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Clinical Application of the Forced Oscillation Technique (FOT)

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Advances in Asthma

Abstract

The forced oscillation technique (FOT) is a noninvasive method for measurement of respiratory system resistance (Rrs) and reactance (Xrs) during tidal breathing, which avoids the requirement for forced expiration (as in spirometry). Its clinical application has progressed worldwide with the spread of commercially available broadband frequency FOT devices, including MostGraph and impulse oscillometry (IOS). An increasing number of reports have demonstrated the usefulness of FOT in the management of asthma and COPD. Rrs, especially Rrs at 5 Hz (R5), is a marker of airway caliber, i.e., airway narrowing. Since the changes in FOT parameters are generally greater than the changes in spirometry, the FOT may be useful in airway reversibility testing to diagnose asthma. By using both Rrs and Xrs, it is possible to differentiate asthma from COPD, particularly when combined with the characteristic colored 3D images produced by MostGraph. The FOT is not a surrogate test for spirometry but should be used complementarily. Furthermore, there is a need to establish reference values and provide interpretations of measured data.

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References

  1. Oostveen E, Macleod D, Lorino H, Farré R, Hantos Z, Desager K, et al. The forced oscillation technique in clinical practice: methodology, recommendations and future developments. Eur Respir J. 2003;22:1026–41.

    Article  CAS  PubMed  Google Scholar 

  2. Shirai T, Kurosawa H. Clinical application of the forced oscillation technique. Intern Med. 2016;55(6):559–66. https://doi.org/10.2169/internalmedicine.55.5876.

    Article  PubMed  Google Scholar 

  3. Ichinose M, Sugiura H, Nagase H, Yamaguchi M, Inoue H, Sagara H, Tamaoki J, Tohda Y, Munakata M, Yamauchi K, Ohta K, Japanese Society of Allergology. Japanese guidelines for adult asthma 2017. Allergol Int. 2017;66:163–89. https://doi.org/10.1016/j.alit.2016.12.005.

    Article  PubMed  Google Scholar 

  4. Mori K, Shirai T, Mikamo M, Shishido Y, Akita T, Morita S, et al. Colored 3-dimensional analyses of respiratory resistance and reactance in COPD and asthma. COPD. 2011;8:456–63. https://doi.org/10.3109/15412555.2011.626818.

    Article  PubMed  Google Scholar 

  5. Shirai T, Mori K, Mikamo M, Shishido Y, Akita T, Morita S, et al. Respiratory mechanics and peripheral airway inflammation and dysfunction in asthma. Clin Exp Allergy. 2013;43:521–6. https://doi.org/10.1016/j.anai.2012.02.007.

    Article  CAS  PubMed  Google Scholar 

  6. Shi Y, Aledia AS, Galant SP, George SC. Peripheral airway impairment measured by oscillometry predicts loss of asthma control in children. J Allergy Clin Immunol. 2013;131:718–23. https://doi.org/10.1016/j.jaci.2012.09.022.

    Article  PubMed  Google Scholar 

  7. Bickel S, Popler J, Lesnick B, Eid N. Impulse oscillometry. Interpretation and practical applications. Chest. 2014;146:841–7. https://doi.org/10.1378/chest.13-1875.

    Article  PubMed  Google Scholar 

  8. Murakami K, Habukawa C, Kurosawa H, Takemura T. Evaluation of airway responsiveness using colored three-dimensional analyses of a new forced oscillation technique in controlled asthmatic and nonasthmatic children. Respir Investig. 2014;52:57–64. https://doi.org/10.1016/j.resinv.2013.07.003.

    Article  PubMed  Google Scholar 

  9. Shirai T, Mori K, Tsuchiya T, Suda T. Resonant frequency as a predictor of phase 3 slope of nitrogen single-breath washout in asthma. Ann Allergy Asthma Immunol. 2015;115:73–4. https://doi.org/10.1016/j.anai.2015.05.003.

    Article  PubMed  Google Scholar 

  10. Shirai T, Mori K, Mikamo M, Shishido Y, Akita T, Morita S, et al. Usefulness of colored 3D imaging of respiratory impedance in asthma. Allergy, Asthma Immunol Res. 2013;5:322–8. https://doi.org/10.4168/aair.2013.5.5.322.

    Article  Google Scholar 

  11. Tanimura K, Hirai T, Sato S, Hasegawa K, Muro S, Kurosawa H, et al. Comparison of two devices for respiratory impedance measurement using a forced oscillation technique: basic study using phantom models. J Physiol Sci. 2014;64:377–82. https://doi.org/10.1007/s12576-014-0329-4.

    Article  CAS  PubMed  Google Scholar 

  12. Abe Y, Shibata Y, Igarashi A, Inoue S, Sato K, Sato M, et al. Reference values of MostGraph measures for middle-aged and elderly Japanese individuals who participated in annual health checkups. Respir Investig. 2016;54:148–55. https://doi.org/10.1016/j.resinv.2015.12.004.

    Article  PubMed  Google Scholar 

  13. Shiota S, Katoh M, Fujii M, Aoki S, Matsuoka R, Fukuchi Y. Predictive equations and the reliability of the impulse oscillatory system in Japanese adult subjects. Respirology. 2005;10:310–5.

    Article  PubMed  Google Scholar 

  14. Antonelli A, Crimi E, Gobbi A, Torchio R, Gulotta C, Dellaca R, et al. Mechanical correlates of dyspnea in bronchial asthma. Physiol Rep. 2013;1:e00166. https://doi.org/10.1002/phy2.166.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Takeda T, Oga T, Niimi A, Matsumoto H, Ito I, Yamaguchi M, et al. Relationship between small airway function and health status, dyspnea and disease control in asthma. Respiration. 2010;80:120–6. https://doi.org/10.1159/000242113.

    Article  PubMed  Google Scholar 

  16. Watanabe H, Tanaka Y, Endo Y, Suzuki T, Noguchi R, Saigusa M, et al. Usefulness of the forced oscillation technique in the management of cough variant asthma. The 66th Annual Meeting of Japanese Society of Allergology. 2017, Tokyo.

    Google Scholar 

  17. Gulotta C, Suki B, Brusasco V, Pellegrino R, Gobbi A, Pedotti A, et al. Monitoring the temporal changes of respiratory resistance: a novel test for the management of asthma. Am J Respir Crit Care Med. 2012;185:1330–1.

    Article  PubMed  PubMed Central  Google Scholar 

  18. American Thoracic Society. Standardization of spirometry, 1994 update. Am J Respir Crit Care Med. 1995;152:1107–36.

    Article  Google Scholar 

  19. Beydon N, Davis SD, Lombardi E, Allen JL, Arets HG, Aurora P, et al. An official American Thoracic Society/European Respiratory Society statement: pulmonary function testing in preschool children. Am J Respir Crit Care Med. 2007;175:1304–45.

    Article  PubMed  Google Scholar 

  20. Akamatsu T, Shirai T, Shimoda Y, Suzuki T, Hayashi I, Noguchi R, et al. Forced oscillation technique as a predictor of FEV1 improvement in asthma. Respir Physiol Neurobiol. 2017;236:78–83. https://doi.org/10.1016/j.resp.2016.11.013.

    Article  PubMed  Google Scholar 

  21. Niimi A, Matsumoto H, Takemura M, Ueda T, Chin K, Mishima M. Relationship of airway wall thickness to airway sensitivity and airway reactivity in asthma. Am J Respir Crit Care Med. 2003;168:983–8.

    Article  PubMed  Google Scholar 

  22. Fukuhara M, Tsuburai T, Nakamura Y, Tomita Y, Hamada Y, Watai K, et al. The fraction of exhaled nitric oxide (FeNO) and forced oscillation technique (FOT) can predict bronchial hyperresponsiveness against acetylcholine in treated asthmatics. Arerugi. 2017;66:42–9. https://doi.org/10.15036/arerugi.66.42.

    Article  PubMed  Google Scholar 

  23. Akamatsu T, Tanaka Y, Watanabe H, Endo Y, Shimoda Y, Suzuki T, et al. Forced oscillation technique as a predictor of airway hyperresponsiveness in asthma. The Congress of European Respiratory Society. 2016, London.

    Google Scholar 

  24. Boudewijin IM, Telenga ED, van der Wiel E, van der Molen T, Schiphof L, Ten Hacken NH, et al. Less small airway dysfunction in asymptomatic bronchial hyperresponsiveness than in asthma. Allergy. 2013;68:1419–26. https://doi.org/10.1111/all.12242.

    Article  CAS  Google Scholar 

  25. Matsumoto H, Niimi A, Jinnai M, Nakaji H, Takeda T, Oguma T, et al. Association of alveolar nitric oxide levels with pulmonary function and its reversibility in stable asthma. Respiration. 2011;81:311–7. https://doi.org/10.1159/000319566.

    Article  CAS  PubMed  Google Scholar 

  26. Williamson PA, Clearie K, Menzies D, Vaidyanathan S, Lipworth BJ. Assessment of small-airways disease using alveolar nitric oxide and impulse oscillometry in asthma and COPD. Lung. 2011;189:121–9. https://doi.org/10.1007/s00408-010-9275-y.

    Article  PubMed  Google Scholar 

  27. Ioan I, Marchal F, Coffinet L, Coutier L, Bonabel C, Demoulin B, et al. Breathing-related changes of respiratory resistance in vocal cord dysfunction. Respirology. 2016;21:1134–6. https://doi.org/10.1111/resp.12735.

    Article  PubMed  Google Scholar 

  28. Shimizu Y, Kamiyoshihara M, Okajo J, Ishii Y, Takise A. Tracheobronchial stenosis evaluated by inspiratory and expiratory three-dimensional computed tomography and impulse oscillation with three-dimensional color imaging in a patient with relapsing polychondritis. J Biol Regul Homeost Agents. 2014;28:325–31.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan

    Toshihiro Shirai

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Correspondence to Toshihiro Shirai .

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Editors and Affiliations

  1. Department of Hematology and Respiratory Medicine, Kochi Medical School, Nankoku-shi, Kochi, Japan

    Akihito Yokoyama

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Shirai, T. (2019). Clinical Application of the Forced Oscillation Technique (FOT). In: Yokoyama, A. (eds) Advances in Asthma. Respiratory Disease Series: Diagnostic Tools and Disease Managements. Springer, Singapore. https://doi.org/10.1007/978-981-13-2790-2_8

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  • DOI: https://doi.org/10.1007/978-981-13-2790-2_8

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