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Premalignant Conditions of the Oral Cavity pp 27–66Cite as

Oral Carcinogenesis and Malignant Transformation

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Part of the book series: Head and Neck Cancer Clinics ((HNCC))

Abstract

Cancer of the oral cavity and oropharynx is a significant health burden, with over 300,000 new cases diagnosed annually [1]. Oral squamous cell carcinoma (OSCC) constitutes 95% of these malignancies and is mostly preceded by lesions termed oral potentially malignant disorders (OPMDs) that have a high tendency for malignant transformation [2]. Despite advances in diagnosis and treatment modalities, the survival rate of OSCC has not changed significantly in the last five decades [3]. The poor prognosis of oral cancer can largely be attributed to its frequent diagnosis at an advanced stage [4]. Understanding the process and natural history of oral carcinogenesis has the capacity to improve the clinical outcomes of patients with OSCC through early detection and effective OPMD management. This chapter discusses the most recent concepts and knowledge on oral carcinogenesis and malignant transformation of OPMDs.

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  1. Australian Centre for Oral Oncology Research and Education, UWA Dental School, University of Western Australia, Perth, WA, Australia

    Camile S. Farah, Kate Shearston, Amanda Phoon Nguyen & Omar Kujan

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  1. Camile S. Farah
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Correspondence to Camile S. Farah .

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  1. Department of Oral and Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK

    Peter A. Brennan

  2. Department of Oral and Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK

    Tom Aldridge

  3. Department of Otolaryngology, Head Neck Surgery, Queen Elizabeth University Hospital, Glasgow, UK

    Raghav C. Dwivedi

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Farah, C.S., Shearston, K., Nguyen, A.P., Kujan, O. (2019). Oral Carcinogenesis and Malignant Transformation. In: Brennan, P., Aldridge, T., Dwivedi, R. (eds) Premalignant Conditions of the Oral Cavity. Head and Neck Cancer Clinics. Springer, Singapore. https://doi.org/10.1007/978-981-13-2931-9_3

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