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Critical Role of Mitochondrial Autophagy in Cerebral Stroke

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Advancement in the Pathophysiology of Cerebral Stroke

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Abstract

Mitochondria supply energy to cells by generating ATP; thus it can be considered as one of the essential organelles of the cell. For the efficient working of cells, a good quality of mitochondria is essential; thus the elimination of injured or nonfunctional mitochondria by means of mitophagy is a very important process for cell function. Mitophagy showed a neuroprotective property in cerebral ischemia by accurate labeling and entrapment of defective mitochondria into isolation membranes. Then the entrapped mitochondria were digested by lysosomes. Therefore, the regulation of mitophagy in ischemic brain injury may be used as a therapeutic strategy to protect the neuron by the efficient removal of injured mitochondria.

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Author information

Authors and Affiliations

  1. Neurotherapeutics Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, Uttar Pradesh, India

    Pankaj Paliwal & Sairam Krishnamurthy

  2. School of Biomedical Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi, Uttar Pradesh, India

    Gaurav Kumar & Ranjana Patnaik

Authors
  1. Pankaj Paliwal
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  2. Sairam Krishnamurthy
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  3. Gaurav Kumar
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  4. Ranjana Patnaik
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Corresponding author

Correspondence to Pankaj Paliwal .

Editor information

Editors and Affiliations

  1. School of Biomedical Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi, Uttar Pradesh, India

    Ranjana Patnaik

  2. School of Biomedical Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi, Uttar Pradesh, India

    Amit Kumar Tripathi

  3. Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India

    Ashish Dwivedi

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Paliwal, P., Krishnamurthy, S., Kumar, G., Patnaik, R. (2019). Critical Role of Mitochondrial Autophagy in Cerebral Stroke. In: Patnaik, R., Tripathi, A., Dwivedi, A. (eds) Advancement in the Pathophysiology of Cerebral Stroke. Springer, Singapore. https://doi.org/10.1007/978-981-13-1453-7_6

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