Abstract
Alkaline phosphatase (ALP) is a membrane-bound enzyme present mainly in the liver, bone, intestine, and placenta. ALP shows maximum activity at about pHÂ 10. This enzyme is intracellular and only a small amount is present in plasma. In certain disease conditions, the breakdown of cell causes release of enzyme to plasma leading to increased enzyme levels in plasma. The ALP of normal serum in adults is mainly derived from the liver and bone and small amount from intestinal component. During childhood the majority of alkaline phosphatase is of skeletal origin. During pregnancy, ALP is also contributed from the placenta. ALP is activated by magnesium ions. The activity in serum is due to isoenzymes from various organs, but the major contribution occurs from the liver.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Kumar, V., Gill, K.D. (2018). To Estimate the Activity of Alkaline Phosphatase in Serum. In: Basic Concepts in Clinical Biochemistry: A Practical Guide. Springer, Singapore. https://doi.org/10.1007/978-981-10-8186-6_26
Download citation
DOI: https://doi.org/10.1007/978-981-10-8186-6_26
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-8185-9
Online ISBN: 978-981-10-8186-6
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)