Abstract
Aluminum is a type of ubiquitously existing naturally and widely used metal in our world. It is combined with other elements and forms different compounds. In different pH and due to other conditions, it can be released into ions of different valence states. Our century is an “aluminum age”; aluminum is used in many fields of our daily life, such as vaccine adjuvant, antacids, food additives, skin care products, cosmetics, and cooking wares, and may be as elements or contaminants appeared in a lot of foods, including infant formulae, milk products, juice, wine, sea foods, and tea. It also appears in drinking water due to the water treatment process, or naturally coming from weathering rocks and soils, or released from rocks and soils caused by pollution-induced acid rain. Due to good physical and chemical property, aluminum is being tremendously utilized in many industries. In a lot of production and process procedures, aluminum particulates are seriously exposed by workers. Many factors, such as silicon, citrate, iron, calcium, fluoride, etc., can affect absorption of aluminum in human body. Human being ingests aluminum through the respiratory and digestive system and skin. Aluminum can affect our health, especially impair central nervous system. The important damage is cognitive impairment in Al-exposed peoples, Alzheimer’s disease and other neurodegenerative disorders have been related with aluminum exposure, and aluminum has been proposed as etiology.
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Al-Ashmawy MA (2011) Prevalence and public health significance of aluminum residues in milk and some dairy products. J Food Sci 76(3):T73–T76
Amieva H, Le Goff M, Millet X, Orgogozo JM, Pérès K, Barberger-Gateau P, Jacqmin-Gadda H, Dartigues JF (2008) Prodromal Alzheimer’s disease: successive emergence of the clinical symptoms. Ann Neurol 64(5):492–498
Arnich N, Sirot V, Rivière G, Jean J, Noël L, Guérin T, Leblanc JC (2012) Dietary exposure to trace elements and health risk assessment in the 2nd French total diet study. Food Chem Toxicol 50(7):2432–2449
ATSDR (Agency for Toxic Substances and Disease Registry) (1999) A toxicological profile for aluminum. U.S. Department of Health and Human Services, Public Health Service, Atlanta
Barberger-Gateau P, Chaslerie A, Dartigues JF, Commenges D, Gagnon M, Salamon R (1992) Health measures correlates in a French elderly community population: the PAQUID study. J Gerontol 47(2):S88–S95
Barberger-Gateau P, Fabrigoule C, Helmer C, Rouch I, Dartigues JF (1999) Functional impairment in instrumental activities of daily living: an early clinical sign of dementia? J Am Geriatr Soc 47(4):456–462
Bellés M, Sánchez DJ, Gómez M, Corbella J, Domingo JL (1998) Silicon reduces aluminum accumulation in rats: relevance to the aluminum hypothesis of Alzheimer disease. Alzheimer Dis Assoc Disord 12(2):83–87
Bergomi M, Vinceti M, Nacci G, Pietrini V, Brätter P, Alber D, Ferrari A, Vescovi L, Guidetti D, Sola P, Malagu S, Aramini C, Vivoli G (2002) Environmental exposure to trace elements and risk of amyotrophic lateral sclerosis: a population-based case-control study. Environ Res 89(2):116–123
Bishop NJ, Morley R, Day JP, Lucas A (1997) Aluminum neurotoxicity in preterm infants receiving intravenous-feeding solutions. N Engl J Med 336(22):1557–1561
Braganca VL, Melnikov P, Zanoni LZ (2011) Trace elements in fruit juices. Biol Trace Elem Res 146:256–261
Brusewitz S et al (1984) USIP-84-11, Aluminium. Stockholm Univ. Inst. Theor. Phys., Stockholm, 138p
Cao H, Qiao L, Zhang H, Chen J (2010) Exposure and risk assessment for aluminium and heavy metals in Puerh tea. Sci Total Environ 408(14):2777–2784
Carney J, McAdams P, McCluskey J, Roggli VL (2016) Aluminum-induced pneumoconiosis confirmed by analytical scanning electron microscopy: a case report and review of the literature. Ultrastruct Pathol 40(3):155–158
Dabeka R, Fouquet A, Belisle S, Turcotte S (2011) Lead, cadmium and aluminum in Canadian infant formulae, oral electrolytes and glucose solutions. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 28(6):744–753
Dartigues JF, Gagnon M, Letenneur L, Barberger-Gateau P, Commenges D, Evaldre M, Salamon R (1992) Principal lifetime occupation and cognitive impairment in a French elderly cohort (Paquid). Am J Epidemiol 135(9):981–988
Divine KK, Lewis JL, Grant PG, Bench G (1999) Quantitative particle-induced X-ray emission imaging of rat olfactory epithelium applied to the permeability of rat epithelium to inhaled aluminum. Chem Res Toxicol 12(7):575–581
Dockery DW, Pope CA 3rd, Xu X, Spengler JD, Ware JH, Fay ME, Ferris BG Jr, Speizer FE (1993) An association between air pollution and mortality in six US cities. N Engl J Med 329(24):1753–1759
Englert N (2004) Fine particles and human health – a review of epidemiological studies. Toxicol Lett 149(1–3):235–242. Review
Eng PJ, Trainor TP, Brown GE Jr, Waychunas GA, Newville M, Sutton SR, Rivers ML (2000) Structure of the hydrated alpha-Al(2)O(3) (0001) surface. Science 288(5468):1029–1033
Ferreira PC, Piai Kde A, Takayanagui AM, Segura-Muñoz SI (2008) Aluminum as a risk factor for Alzheimer’s disease. Rev Lat Am Enfermagem 16(1):151–157
Flaten TP (2001) Aluminium as a risk factor in Alzheimer's disease, with emphasis on drinking water. Brain Res Bull 55(2):187–196. Review
Flaten TP (1990) Geographical associations between aluminium in drinking water and death rates with dementia (including Alzheimer’s disease), Parkinson’s disease and amyotrophic lateral sclerosis in Norway. Environ Geochem Health 12:152–167
Forbes WF, Agwani N (1994) A suggested mechanism for aluminum biotoxicity. J Theor Biol 171(2):207–214
Forbes WF, Gentleman JF, Maxwell CJ (1995) Concerning the role of aluminum in causing dementia. Exp Gerontol 30(1):23–32
Forbes WF, Hayward LM, Agwani N (1992) Aluminum and Alzheimer’s disease. CMAJ 146(9):1534
Forbes WF, Hayward LM, Agwani N (1991) Dementia, aluminium, and fluoride. Lancet 338(8782–8783):1592–1593
Forbes WF, Hill GB (1998) Is exposure to aluminum a risk factor for the development of Alzheimer disease? Yes. Arch Neurol 55(5):740–741
Forbes WF, McLachlan DR (1996) Further thoughts on the aluminum-Alzheimer’s disease link. J Epidemiol Community Health 50(4):401–403
Forster DP, Newens AJ, Kay DW, Edwardson JA (1995) Risk factors in clinically diagnosed presenile dementia of the Alzheimer type: a case-control study in northern England. J Epidemiol Community Health 49(3):253–258
Frankowski M, Zioła-Frankowska A, Kurzyca I, Novotný K, Vaculovič T, Kanický V, Siepak M, Siepak J (2011) Determination of aluminium in groundwater samples by GF-AAS, ICP-AES, ICP-MS and modelling of inorganic aluminium complexes. Environ Monit Assess 182(1–4):71–84
Frecker MF (1991) Dementia in Newfoundland: identification of a geographical isolate? J Epidemiol Community Health 45(4):307–311
French P, Gardner MJ, Gunn AM (1989) Dietary aluminium and Alzheimer’s disease. Food Chem Toxicol 27(7):495–498
Fulton B, Jaw S, Jeffery EH (1989) Bioavailability of aluminum from drinking water. Fundam Appl Toxicol 12(1):144–150
Garruto RM, Fukatsu R, Yanagihara R, Gajdusek DC, Hook G, Fiori CE (1984) Imaging of calcium and aluminum in neurofibrillary tangle-bearing neurons in parkinsonism-dementia of Guam. Proc Natl Acad Sci U S A 81(6):1875–1879
Gauthier E, Fortier I, Courchesne F, Pepin P, Mortimer J, Gauvreau D (2000) Aluminum forms in drinking water and risk of Alzheimer’s disease. Environ Res 84(3):234–246
Glynn AW, Sparén A, Danielsson LG, Sundström B, Jorhem L (2001) The influence of complexing agents on the solubility and absorption of aluminium in rats exposed to aluminium in water. Food Addit Contam 18(6):515–523
Graves AB, White E, Koepsell TD, Reifler BV, van Belle G, Larson EB (1990) The association between aluminum-containing products and Alzheimer’s disease. J Clin Epidemiol 43(1):35–44
Guerin T, Chekri R, Vastel C, Sirot V, Volatier J-L, Leblanc J-C, Noel L (2011) Determination of 20 trace elements in fish and other seafood from the French market. Food Chem 127:934–942
Harris WR (1992) Equilibrium model for speciation of aluminum in serum. Clin Chem 38:1809–1818
He SC, Qiao N, Sheng W (2003) Neurobehavioral, autonomic nervous function and lymphocyte subsets among aluminum electrolytic workers. Int J Immunopathol Pharmacol 16(2):139–144
Health Canada (2010) Aluminum chloride, aluminum nitrate, aluminum sulfate. Priority Substances List Assessment Report. Follow-up to the State of Science Report 2000. Environment Canada, Ottawa. Available at: http://www.ec.gc.ca/CEPARegistry/documents/subs_list/Aluminium_Salts/final/Al_salts__toc.cfm
Hoflich BL, Weinbruch S, Theissmann R, Gorzawski H, Ebert M, Ortner HM, Skogstad A, Ellingsen DG, Drablos PA, Thomassen Y (2005) Characterization of individual aerosol particles in workroom air of aluminium smelter potrooms. J Environ Monit 7(5):419–424
Ilyin A, Gromov A, An F, Faubert V, de Izarra C, Espagnscq A, Brunet L (2002) Characterization of aluminum powders I. Influence of renal impairment, chemical form, and serum protein binding on intravenous and oral aluminum kinetics in the rabbit. Toxicol Appl Pharmacol 1988 95(1):32–43
IPCS (International Programme on Chemical Safety) (1997) Aluminum. Environmental health criteria 194. World Health Organization, Geneva
Jinzhu Y, Qinli Z, Jin Y, Pan K, Jianjun H, Qiao N (2015) Aluminum and benzo[a]pyrene co-operate to induce neuronal apoptosis in vitro. J Toxicol Sci 40(3):365–373
Kihira T, Yoshida S, Mitani K, Yasui M, Yase Y (1993) ALS in the Kii peninsula of Japan, with special reference to neurofibrillary tangles and aluminum. Neuropathology 13(2):125–136
Kihira T, Kanno S, Miwa H, Okamoto K, Kondo T (2007) The role of exogenous risk factors in amyotrophic lateral sclerosis in Wakayama. Jpn Amyotroph Lateral Scler 8(3):150–156
Kongerud J, Søyseth V (2014) Respiratory disorders in aluminum smelter workers. J Occup Environ Med 56(5 Suppl):S60–S70
Krewski D, Yokel RA, Nieboer E, Borchelt D, Cohen J, Harry J, Kacew S, Lindsay J, Mahfouz AM, Rondeau V (2007) Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide. J Toxicol Environ Health B Crit Rev 10(Suppl 1):1–269
Li G, Zhao X, Wu S, Hua H, Wang Q, Zhang Z (2017) Dietary exposure to aluminium in the popular Chinese fried bread youtiao. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 11:1–8
Liya Ge, Jianghong Jiang, Xiaoyan Wu (2009) Investigation on aluminum content in Youtiao in Wuhan. Spectr Instrum Anal Z1:61–64
L’vov BV, Polzik LK, Weinbruch S, Ellingsen DG, Thomassen Y (2005) Theoretical aspects of fluoride air contaminant formation in aluminium smelter potrooms. J Environ Monit 7(5):425–430
Lu X, Liang R, Jia Z, Wang H, Pan B, Zhang Q, Niu Q (2014) Cognitive disorders and tau-protein expression among retired aluminum smelting workers. J Occup Environ Med 56(2):155–160
Maitani T, Kubota H, Hori N, Yoshihira K, Takeda M (1994) Distribution and urinary excretion of aluminium injected with several organic acids into mice: relationship with chemical state in serum studied by the HPLC-ICP method. J Appl Toxicol 14(4):257–261
Maltseva A, Serra C, Kogevinas M (2016) Cancer risk among workers of a secondary aluminium smelter. Occup Med (Lond) 66(5):412–414
Markesbery WR, Ehmann WD, Alauddin M, Hossain TI (1984) Brain trace element concentrations in aging. Neurobiol Aging 5(1):19–28
Martyn CN, Coggon DN, Inskip H, Lacey RF, Young WF (1997) Aluminum concentrations in drinking water and risk of Alzheimer’s disease. Epidemiology 8(3):281–286
Martyn CN, Barker DJ, Osmond C, Harris EC, Edwardson JA, Lacey RF (1989) Geographical relation between Alzheimer’s disease and aluminum in drinking water. Lancet 1(8629):59–62
McLachlan DR, Bergeron C, Smith JE, Boomer D, Rifat SL (1996) Risk for neuropathologically confirmed Alzheimer’s disease and residual aluminum in municipal drinking water employing weighted residential histories. Neurology 46(2):401–405
Millour S, Noel L, Kadar A, Chekri R, Vastel CH, Sirot V et al (2011) Pb, Hg, Cd, As, Sb and Al levels in foodstuffs from the 2nd French total diet study. Food Chem 126:1787–1799
Mizumoto Y, Iwata S, Sasajima K, Yoshida S, Yoshimasu F, Yase Y (1983) Determination of the Ca/P atomic ratio in the spinal cord of patients with amyotrophic lateral sclerosis by neutron activation and X-ray fluorescence analysis. Radioisotopes 32(11):551–554. Japanese
Mussi I, Calzaferri G, Buratti M, Alessio L (1984) Behaviour of plasma and urinary aluminium levels in occupationally exposed subjects. Int Arch Occup Environ Health 54:155–161
Nancy Chuchu, Bhavini Patel, Blaise Sebastian, Christopher Exley (2013) The aluminium content of infant formulas remains too high. BMC Pediatr 13:162–166
Neri LC, Hewitt D (1991) Aluminium, Alzheimer’s disease, and drinking water. Lancet 338(8763):390
Nieboer E, Thomassen Y, Chashchin V, Odland JØ (2005) Occupational exposure assessment of metals. J Environ Monit 7(5):412–415. Review
Nolte E, Beck E, Winklhofer C, Steinhausen C (2001) Compartmental model for aluminium biokinetics. Hum Exp Toxicol 20(2):111–117
Polizzi S, Pira E, Ferrara M, Bugiani M, Papaleo A, Albera R, Palmi S (2002) Neurotoxic effects of aluminium among foundry workers and Alzheimer’s disease. Neurotoxicology 23(6):761–774
Ohno K, Ishikawa K, Kurosawa Y, Matsui Y, Matsushita T, Magara Y (2010) Exposure assessment of metal intakes from drinking water relative to those from total diet in Japan. Water Sci Technol 62:2694–2701
Ondreicka R, Ginter E, Kortus J (1967) Effect of increased doses of aluminum salts on the metabolism of experimental animals. Cesk Gastroenterol Vyz 21(1):40–51
Perl DP, Gajdusek DC, Garruto RM, Yanagihara RT, Gibbs CJ (1982) Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and Parkinsonism-dementia of Guam. Science 217(4564):1053–1055
Perl DP, Pendlebury WW (1986) Aluminum neurotoxicity – potential role in the pathogenesis of neurofibrillary tangle formation. Can J Neurol Sci 13(4 Suppl):441–445
Piccardo P, Yanagihara R, Garruto RM, Gibbs CJ Jr, Gajdusek DC (1988) Histochemical and X-ray microanalytical localization of aluminum in amyotrophic lateral sclerosis and parkinsonism-dementia of Guam. Acta Neuropathol 77(1):1–4
Powell JJ, Greenfield SM, Parkes HG, Nicholson JK, Thompson RP (1993) Gastro-intestinal availability of aluminium from tea. Food Chem Toxicol 31(6):449–454
Powell JJ, Thompson RP (1993) The chemistry of aluminium in the gastrointestinal lumen and its uptake and absorption. Proc Nutr Soc 52(1):241–253
Zhang QL, Li MQ, Ji JW, Gao FP, Bai R, Chen CY, Wang ZW, Zhang C, Niu Q (2011) In vivo toxicity of nano-alumina on mice neurobehavioral profiles and the potential mechanisms. Int J Immunopathol Pharmacol 24(1S):23–29
Ramírez-Altamirano Mde J, Fenton-Navarro P, Sivet-Chiñas E, Harp-Iturribarria Fde M, Martínez-Cruz R, Cruz PH, Cruz MM, Pérez-Campos E (2012) The relationship of aluminium and silver to neural tube defects; a case control. Iran J Pediatr 22(3):369–374
Rajasekaran K (2000) Effects of combined exposure to aluminium, ethanol on food intake, motor behaviour, a few biochemical parameters in pubertal rats. Environ Toxicol Pharmacol 9:25–30
Rossbach B, Buchta M, Csanády GA, Filser JG, Hilla W, Windorfer K, Stork J, Zschiesche W, Gefeller O, Pfahlberg A, Schaller KH, Egerer E, Escobar Pinzón LC, Letzel S (2006) Biological monitoring of welders exposed to aluminium. Toxicol Lett 162(2–3):239–245
Santibáñez M, Bolumar F, García AM (2007) Occupational risk factors in Alzheimer’s disease: a review assessing the quality of published epidemiological studies. Occup Environ Med 64(11):723–732
Sauvel C, Barberger-Gateau P, Dequae L, Letenneur L, Dartigues JF (1994) Factors associated with a 1-year development in the functional autonomy of elderly persons living at home. Rev Epidemiol Sante Publique 42(1):13–23. French
Shimizu H, Mori T, Koyama M, Sekiya M, Ooami H (1994) A correlative study of the aluminum content and aging changes of the brain in non-demented elderly subjects. Nihon Ronen Igakkai Zasshi 31(12):950–960. Japanese
Sjögren B, Lundberg I, Lidums V (1983) Aluminium in the blood and urine of industrially exposed workers. Br J Ind Med 40:301–304
Stahl T, Taschan H, Brunn H (2011) Aluminium content of selected foods and food products. Environ Sci Eur 23:37–48
Stitch SR (1957) Trace elements in human tissue. 1. A semi-quantitative spectrographic survey. Biochem J 67(1):97–103
Tariba B (2011) Metals in wine-impact on wine quality and health outcomes. Biol Trace Elem Res 144:143–156
Taneda M (1984) Effect of aluminum on rat brain. Enhancement by calcium deficiency. Hokkaido Igaky Zasshi 59(3):312–337
The Health and Population Planing Commission of China (2014, December 24) National Standard for Food Safety-food additives utilization standard
Thomassen Y, Koch W, Dunkhorst W, Ellingsen DG, Skaugset NP, Jordbekken L, Arne Drabløs P, Weinbruch S (2006) Ultrafine particles at workplaces of a primary aluminium smelter. J Environ Monit 8(1):127–133
Traub RD, Rains TC, Garruto RM, Gajdusek DC, Gibbs CJ Jr (1981) Brain destruction alone does not elevate brain aluminum. Neurology 31(8):986–990
Van der Voet GB, de Wolff FA (1987a) Intestinal absorption of aluminium in rats: effect of sodium. Arch Toxicol Suppl 11:231–235
Van der Voet GB, De Wolff FA (1987b) The effect of di- and trivalent iron on the intestinal absorption of aluminum in rats. Toxicol Appl Pharmacol 90(2):190–197
Virk SA, Eslick GD (2015) Occupational exposure to aluminum and Alzheimer disease: a meta-analysis. J Occup Environ Med 57(8):893–896
Wagner W (1999) Canadian minerals yearbook. Natural Resources Canada, Ottawa
Walton J, Hams G, Wilcox D (1994) Bioavailability of Aluminium from drinking water: co-exposure with foods and beverages, Research Report No. 83. Urban Water Research Association of Australia, Melbourne Water Corporation, Melbourne
Wang W, Yang H, Wang X, Jiang J, Zhu W (2010) Effects of fulvic acid and humic acid on aluminum speciation in drinking water. J Environ Sci (China) 22(2):211–217
Weidenhamer JD, Fitzpatrick MP, Biro AM, Kobunski PA, Hudson MR, Corbin RW, Gottesfeld P (2017) Metal exposures from aluminum cookware: an unrecognized public health risk in developing countries. Sci Total Environ 579:805–813
Weinbruch S, Benker N, Koch W, Ebert M, Drablos PA, Skaugset NP et al (2010) Hygroscopic properties of the workroom aerosol in aluminium smelter potrooms: a case for transport of HF and SO2 into the lower airways. J Environ Monit 12:448–454
Westberg HB, Seldén AI, Bellander T (2001) Exposure to chemical agents in Swedish aluminum foundries and aluminum remelting plants – a comprehensive survey. Appl Occup Environ Hyg 16(1):66–77
Wettstein A, Aeppli J, Gautschi K, Peters M (1991) Failure to find a relationship between mnestic skills of octogenarians and aluminum in drinking water. Int Arch Occup Environ Health 63(2):97–103
Wood DJ, Cooper C, Stevens J, Edwardson J (1988) Bone mass and dementia in hip fracture patients from areas with different aluminium concentrations in water supplies. Age Ageing 17(6):415–419
Yase Y, Matsumoto N, Azuma K, Nakai Y, Shiraki H (1972) Amyotrophic lateral sclerosis. Association with schizophrenic symptoms and showing Alzheimer’s tangles. Arch Neurol 27(2):118–128
Yasui M, Ota K (1992) Experimental and clinical studies on dysregulation of magnesium metabolism and the aetiopathogenesis of multiple sclerosis. Magnes Res 5(4):295–302
Yasui M, Yase Y, Ota K, Garruto RM (1991a) Aluminum deposition in the central nervous system of patients with amyotrophic lateral sclerosis from the Kii Peninsula of Japan. Neurotoxicology 12(3):615–620
Yasui M, Yase Y, Ota K, Mukoyama M, Adachi K (1991b) High aluminum deposition in the central nervous system of patients with amyotrophic lateral sclerosis from the Kii Peninsula, Japan: two case reports. Neurotoxicology 12(2):277–283
Yasui M, Ota K, Yoshida M (1997) Effects of low calcium and magnesium dietary intake on the central nervous system tissues of rats and calcium-magnesium related disorders in the amyotrophic lateral sclerosis focus in the Kii Peninsula of Japan. Magnes Res 10(1):39–50
Yokel RA (2013) Aluminum. In: Cabello A (ed) Encyclopedia of human nutrition, vol 1, 3rd edn. Academic, Waltham, pp 57–56
Yokel RA, McNamara PJ (1985) Aluminum bioavailability and disposition in adult and immature rabbits. Toxicol Appl Pharmacol 77(2):344–352
Yokel RA, McNamara PJ (1988) Influence of renal impairment, chemical form, and serum protein binding on intravenous and oral aluminum kinetics in the rabbit. Toxicol Appl Pharmacol 98(1):32–43
Yokel RA Ei-Samragy Y (2012) Aluminum in food-the nature and contribution of food additives. In Tech:203–228. Available at http://www.intechopen.com/articles/show/title/aluminum-in-food-the-nature-and-contributionof-food-additives
Yoshida S, Yoshimasu F, Yase Y, Kawai K, Iwata S (1980) Metal analysis in CNS tissue of ALS case – related to the high content of heavy metals in his drinking water (author’s transl). Rinsho Shinkeigaku 20(1):16–24
Yoshimasu F, Uebayashi Y, Yase Y, Iwata S, Sasajima K (1976) Studies on amyotrophic lateral sclerosis by neutron activation analysis. Folia Psychiatr Neurol Jpn 30(1):49–55
Yoshimasu F, Yasui M, Yase Y, Iwata S, Gajdusek DC, Gibbs CJ Jr, Chen KM (1980) Studies on amyotrophic lateral sclerosis by neutron activation analysis – 2. Comparative study of analytical results on Guam PD, Japanese ALS and Alzheimer disease cases. Folia Psychiatr Neurol Jpn 34(1):75–82
Yoshimasu F, Yasui M, Yoshida H, Yoshida S, Yase Y (1985) Metal studies on Alzheimer disease by neutron activation analysis. Rinsho Shinkeigaku 25(6):738–743. [Article in Japanese]
Zapatero MD, Garcia de Jalon A, Pascual F, Calvo ML, Escanero J, Marro A (1995) Serum aluminum levels in Alzheimer’s disease and other senile dementias. Biol Trace Elem Res 47(1–3):235–240
Zhang JL, Liu GY (2007) Main resources of aluminum ingested by human body. Chin J Health Lab Technol 17(11):1934–1936
Zhang Q, Wang H, Ge C, Duncan J, He K, Adeosun SO, Xi H, Peng H, Niu Q (2017) Alumina at 50 and 13 nm nanoparticle sizes have potential genotoxicity. J Appl Toxicol 37(9):1053–1064
Zhang Q, Xu L, Wang J, Sabbioni E, Piao L, Di Gioacchino M, Niu Q (2013) Lysosomes involved in the cellular toxicity of nano-alumina: combined effects of particle size and chemical composition. J Biol Regul Homeost Agents 27(2):365–375
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Niu, Q. (2018). Overview of the Relationship Between Aluminum Exposure and Health of Human Being. In: Niu, Q. (eds) Neurotoxicity of Aluminum. Advances in Experimental Medicine and Biology, vol 1091. Springer, Singapore. https://doi.org/10.1007/978-981-13-1370-7_1
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