Abstract
Melissa officinalis L. (Lamiaceae), commonly known as lemon balm, is an important plant of herbal materia medica. The plant is native to Central Asia and South-Central Europe. Now, M. officinalis is widely naturalized in the United States and the rest of the world.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Agata I, Kusakabe H, Hatano T, et al. Melitric acids A and B, new trimeric caffeic acid derivatives from Melissa officinalis. Chem Pharm Bull. 1993;41:1608–11.
Awad R, Levac D, Cybulska P, Merali Z, Trudeau VL, Arnason JT. Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system. Can J Physiol Pharmacol. 2007;85:933–42.
Ballard CG, O’Brien JT, Reichelt K, Perry EK. Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind, placebo-controlled trial with Melissa. J Clin Psychiatry. 2002;63:553–8.
Brieskorn CH, Krause W. Further triterpenes from Melissa officinalis L. Arch Pharm (Weinheim). 1974;307:603–12.
Burns A, Perry E, Holmes C, Francis P, Morris J, Howes MJ, et al. A double-blind placebo-controlled randomised trial of Melissa officinalis oil and donepezil for the treatment of agitation in Alzheimer’s disease. Dement Geriatr Cogn Disord. 2011;31:158–64.
Cases J, Ibarra A, Feuillère N, Roller M, Sukkar S. Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. Mediterr J Nutr Metab. 2011;4:211–8.
Glowatzki G. Melissa, a drug for 2000 years. Med Klin. 1970;17(65):800–3.
Hanganu D, Vlase L, Filip L, Sand C, Mirel S, Indrei LL. The study of some polyphenolic compounds from Melissa officinalis L. (Lamiaceae). Rev Med Chir Soc Med Nat Iasi. 2008;112:525–9.
Hefendehl FW. Composition of etheric oil of Melissa officinalis L. and secondary changes of oil composition. Arch Pharm Ber Dtsch Pharm Ges. 1970;303:345–57.
Kennedy DO, Scholey AB, Tildesley NT, Perry EK, Wesnes KA. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav. 2002;72:953–64.
Kennedy DO, Wake G, Savelev S, et al. Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties. Neuropsychopharmacology. 2003;28:1871–81.
Kennedy DO, Scholey AB, Tildesley NT, Perry EK, Wesnes KA. Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm). Psychosom Med. 2004;66:607–13.
Kennedy DO, Little W, Haskell CF, Scholey AB. Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory induced stress. Phytother Res. 2006;20:96–102.
Kerner D. Paracelusus and Melissa officinalis. Med Welt. 1965;13(11):554–7.
Lin SH, Chou ML, Chen WC, Lai YS, Lu KH, Hao CW, Sheen LY. A medicinal herb, Melissa officinalis L. ameliorates depressive-like behavior of rats in the forced swimming test via regulating the serotonergic neurotransmitter. J Ethnopharmacol. 2015;175:266–72.
Morelli I. Constituents and uses of Melissa officinalis. Boll Chim Farm. 1977;116:334–40.
Mulkens A, Kapetanidis I. Eugenylglucoside, a new natural Phenylpropanoid Heteroside from Melissa officinalis. J Nat Prod. 1988;51:496–8.
Muller SF, Klement S. A combination of valerian and lemon balm is effective in the treatment of restlessness and dyssomnia in children. Phytomedicine. 2006;13:383–7.
Taavoni S, Mazem Ekbatani N, Haghani H. Valerian/lemon balm use for sleep disorders during menopause. Complement Ther Clin Pract. 2013;19:193–6.
Taiwo AE, Leite FB, Lucena GM, Barros M, Silveira D, Silva MV, Ferreira VM. Anxiolytic and antidepressant-like effects of Melissa officinalis (lemon balm) extract in rats: influence of administration and gender. Indian J Pharmacol. 2012;44:189–92.
Thieme H, Kitze C. Occurrence of flavonoids in Melissa officinalis L. Pharmazie. 1973;28:69–70.
Tittel G, Wagner H, Bos R. Chemical composition of the essential oil from Melissa. Planta Med. 1982;46:91–8.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Saroya, A.S., Singh, J. (2018). Neuropharmacology of Melissa officinalis L.. In: Pharmacotherapeutic Potential of Natural Products in Neurological Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-13-0289-3_8
Download citation
DOI: https://doi.org/10.1007/978-981-13-0289-3_8
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-0288-6
Online ISBN: 978-981-13-0289-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)