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Premalignant Conditions of the Oral Cavity pp 229–276Cite as

Management of Premalignant Disease of the Oral Mucosa

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Part of the book series: Head and Neck Cancer Clinics ((HNCC))

Abstract

Oral potentially malignant disorders (OPMDs) have been defined as ‘a morphologically altered tissue in which cancer is more likely to occur than in its apparently normal counterpart’ [1, 2]. A number of lesions and conditions are included under the umbrella of OPMD including (1) leukoplakia, (2) erythroplakia, (3) oral submucous fibrosis, (4) palatal lesions in reverse smokers, (5) oral lichen planus, (6) discoid lupus erythematosus and (7) actinic cheilitis [3]. In addition, rare inherited conditions, such as xeroderma pigmentosum and Fanconi’s anaemia, carry an increased incidence of oral cancer. Immunodeficiency due to the prolonged use of immunosuppressive drugs or due to an underlying HIV infection may increase risk, and oral cancer has also been reported in patients suffering from chronic graft versus host disease (GVHD) after haematopoietic stem cell transplantation. A risk assessment tool for head and neck cancer is shown in Fig. 11.1.

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  1. Australian Centre for Oral Oncology Research and Education, UWA Dental School, University of Western Australia, Perth, WA, Australia

    Camile S. Farah, Katherine Pollaers & Agnieszka Frydrych

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  1. Camile S. Farah
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  2. Katherine Pollaers
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Correspondence to Camile S. Farah .

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  1. Department of Oral and Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK

    Peter A. Brennan

  2. Department of Oral and Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK

    Tom Aldridge

  3. Department of Otolaryngology, Head Neck Surgery, Queen Elizabeth University Hospital, Glasgow, UK

    Raghav C. Dwivedi

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Farah, C.S., Pollaers, K., Frydrych, A. (2019). Management of Premalignant Disease of the Oral Mucosa. In: Brennan, P., Aldridge, T., Dwivedi, R. (eds) Premalignant Conditions of the Oral Cavity. Head and Neck Cancer Clinics. Springer, Singapore. https://doi.org/10.1007/978-981-13-2931-9_11

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