Abstract
Ayurvedic medicines are often used in different formulations, the heavy metals, which are generally referred to as being toxic. In this work, we report on the physicochemical characterization and biological activity of some typical Ayurvedic drugs available in the market that contain arsenic, mercury and lead with the emphasis on their antibacterial performance. Among the formulations studied, some of the drugs with ‘amorphous’ texture (and higher solubility) were found quite active against some bacterial strains whereas the formulations possessing crystalline texture (and low solubility) were found practically ineffective. The moderate activity of some drugs against Gram-negative bacteria fairly suggested the presence of the small-sized polar molecules which was also supported by the FTIR spectroscopic data.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Kapoor RC (2010) Some observations on the metal-based preparations in Indian systems of medicine. Indian J Tradit Med
Adhikari R (2014) Ayurvedic bhasmas: overview on nanomaterialistic aspects, applications, and perspectives. In: Rameshwar A, Santosh T (eds) Advances in experimental medicine and biology, vol 807. Springer, India, New Delhi, pp 23–32
Governmet of India Department of Indian Systems of Medicine and Homeopahty (2003) The ayurvedic pharmacopoeia of India, 2nd edn. The controller of publications, New Delhi
Jarup L (2003) Hazards of heavy metal contamination. Br Med Bull 68(1):167–182
Saper RB, Kales SN, Paquin J, Burns MJ, Eisenberg DM, Davis RB, Phillips RS, Phillips RS (2004) Heavy metal content of ayurvedic herbal medicine. JAMA J Am Med Assoc 292(23):1–8
Chan K (2003) Some aspects of toxic contaminants in herbal medicines. Chemosphere 52(9):1361–1371
Tchounwou PB, Yedjou CG, Patlolla AK, Sutton DJ (2012). Heavy metal toxicity and the environment, vol 101. Springer, Basel, pp 133–164
Janadri S, Mishra AP, Kumar R, Shanmukh I, Rao N, Kharya M (2015) Preparation and characterization of mercury-based traditional herbomineral formulation: Shwas kuthar rasa. J Ayurveda Integr Med 6(4):268–272
Guillen MD, Cabo N (1997) Infrared spectroscopy in the study of edible oils and fats. J Sci Food Agric 75(111):1–11
Silverstein RM, Webster FX, Kiemle DJ, Bryce DL (2014) Spectrometric identification of organic compounds. Wiley
Cohen GN (2011) The outer membrane of gram-negative bacteria and the cytoplasmic membrane. Springer, Netherlands, pp 11–16
Acknowledgements
We would like to acknowledge Universal Science and Engineering College, Chakopat, Lalitpur for providing lab facility for antimicrobial tests, Antonella Esposito (University of Rouen, France) for FTIR measurements and Dr. Bhanu Bhakta Neupane (Central Department of Chemistry, Tribhuvan University, Kathmandu) for microscopic studies.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Nature Singapore Pte Ltd.
About this paper
Cite this paper
Panta, P., Bhandari, T.R., Lamsal, B., Adhikari, R. (2018). Characterization and Antimicrobial Property of Some Heavy Metals Containing Ayurvedic Drugs. In: Adhikari, R., Thapa, S. (eds) Infectious Diseases and Nanomedicine III. Advances in Experimental Medicine and Biology, vol 1052. Springer, Singapore. https://doi.org/10.1007/978-981-10-7572-8_7
Download citation
DOI: https://doi.org/10.1007/978-981-10-7572-8_7
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-7571-1
Online ISBN: 978-981-10-7572-8
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)