Skip to main content

Prolonged Intermittent Renal Replacement Therapy in Pediatric AKI

  • Chapter
  • First Online:
  • 1347 Accesses

Abstract

Acute kidney injury in children in intensive care is often secondary to shock and multi-organ dysfunction syndrome. These children are often on inotropes, are hypotensive, and are fluid overloaded. Continuous renal replacement therapy (CRRT) often used in developed world requires expertise, expensive machinery, consumables, trained staff and is labor intensive. Sustained low-efficiency dialysis (SLED) refers to intermittent renal replacement therapy over an extended period of time. There is now evidence in favor of this therapy especially in adults, with few case series from pediatric literature.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Sethi SK, Sinha R, Jha P, Wadhwani N, Raghunathan V, Dhaliwal M, Bansal SB, Kher V, Lobo V, Sharma J, Raina R. Feasibility of sustained low efficiency dialysis in critically sick pediatric patients: a multicentric retrospective study. Hemodial Int. 2017. https://doi.org/10.1111/hdi.12605.

    Article  Google Scholar 

  2. Sinha R, Sethi SK, Bunchman T, Lobo V, Raina R. Prolonged intermittent renal replacement therapy in children. Pediatr Nephrol. 2017. https://doi.org/10.1007/s00467-017-3732-2.

    Article  Google Scholar 

  3. Raina R, Chauvin AM, Bunchman T, Askenazi D, Deep A, Ensley MJ, Krishnappa V, Sethi SK. Treatment of AKI in developing and developed countries: an international survey of pediatric dialysis modalities. PLoS One. 2017;12(5):e0178233. https://doi.org/10.1371/journal.pone.0178233.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Zhang L, Yang J, Eastwood GM, Zhu G, Tanaka A, Bellomo R. Extended daily dialysis versus continuous renal replacement therapy for acute kidney injury: a meta-analysis. Am J Kidney Dis. 2015;66(2):322–30.

    Article  Google Scholar 

  5. Lee CY, Yeh HC, Lin CY. Treatment of critically ill children with kidney injury by sustained low-efficiency daily diafiltration. Pediatr Nephrol. 2012;27(12):2301–9. https://doi.org/10.1007/s00467-012-2254-1.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Sethi SK, Bansal SB, Khare A, Dhaliwal M, Raghunathan V, Wadhwani N, Nandwani A, Yadav DK, Mahapatra AK, Raina R. Heparin free dialysis in critically sick children using sustained low efficiency dialysis (SLEDD-f): a new hybrid therapy for dialysis in developing world. PLoS One. 2018;13(4):e0195536.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Sethi, S.K. (2019). Prolonged Intermittent Renal Replacement Therapy in Pediatric AKI. In: Sethi, S., Raina, R., McCulloch, M., Bunchman, T. (eds) Critical Care Pediatric Nephrology and Dialysis: A Practical Handbook. Springer, Singapore. https://doi.org/10.1007/978-981-13-2276-1_10

Download citation

  • DOI: https://doi.org/10.1007/978-981-13-2276-1_10

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-2275-4

  • Online ISBN: 978-981-13-2276-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics