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Anticancer Plants: Clinical Trials and Nanotechnology pp 253–272Cite as

Organosulfur Compounds of Garlic as Potent Chemotherapeutic Agents Against Cancer

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Abstract

Experimental and epidemiological studies over the past few decades have provided ample evidences with regard to the association amid plant food consumption and decreased cancer risk. Many phytochemicals have proved their anticancer potential to be used as therapeutics against cancer. Among them garlic (Allium sativum) has been of much interest, mostly due to the epidemiological reports, which linked the increased garlic consumption with reduced prevalence of many human diseases. Garlic and their constituent organosulfur compounds (OSCs) have been attributed to several medicinal properties like hypocholesterolemic, fibrinolytic, immunostimulatory, antimicrobial, antiviral, antifungal, and anticancer effects. The OSCs have been shown to have strong anticarcinogenic property against a variety of chemical carcinogens in different preclinical animal model studies. Extensive researches are still being carried out to elucidate the molecular mechanism of action of OSCs. The main focus of the present chapter is to give an overview of the past and present studies undergoing on organosulfur compounds for exploring their potential as an adjunct in cancer chemotherapeutics and research.

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Authors and Affiliations

  1. Department of Biosciences, Integral University, Lucknow, Uttar Pradesh, India

    Irfan Ahmad Ansari, Imran Khan & Mohd Salman Khan

  2. Department of Botany, Gandhi Faiz-e-Aam College, Shahjahanpur, Uttar Pradesh, India

    Mohd Sayeed Akhtar

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  1. Irfan Ahmad Ansari
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  2. Imran Khan
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  3. Mohd Salman Khan
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Correspondence to Irfan Ahmad Ansari or Mohd Salman Khan .

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  1. Department of Botany, Gandhi Faiz-e-Aam College, Shahjahanpur, Uttar Pradesh, India

    Mohd Sayeed Akhtar

  2. Department of Crop Science, Faculty of Agriculture, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

    Mallappa Kumara Swamy

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Ansari, I.A., Khan, I., Khan, M.S., Akhtar, M.S. (2017). Organosulfur Compounds of Garlic as Potent Chemotherapeutic Agents Against Cancer. In: Akhtar, M., Swamy, M. (eds) Anticancer Plants: Clinical Trials and Nanotechnology. Springer, Singapore. https://doi.org/10.1007/978-981-10-8216-0_9

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