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Role of Phytochemicals in Eliciting Longevity Genes

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Molecular Basis and Emerging Strategies for Anti-aging Interventions

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Abstract

Phytochemicals are diverse secondary metabolites derived from plants, and it has been proven that phytochemicals can extend longevity by evolutionarily conserved mechanisms. The positive impact of dietary phytochemicals on overall health and longevity has been studied extensively over the past decade. The emerging role of phytochemicals as an effector of metabolic and longevity signals offers new therapeutic perspectives. In this regard, we will discuss the role of phytochemicals in eliciting the longevity genes and also the various mechanisms involved. This review will give a broad outline of how different phytochemicals modulate signaling pathways that modulate the expression of specific set of genes. This review will also highlight the most exciting perspective for research in the future in this rapidly developing field of signaling pathways which include the genes encoding heat shock protein, genes responsible for the antioxidant response, genes involved in metabolism, etc. and are crucial for the phytochemicals to elicit longevity.

Despite various beneficial biological functions, phytochemicals might have adverse side effects like carcinogenicity and genotoxicity at high doses or concentrations. Hence, the future research challenge is to determine the optimal dose range and to perform intervention studies in order to improve longevity.

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Authors and Affiliations

  1. Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India

    Kalaiselvi Periandavan & Prema Velusamy

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  1. Kalaiselvi Periandavan
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  2. Prema Velusamy
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Editors and Affiliations

  1. Department of Biochemistry, University of Allahabad, Allahabad, Uttar Pradesh, India

    Syed Ibrahim Rizvi

  2. Medical Biochemistry, Istanbul University, Cerrahpasa, Istanbul, Turkey

    Ufuk Çakatay

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Periandavan, K., Velusamy, P. (2018). Role of Phytochemicals in Eliciting Longevity Genes. In: Rizvi, S., Çakatay, U. (eds) Molecular Basis and Emerging Strategies for Anti-aging Interventions. Springer, Singapore. https://doi.org/10.1007/978-981-13-1699-9_17

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