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Genomic Approach to Asthma pp 179–200Cite as

MicroRNA and Its Application in Asthma Studies

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Part of the book series: Translational Bioinformatics ((TRBIO,volume 12))

Abstract

Asthma is a respiratory disease that is closely associated with genetic and environmental conditions, and miRNA is known as the key regulator of epigenetics. This is a kind of small non-coding RNA, which is involved in the translation process of proteins indirectly, controlling the behavior of the body. Recent studies have found that a large number of asthmatic patients have abnormal miRNA expression, and that miRNA has played a key role in asthma, including in regulating the immune function, airway inflammation, and airway remodeling. Therefore, this article reviews the application of microRNA in asthma.

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Abbreviations

3′-UTR:

3′-untranslated region

AHR:

airway hyperresponsiveness

ASM:

airway smooth muscle

BD:

bronchodilator

BDNF:

brain-derived neurotrophic factor

BALF:

bronchoalveolar lavage fluid

BSM:

bronchial smooth muscle

DEP:

diesel exhaust particles

ELISA:

enzyme-linked immune sorbent assay

EOS:

eosinophilic

FEV1 :

forced expired volume in one second

FVC:

forced vital capacity

GCS:

glucocorticosteroid

GSK-3β:

glycogen synthase kinase-3β

HDM:

house dust mite

HLA-G:

Human Leucocyte Antigen G

IFN-γ:

interferon-γ

IRAK1:

IL-1 receptor associated kinase 1

KLF4:

Krüppel-like factor 4

LPS:

lipopolysaccharide

MAREs:

Maf recognize elements

miRNA:

microRNA

MyD88:

myeloid differentiation factor 88

NE:

neutrophilic

NFκβ:

nuclear factor kappa beta

OVA:

ovalbumin

PBMCs:

peripheral blood mononuclear cells

PCR:

polymerase Chain Reaction

PDCD4:

programmed cell death protein 4

PEF:

peak expiratory flow

PI3K:

phosphatidylinositol 3-hydroxy kinase

PM:

particulate matter

RISC:

RNA-induced silencing complex

RT-PCR:

reverse transcription-polymerase chain reaction

RUNX3:

runt-related transcription factor 3

SHH:

sonic hedgehog

SHIP1:

SH2-containing inositol 1

SOCS1:

suppressor of signaling cytokine1

SPP1:

secreted phosphoprotein 1

stRNA:

small tenporal RNA

T-Bet:

T-box expressed in T cells

TCR:

T cell antigen receptor

TLR4:

Toll-like receptor 4

TRAF6:

TNF receptor associated factor 6

TSLP:

Thymic stromal lymphopoietin

VEGF:

vascular endothelial growth factor

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Author information

Authors and Affiliations

  1. The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China

    Fang Chen, Yan-Jing Qian & Ting-Ting Xia

  2. First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, China

    Jia-Ying Zhang & Fang Wang

Authors
  1. Fang Chen
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  2. Yan-Jing Qian
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  3. Jia-Ying Zhang
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  4. Fang Wang
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Editor information

Editors and Affiliations

  1. Zhongshan Hospital Institute of Clinical Science, Shanghai Medical School Fudan University, Shanghai, China

    Xiangdong Wang

  2. Shanghai Respiratory Research Institute, Respiratory Division of Zhongshan Hospital, Fudan University, Shanghai, China

    Zhihong Chen

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© 2018 Springer Nature Singapore Pte Ltd.

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Chen, F., Qian, YJ., Zhang, JY., Wang, F., Xia, TT. (2018). MicroRNA and Its Application in Asthma Studies. In: Wang, X., Chen, Z. (eds) Genomic Approach to Asthma. Translational Bioinformatics, vol 12. Springer, Singapore. https://doi.org/10.1007/978-981-10-8764-6_9

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