Abstract
The quorum sensing (QS) is a well-characterized phenomenon in the microbial world for cellular communication and being exploited for intraspecies, interspecies and even interkingdom interactions. This robust and widely distributed social networking cascade assists the microbes to emerge as strong parasites for the hosts. Moreover, the colonization with more efficient cross talk among the microbes further intensifies their infections. Here, we will be focusing to decipher the evolutionary status of the QS regulators (LuxI and LuxR) in the prokaryotic world. LuxI is a signal synthase, while LuxR is the recipient for sensing internal (cognate LuxR/solos LuxR) and external (solos LuxR) signals. These regulators are reported to evolve vertically as well as borrowed through horizontal gene transfer w.r.t. ecological niche. Their universal distribution in the microbial world further corroborates the need for targeting multiple signaling system regulators.
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Atkinson S, Williams P (2009) Quorum sensing and social networking in the microbial world. J R Soc Interface 6:959–978. https://doi.org/10.1098/rsif.2009.0203
Biswa P, Doble M (2013) Production of acylated homoserine lactone by gram-positive bacteria isolated from marine water. FEMS Microbiol Lett 343:34–41. https://doi.org/10.1111/1574-6968.12123
Bose U, Ortori CA, Sarmad S, Barrett DA, Hewavitharana AK, Hodson MP, Fuerst JA, Shaw PN, Boden R (2017) Production of N-acyl homoserine lactones by the sponge-associated marine actinobacteria Salinispora arenicola and Salinispora pacifica. FEMS Microbiol Lett 364. https://doi.org/10.1093/femsle/fnx002
Churchill ME, Sibhatu HM, Uhlson CL (2011) Defining the structure and function of acyl-homoserine lactone autoinducers. Methods Mol Biol 692:159–171. https://doi.org/10.1007/978-1-60761-971-0_12
Cude WN, Buchan A (2013) Acyl-homoserine lactone-based quorum sensing in the Roseobacter clade: complex cell-to-cell communication controls multiple physiologies. Front Microbiol 4:336. https://doi.org/10.3389/fmicb.2013.00336
Dubern JF, Diggle SP (2008) Quorum sensing by 2-alkyl-4-quinolones in Pseudomonas aeruginosa and other bacterial species. Mol BioSyst 4:882–888. https://doi.org/10.1039/b803796p
Gupta AK, Kaur K, Rajput A, Dhanda SK, Sehgal M, Khan MS, Monga I, Dar SA, Singh S, Nagpal G, Usmani SS, Thakur A, Kaur G, Sharma S, Bhardwaj A, Qureshi A, Raghava GP, Kumar M (2016) ZikaVR: an integrated Zika virus resource for genomics, proteomics, phylogenetic and therapeutic analysis. Sci Rep 6:32713. https://doi.org/10.1038/srep32713
Hudaiberdiev S, Choudhary KS, Vera Alvarez R, Gelencser Z, Ligeti B, Lamba D, Pongor S (2015) Census of solo LuxR genes in prokaryotic genomes. Front Cell Infect Microbiol 5:20. https://doi.org/10.3389/fcimb.2015.00020
Jangid K, Kong R, Patole MS, Shouche YS (2007) luxRI homologs are universally present in the genus Aeromonas. BMC Microbiol 7:93. https://doi.org/10.1186/1471-2180-7-93
Kalia VC, Purohit HJ (2011) Quenching the quorum sensing system: potential antibacterial drug targets. Crit Rev Microbiol 37:121–140. https://doi.org/10.3109/1040841x.2010.532479
Kalia VC, Wood TK, Kumar P (2014) Evolution of resistance to quorum-sensing inhibitors. Microb Ecol 68:13–23. https://doi.org/10.1007/s00248-013-0316-y
Kroger C, Kary SC, Schauer K, Cameron AD (2016) Genetic regulation of virulence and antibiotic resistance in Acinetobacter baumannii. Genes (Basel) 8:93. https://doi.org/10.3390/genes8010012
Parsek MR, Greenberg EP (2000) Acyl-homoserine lactone quorum sensing in gram-negative bacteria: a signaling mechanism involved in associations with higher organisms. Proc Natl Acad Sci U S A 97:8789–8793. https://doi.org/10.1073/pnas.97.16.8789
Patankar AV, Gonzalez JE (2009) Orphan LuxR regulators of quorum sensing. FEMS Microbiol Rev 33:739–756. https://doi.org/10.1111/j.1574-6976.2009.00163.x
Pennisi E (2008) Evolution. Building the tree of life, genome by genome. Science 320:1716–1717. https://doi.org/10.1126/science.320.5884.1716
Polkade AV, Mantri SS, Patwekar UJ, Jangid K (2016) Quorum sensing: an under-explored phenomenon in the Phylum Actinobacteria. Front Microbiol 7:131. https://doi.org/10.3389/fmicb.2016.00131
Purohit AA, Johansen JA, Hansen H, Leiros HK, Kashulin A, Karlsen C, Smalas A, Haugen P, Willassen NP (2013) Presence of acyl-homoserine lactones in 57 members of the Vibrionaceae family. J Appl Microbiol 115:835–847. https://doi.org/10.1111/jam.12264
Rajput A, Gupta AK, Kumar M (2015) Prediction and analysis of quorum sensing peptides based on sequence features. PLoS One 10:e0120066. https://doi.org/10.1371/journal.pone.0120066
Rajput A, Kaur K, Kumar M (2016) SigMol: repertoire of quorum sensing signaling molecules in prokaryotes. Nucleic Acids Res 44:D634–D639. https://doi.org/10.1093/nar/gkv1076
Rajput A, Kumar M (2017a) Computational exploration of putative LuxR solos in Archaea and their functional implications in quorum sensing. Front Microbiol 8:798. https://doi.org/10.3389/fmicb.2017.00798
Rajput A, Kumar M (2017b) In silico analyses of conservational, functional and phylogenetic distribution of the LuxI and LuxR homologs in Gram-positive bacteria. Sci Rep. https://doi.org/10.1038/s41598-017-07241-5
Rajput A, Thakur A, Sharma S, Kumar M (2018) aBiofilm: a resource of anti-biofilm agents and their potential implications in targeting antibiotic drug resistance. Nucleic Acids Res 46:D894–d900. https://doi.org/10.1093/nar/gkx1157
Rasmussen BB, Nielsen KF, Machado H, Melchiorsen J, Gram L, Sonnenschein EC (2014) Global and phylogenetic distribution of quorum sensing signals, acyl homoserine lactones, in the family of Vibrionaceae. Mar Drugs 12:5527–5546. https://doi.org/10.3390/md12115527
Santos CL, Correia-Neves M, Moradas-Ferreira P, Mendes MV (2012) A walk into the LuxR regulators of Actinobacteria: phylogenomic distribution and functional diversity. PLoS One 7:e46758. https://doi.org/10.1371/journal.pone.0046758
Sharma A, Lal R (2017) Survey of (Meta)genomic approaches for understanding microbial community dynamics. Indian J Microbiol 57:23–38. https://doi.org/10.1007/s12088-016-0629-x
Subramoni S, Florez Salcedo DV, Suarez-Moreno ZR (2015) A bioinformatic survey of distribution, conservation, and probable functions of LuxR solo regulators in bacteria. Front Cell Infect Microbiol 5:16. https://doi.org/10.3389/fcimb.2015.00016
Subramoni S, Venturi V (2009) LuxR-family ‘solos’: bachelor sensors/regulators of signalling molecules. Microbiology 155:1377–1385. https://doi.org/10.1099/mic.0.026849-0
Wynendaele E, Bronselaer A, Nielandt J, D’Hondt M, Stalmans S, Bracke N, Verbeke F, Van De Wiele C, De Tre G, De Spiegeleer B (2013) Quorumpeps database: chemical space, microbial origin and functionality of quorum sensing peptides. Nucleic Acids Res 41:D655–D659. https://doi.org/10.1093/nar/gks1137
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Department of Biotechnology, Government of India (GAP0001) and Council of Scientific and Industrial Research (CSIR) supported this work.
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Kumar, M., Rajput, A. (2018). Phylogenomics and Evolutionary Perspective of Quorum Sensing Regulators (LuxI/LuxR) in Prokaryotes. In: Kalia, V. (eds) Quorum Sensing and its Biotechnological Applications. Springer, Singapore. https://doi.org/10.1007/978-981-13-0848-2_4
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