Abstract
By integrating the experimental information given from the Hybrid/ Integrative methods to determine the structures of large macromolecular machines, the static and dynamic molecular models in the atomic or semi-atomic resolution have been built with the aid of bioinformatics and computer simulations. Here, review of the recent progresses of such computational methods are made with discussion for the future direction.
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Acknowledgements
This work was supported by grants from the Database Integration Coordination Program from the National Bioscience Database Center (NBDC) – JST (Japan Science and Technology Agency), the Platform Project for Supporting in Drug Discovery and Life Science Research (Platform for Drug Discovery, Informatics, and Structural Life Science) from AMED, and JSPS KAKENHI [17K07364].
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Nakamura, H. (2018). Overall Introduction and Rationale, with View from Computational Biology. In: Nakamura, H., Kleywegt, G., Burley, S., Markley, J. (eds) Integrative Structural Biology with Hybrid Methods. Advances in Experimental Medicine and Biology, vol 1105. Springer, Singapore. https://doi.org/10.1007/978-981-13-2200-6_1
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DOI: https://doi.org/10.1007/978-981-13-2200-6_1
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