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Genetic Fingerprinting for Human Diseases: Applications and Implications

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DNA Fingerprinting: Advancements and Future Endeavors

Abstract

DNA fingerprinting traditionally refers to the identification of individuals from blood and/or tissue samples for forensic purposes. But genetic fingerprinting can also include characterization of the genetic basis of human diseases, especially the inherited disorders. Some of the variants or haplotypes identified may run in families and thereby also have pathological or phenotypic connotations. The DNA sequencing technologies have evolved over the years, and nowadays, high-throughput techniques and applications are available with increased automation. Thus, genetic fingerprinting can have various connotations in relation to human diseases. The genetic testing done would depend on the clinical situation or phenotype, and what we are looking for in a specific patient or individual. Pretest and posttest counseling are important to facilitate decision-making.

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Acknowledgments

Thanks to all families whose clinical details have been discussed as cases in this write up. Appropriate consent was taken for publication as per ethical guidelines from parents/guardian. Also, thanks to the individuals/labs for the molecular testing in the patients.

Author information

Authors and Affiliations

  1. Genetic and Metabolic Unit, Department of Pediatrics, Advanced Pediatric Centre (APC), Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

    Inusha Panigrahi

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  1. Inusha Panigrahi
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Editor information

Editors and Affiliations

  1. DNA Fingerprinting Unit, State Forensic Science Laboratory, Sagar, Madhya Pradesh, India

    Hirak Ranjan Dash

  2. DNA Fingerprinting Unit, State Forensic Science Laboratory, Sagar, Madhya Pradesh, India

    Pankaj Shrivastava

  3. Department of Biology and DNA Fingerprinting Unit, Central Forensic Science Laboratory, New Delhi, Delhi, India

    Braja Kishore Mohapatra

  4. Department of Life Science, National Institute of Technology, Rourkela, Odisha, India

    Surajit Das

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Panigrahi, I. (2018). Genetic Fingerprinting for Human Diseases: Applications and Implications. In: Dash, H., Shrivastava, P., Mohapatra, B., Das, S. (eds) DNA Fingerprinting: Advancements and Future Endeavors. Springer, Singapore. https://doi.org/10.1007/978-981-13-1583-1_8

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