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Outlook on Therapeutic Strategies for Primary Open-Angle Glaucoma Based on the Theory of Translamina-Pressure Difference

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Intraocular and Intracranial Pressure Gradient in Glaucoma

Part of the book series: Advances in Visual Science and Eye Diseases ((AVSED,volume 1))

Abstract

Glaucoma is a group of optic nerve lesions characterized by progressive loss of retinal ganglion cells (RGCs) and their axons and primarily manifested by progressive optic nerve damage, atrophy, and visual field defects, with increased intraocular pressure (IOP) being the main risk factor [1]. Generally, glaucoma is classified into two types: primary angle-closure glaucoma (PACG) and primary open-angle glaucoma (POAG). PACG is mainly a result of optic nerve damage caused by blockage of aqueous humor outflow and elevated intraocular pressure due to mechanical angle closure, and its pathogenesis has been clearly known. Along with the economic development and lifestyle changes in the country, the disease profiles have changed greatly. Currently, primary open-angle glaucoma (POAG) has become the most common irreversible eye disease that results in blindness and disability, accounting for 74% of the patients with glaucoma, with its pathogenesis yet remaining unknown so far [2].

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References

  1. Kwon YH, Fingert JH, Kuehn MH, Alward WL. Primary open-angle glaucoma. N Engl J Med. 2009;360(11):1113–24.

    Article  CAS  Google Scholar 

  2. Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006;90(3):262–7.

    Article  CAS  Google Scholar 

  3. Shields MB. Normal-tension glaucoma: is it different from primary open-angle glaucoma? Curr Opin Ophthalmol. 2008;19(2):85–8.

    Article  Google Scholar 

  4. Wang N, Xie X, Yang D, Xian J, Li Y, Ren R, Peng X, Jonas JB, Weinreb RN. Orbital cerebrospinal fluid space in glaucoma: the Beijing intracranial and intraocular pressure (iCOP) study. Ophthalmology. 2012;119(10):2065–73. e2061

    Article  Google Scholar 

  5. Burgoyne CF, Downs JC. Premise and prediction-how optic nerve head biomechanics underlies the susceptibility and clinical behavior of the aged optic nerve head. J Glaucoma. 2008;17(4):318–28.

    Article  Google Scholar 

  6. Fechtner RD, Weinreb RN. Mechanisms of optic nerve damage in primary open angle glaucoma. Surv Ophthalmol. 1994;39(1):23–42.

    Article  CAS  Google Scholar 

  7. Yamamoto T, Kitazawa Y. Vascular pathogenesis of normal-tension glaucoma: a possible pathogenetic factor, other than intraocular pressure, of glaucomatous optic neuropathy. Prog Retin Eye Res. 1998;17(1):127–43.

    Article  CAS  Google Scholar 

  8. Band LR, Hall CL, Richardson G, Jensen OE, Siggers JH, Foss AJ. Intracellular flow in optic nerve axons: a mechanism for cell death in glaucoma. Invest Ophthalmol Vis Sci. 2009;50(8):3750–8.

    Article  Google Scholar 

  9. Zhang Z, Wang X, Jonas JB, Wang H, Zhang X, Peng X, Ritch R, Tian G, Yang D, Li L, et al. Valsalva manoeuver, intra-ocular pressure, cerebrospinal fluid pressure, optic disc topography: Beijing intracranial and intra-ocular pressure study. Acta Ophthalmol. 2013;

    Google Scholar 

  10. Sakka SG. The patient with intra-abdominal hypertension. Anasthesiol Intensivmed Notfallmed Schmerzther. 2016;51(1):8–16.

    Article  Google Scholar 

  11. Youssef AM, Hamidian Jahromi A, Vijay CG, Granger DN, Alexander JS. Intra-abdominal hypertension causes reversible blood-brain barrier disruption. J Trauma Acute Care Surg. 2012;72(1):183–8.

    CAS  PubMed  Google Scholar 

  12. Sinclair AJ, Walker EA, Burdon MA, van Beek AP, Kema IP, Hughes BA, Murray PI, Nightingale PG, Stewart PM, Rauz S, Tomlinson JW. Cerebrospinal fluid corticosteroid levels and cortisol metabolism in patients with idiopathic intracranial hypertension: a link between 11beta-HSD1 and intracranial pressure regulation? J Clin Endocrinol Metab. 2010;95(12):5348–56.

    Article  CAS  Google Scholar 

  13. Jacobson DM, Wall IM, Digre KB, Corbett J. Serum vitamin A concentrate is elevated in idiopathic intracranial hypertension. Neurology. 1999;53:1114–8.

    Article  CAS  Google Scholar 

  14. Warner JEA, Bernstein PS, Yemelyanov A, Alder SC, Farnsworth ST, Digre KB. Vitamin A in the cerebrospinal fluid of patients with and without idiopathic intracranial hypertension. Ann Neurol. 2002;52:647–50.

    Article  CAS  Google Scholar 

  15. Selhorst J, Kulkantrakorn K, Corbett JJ, Leira EC, Chung SM. Retinol- binding protein in idiopathic intracranial hypertension (IIH). J Neuroophthalmol. 2000;20:250–2.

    Article  CAS  Google Scholar 

  16. Wang YX, Jonas JB, Wang N, You QS, Yang D, Xie XB, Xu L. Intraocular pressure and estimated cerebrospinal fluid pressure. The Beijing Eye Study 2011. PLoS One. 2014;9(8):e104267.

    Article  Google Scholar 

  17. Xu L, Wang YX, Wang S, Jonas JB. Neuroretinal rim area and body mass index. PLoS One. 2012;7(1):e30104.

    Article  CAS  Google Scholar 

  18. Ren R, Wang N, Zhang X, Tian G, Jonas JB. Cerebrospinal fluid pressure correlated with body mass index. Graefes Arch Clin Exp Ophthalmol. 2012;250(3):445–6.

    Article  Google Scholar 

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Authors and Affiliations

  1. Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China

    Weiwei Chen & Ningli Wang

  2. Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China

    Weiwei Chen & Ningli Wang

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  1. Weiwei Chen
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  2. Ningli Wang
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Correspondence to Ningli Wang .

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Editors and Affiliations

  1. Beijing Tongren Hospital, Capital Medical University, Beijing, China

    Ningli Wang

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Chen, W., Wang, N. (2019). Outlook on Therapeutic Strategies for Primary Open-Angle Glaucoma Based on the Theory of Translamina-Pressure Difference. In: Wang, N. (eds) Intraocular and Intracranial Pressure Gradient in Glaucoma. Advances in Visual Science and Eye Diseases, vol 1. Springer, Singapore. https://doi.org/10.1007/978-981-13-2137-5_18

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  • DOI: https://doi.org/10.1007/978-981-13-2137-5_18

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-2136-8

  • Online ISBN: 978-981-13-2137-5

  • eBook Packages: MedicineMedicine (R0)

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