yun KY, Lee NK, Kim KH, Yoon MS. Ruptured hemorrhagic corpus luteum cyst in an undescended ovary: a rare cause of acute abdomen. J Pediatr Adolesc Gynecol. 2016;29:e21–4.
Spinelli C, Di Giacomo M, Mucci N, Massart F. Hemorrhagic corpus luteum cysts: an unusual problem for pediatric surgeons. J Pediatr Adolesc Gynecol. 2009;22:163–7.
Lee MS, Moon MH, Woo H, Sung CK, Jeon HW, Lee TS. Ruptured corpus luteal cyst: prediction of clinical outcomes with CT. Korean J Radiol. 2017;18:607–14.
Millet J, Much M, Gunabushanam G, Buza N, Schwartz PE, Scoutt LM. Large ovarian calcifications from an unresorbed corpus albicans. J Ultrasound Med. 2012;31:1465–8.
Harrison BT, Berg RE, Mittal K. Massive ovarian edema associated with a broad ligament leiomyoma: a case report and review. Int J Gynecol Pathol. 2014;33:418–22.
Harke AB, Sigamani K, Thukkaram C, Ramamurthy M, Sekar M. Massive ovarian oedema—a case report. J Clin Diagn Res. 2016;10:ED03–4.
Dahmoush H, Anupindi SA, Pawel BR, Chauvin NA. Multimodality imaging findings of massive ovarian edema in children. Pediatr Radiol. 2017;47:576–83.
Machairiotis N, Stylianaki A, Kouroutou P, et al. Massive ovarian oedema: a misleading clinical entity. Diagn Pathol. 2016;11:18.
Praveen R, Pallavi V, Rajashekar K, Usha A, Umadevi K, Bafna U. A clinical update on massive ovarian oedema - a pseudotumour? Ecancermedicalscience. 2013;7:318.
Callen AL, Illangasekare T, Poder L. Massive ovarian edema, due to adjacent appendicitis. Emerg Radiol. 2017;24:215–8.
De Cecio R, Cantile M, Fortunato N, De Chiara A, Losito NS, Franco R, Botti G. Massive edema of ovary with cytogenetic alteration of chromosome 12q13-15 in adolescent patient: a case report. J Ovarian Res. 2013;6:13.
Sasaki KJ, Miller CE. Adnexal torsion: review of the literature. J Minim Invasive Gynecol. 2014;21:196–202.
Childress KJ, Dietrich JE. Pediatric ovarian torsion. Surg Clin North Am. 2017;97:209–21.
Asfour V, Varma R, Menon P. Clinical risk factors for ovarian torsion. J Obstet Gynaecol. 2015;35:721–5.
Spinelli C, Piscioneri J, Strambi S. Adnexal torsion in adolescents. Curr Opin Obstet Gynecol. 2015;27:320–5.
González-Bosquet E. Ovarian vein thrombosis. Risk factors, diagnosis and treatment. Medicina (B Aires). 2009;69:347–9.
Kominiarek MA, Hibbard JU. Postpartum ovarian vein thrombosis: an update. Obstet Gynecol Surv. 2006;61:337–42.
Payne JF, Robboy SJ, Haney AF. Embolic microspheres within ovarian arterial vasculature after uterine artery embolization. Obstet Gynecol. 2002;100:883–6.
Young RH, Scully RE. Fibromatosis and massive edema of the ovary, possibly related entities: a report of 14 cases of fibromatosis and 11 cases of massive edema. Int J Gynecol Pathol. 1984;3:153–78.
Lee S, Illei PB, Han JS, Epstein JI. Florid mesothelial hyperplasia of the tunica vaginalis mimicking malignant mesothelioma. Am J Surg Pathol. 2014;38:54–9.
Clement PB, Young RH. Florid mesothelial hyperplasia associated with ovarian tumors: a potential source of error in tumor diagnosis and staging. Int J Gynecol Pathol. 1993;12:51–8.
McCluggage WG, Young RH. Non-neoplastic granulosa cells within ovarian vascular channels: a rare potential diagnostic pitfall. J Clin Pathol. 2004;57:151–4.
Vydianath B, Ganesan R, McCluggage WG. Displaced granulosa cells in the fallopian tube mimicking small cell carcinoma. J Clin Pathol. 2008;61:1323–5.
Duncan DL, Rambally BS, Lininger RA, DiFurio MJ. Displaced granulosa cells in the fallopian tube mistaken for metastatic granulosa cell tumor. Int J Gynecol Pathol. 2013;32:35–7.
Kho RM, Abrao MS. Ovarian remnant syndrome. Curr Opin Obstet Gynecol. 2012;24:210–4.
Magtibay PM, Magrina JF. Ovarian remnant syndrome. Clin Obstet Gynecol. 2006;49:526–34.
Pai SA, Desai SB, Borges AM. Uteruslike masses of the ovary associated with breast cancer and raised serum CA 125. Am J Surg Pathol. 1998;22:333–7.
Takeda A, Imoto S, Mori M, Yamada J, Nakamura H. Uterus-like mass of ovarian ligament: image diagnosis and management by laparoendoscopic single-site surgery. J Obstet Gynaecol Res. 2011;37:1895–9.
Pueblitz-Peredo S, Luévano-Flores E, Rincón-Taracena R, Ochoa-Carrillo FJ. Uterus like mass of the ovary: endomyometriosis or congenital malformation? A case with a discussion of histogenesis. Arch Pathol Lab Med. 1985;109:361–4.
Shutter J. Uterus-like ovarian mass presenting near menarche. Int J Gynecol Pathol. 2005;24:382–4.
Fukunaga M. Smooth muscle metaplasia in ovarian endometriosis. Histopathology. 2000;36:348–52.
Zurkova M, Turkova M, Tichy T, Pilka R, Kolek V, Kriegova E. Sarcoidosis of female reproductive organs in a postmenopausal woman. Menopause. 2015;22:549–53.
Parveen A, Elliott H, Howells R. Sarcoidosis of the ovary. J Obstet Gynaecol (Lahore). 2004;24:465.
Gawron I, Chmura L, Adamek D, Skotniczny K, Pityński K, Ludwin A. Laparoscopic intervention in acute Crohn’s disease involving an ovary. J Minim Invasive Gynecol. 2017;24:1040–5.
Pereira R, de Carvalho J, de Medeiros A, Silva C, Capelozzi V, Bonfá E. Ovarian necrotizing vasculitis in a patient with lupus. Lupus. 2009;18:1313–5.
Bell DA, Mondschein M, Scully RE. Giant cell arteritis of the female genital tract. A report of three cases. Am J Surg Pathol. 1986;10:696–701.
Dincsoy HP, Rolfes DB, McGraw CA, Schubert WK. Cholesterol ester storage disease and mesenteric lipodystrophy. Am J Clin Pathol. 1984;81:263–9.
Mount SL, Eltabbakh GH, Hardin NJ. Beta-2 microglobulin amyloidosis presenting as bilateral ovarian masses: a case report and review of the literature. Am J Surg Pathol. 2002;26:130–3.
McCluggage WG, Allen DC. Ovarian granulomas: a report of 32 cases. J Clin Pathol. 1997;50:324–7.
Clement PB, Young RH, Scully RE. Necrotic pseudoxanthomatous nodules of ovary and peritoneum in endometriosis. Am J Surg Pathol. 1988;12:390–7.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Science Press & Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Suster, D., Liu, M.Z., Lin, D.I. (2019). Benign Diseases of the Ovary. In: Zheng, W., Fadare, O., Quick, C., Shen, D., Guo, D. (eds) Gynecologic and Obstetric Pathology, Volume 2. Springer, Singapore. https://doi.org/10.1007/978-981-13-3019-3_3
Download citation
DOI: https://doi.org/10.1007/978-981-13-3019-3_3
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-3018-6
Online ISBN: 978-981-13-3019-3
eBook Packages: MedicineMedicine (R0)