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EGFR and FGFR in Growth and Metastasis of Colorectal Cancer

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Role of Tyrosine Kinases in Gastrointestinal Malignancies

Abstract

Colorectal cancer (CRC) is the most important cause of tumor-related fatalities around the world, and its distant metastasis is responsible for 40% of mortalities in the USA as well as around the world. CRC is not a single disease; it is rather an assortment of multiple cancers. Metastatic CRC develops from the relapse period after the therapy, where the cancer cells develop resistance. Due to the heterogeneous biology, clear descriptive study at molecular level about the mechanisms, which takes place during CRC invasion and proliferation, is necessary. These studies can help understand the factors affecting the increased risk of CRC progression and help deduce novel therapeutic strategies. This chapter includes the mechanism of EGFR and FGFR in CRC, which are common targets for therapy since they induce cell proliferation and cell division and inhibit apoptosis. Their overexpression in CRC is associated with metastasis including invasion and angiogenesis.

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Authors and Affiliations

  1. Department of Biosciences and Biotechnology, Banasthali University, Banasthali, Rajasthan, India

    Begum Dariya & Afroz Alam

  2. Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA

    Neha Merchant

  3. Department of Biotechnology, Jawaharlal Nehru Technical University, Hyderabad, Telangana, India

    Sheik Aliya

  4. Department of Hematology and Medical Oncology, School of Medicine, Winship Cancer Institute, Emory University, Atlanta, GA, USA

    Ganji Purnachandra Nagaraju

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Dariya, B., Merchant, N., Aliya, S., Alam, A., Nagaraju, G.P. (2018). EGFR and FGFR in Growth and Metastasis of Colorectal Cancer. In: Nagaraju, G. (eds) Role of Tyrosine Kinases in Gastrointestinal Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-13-1486-5_11

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