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Trans-lamina Cribrosa Pressure Difference Activates Mechanical Stress Signal Transduction to Induce Glaucomatous Optic Neuropathy: A Hypothesis

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Intraocular and Intracranial Pressure Gradient in Glaucoma

Part of the book series: Advances in Visual Science and Eye Diseases ((AVSED,volume 1))

Abstract

Glaucoma is the leading cause of irreversible blindness in the world. According to a recent meta-analysis, the global prevalence of glaucoma has reached 3.54%, and the number of people with glaucoma worldwide would increase to 110 million in 2040. Glaucoma, as one of the most common eye conditions resulting in blindness, has been recognized as a major public health challenge [1].

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Authors and Affiliations

  1. Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China

    Jingxue Zhang, Shen Wu & Ningli Wang

  2. Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China

    Jingxue Zhang, Shen Wu & Ningli Wang

Authors
  1. Jingxue Zhang
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  2. Shen Wu
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  3. Ningli Wang
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Correspondence to Ningli Wang .

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Editors and Affiliations

  1. Beijing Tongren Hospital, Capital Medical University, Beijing, China

    Ningli Wang

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Zhang, J., Wu, S., Wang, N. (2019). Trans-lamina Cribrosa Pressure Difference Activates Mechanical Stress Signal Transduction to Induce Glaucomatous Optic Neuropathy: A Hypothesis. In: Wang, N. (eds) Intraocular and Intracranial Pressure Gradient in Glaucoma. Advances in Visual Science and Eye Diseases, vol 1. Springer, Singapore. https://doi.org/10.1007/978-981-13-2137-5_24

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  • DOI: https://doi.org/10.1007/978-981-13-2137-5_24

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-2136-8

  • Online ISBN: 978-981-13-2137-5

  • eBook Packages: MedicineMedicine (R0)

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