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Knowing the Neuronal Mechanism of Spontaneous Pain to Treat Chronic Pain in the Future

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Advances in Pain Research: Mechanisms and Modulation of Chronic Pain

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1099))

Abstract

Spontaneous pain is the major complain for the patients to see a doctor. Human imaging studies presented that spontaneous pain is mainly associated with activity changes in medial pain pathway, while broader brain regions were activated by allodynia pain. On behavioral level, temporally disassociation between the evoked pain and spontaneous pain was observed; these data gave a hint that the spontaneous pain and evoked pain may be mediated by different neuronal mechanisms. And more attentions should be paid to the spontaneous pain to treat the chronic pain in the future.

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Acknowledgments

This study was supported by the National Program on Key Basic Research Project (973 Program) (2014CB548200) and Chinese National Natural Science Foundation (81571068).

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Authors and Affiliations

  1. Institute of Neuroscience, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

    Xiang-Yao Li, Jing-Hua Wang & Cheng Wu

Authors
  1. Xiang-Yao Li
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  2. Jing-Hua Wang
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  3. Cheng Wu
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Correspondence to Xiang-Yao Li .

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Editors and Affiliations

  1. Division of Neuroscience, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

    Bai-Chuang Shyu

  2. Division of Cell Signaling, Okazaki Institute for Integrative Bioscience (National Institute for Physiological Sciences), Okazaki, Aichi, Japan

    Makoto Tominaga

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Li, XY., Wang, JH., Wu, C. (2018). Knowing the Neuronal Mechanism of Spontaneous Pain to Treat Chronic Pain in the Future. In: Shyu, BC., Tominaga, M. (eds) Advances in Pain Research: Mechanisms and Modulation of Chronic Pain. Advances in Experimental Medicine and Biology, vol 1099. Springer, Singapore. https://doi.org/10.1007/978-981-13-1756-9_10

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