Abstract
For taking care of patients with liver disease, it is important to understand both the liver histology and the liver test data. Liver biopsy is the most reliable way (gold standard) to know the histology, but invasive. It is also well accepted that the peripheral blood flow within the liver parenchyma is easily influenced by histological changes, such as liver fibrosis, necrosis, edema, and collapse. On the other hand, the liver function is regulated by four main factors, uptake, metabolism, secretion of the liver cells, and liver blood flow. Therefore, analyzing the hemodynamics in the peripheral area of the liver parenchyma may become a relevant way for estimating the histology and the function of the liver. Accordingly, we have studied the significance of the arrival-time parametric image and the perfusion parametric image obtained by Sonazoid®-enhanced ultrasound in diagnosing hepatitis C virus-related chronic liver diseases, especially liver cirrhosis.
As a result, we found analyzing the hepatic microcirculation and the portal vein blood flow by contrast-enhanced ultrasound may be of great help for understanding what is happening within the liver parenchyma in patients with liver cirrhosis.
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References
Reuter SR, Redman HC. Gastrointestinal angiography. Philadelphia: WB Sounders; 1977. p. 306–55.
Lautt WW, Legare DJ, D’Almeida MS. Adenosine as putative regulator of hepatic arterial flow (the buffer response). Am J Physiol. 1985;248:H331–8.
Oda M, Kan S, Yokomori H. Regulatory mechanisms of the hepatic microcirculation. In: Miura Y, Itai Y, editors. Macroscopical observation of the hepatic microcirculation and of the characteristic blood flow of the liver tumor. Tokyo: Medical Tribune; 2000. (Japanese).
Miura Y. Regulatory mechanisms of the portal blood flow observed from the point of point of TAE. In: Miura Y, Itai Y, editors. Macroscopical observation of the hepatic microcirculation and of the characteristic blood flow of the liver tumor. Tokyo: Medical Tribune; 2000. (Japanese).
Zhang Q, Yuan ZG, Wang DQ, et al. Perfusion CT findings in liver of patients with tumor during chemotherapy. World J Gastroenterol. 2010;16:3202–5.
Takahashi H, Suzuki M, Ikeda H, et al. Evaluation of quantitative portal venous, hepatic arterial, and total hepatic tissue blood flow using Xenon CT in alcoholic liver cirrhosis comparison with liver cirrhosis C. Alcohol Clin Exp Res. 2007;31:43–8S.
Hashimoto K, Murakami T, Dono K, et al. Assessment of the severity of liver disease and fibrotic change: the usefulness of hepatic CT perfusion imaging. Oncol Rep. 2006;16:677–83.
Moreno AH, Rousselot LM, Panke WF, et al. The rate of hepatic blood flow in normal subjects and in patients with portal hypertension. Surg Gynecol Obstet. 1960;111:443–50.
Sarpar R, Fajman WA, Rypins EB, et al. A noninvasive method for measuring portal venous-total hepatic blood flow by hepato-splenic radio-nuclide angiography. Radiology. 1989;141:179–84.
Shimada K. Clinical evaluation of the hepatic hemodynamics using 99mTc-DTPA-HAS scintiangiography in patients with viral chronic liver disease. Kanzo. 1994;35:11–8. (Japanese).
Sumino Y, Wakui N, Takayama R, et al. Ultrasonographic diagnosis of the liver diseases. Jpn J Med Ultasonics, 2009. 36:301–18. (Japanese).
Sumino Y, Takayama R, Nakajima S, et al. Ultrasound of the diffuse liver diseases. Kan-Tan-Sui. 2010;60:395–407. (Japanese).
Sumino Y, Wakui N, Takayama R. Usefulness of the blood flow analysis with using the contrast enhanced ultrasound in patient with liver disease. INNERVISION. 2011;26:36–8. (Japanese).
Ichida F, Omata M, Tsuji T, et al. Histopathological diagnostic criterion of the chronic hepatitis. In: Inuyama symposium, Chugai Co., Tokyo; 1996, p. 183–8. (Japanese).
Wakui N, Takayama R, Kanekawa T, et al. Usefulness of arrival time parametric imaging in evaluating the degree of liver disease progression in chronic hepatitis C infection. J Ultrasound Med. 2012;31:373–82.
Wakui N, Takayama R, Kanekawa T, et al. Usefulness of parametric imaging in analyzing the portal blood flow. Jpn J Portal Hypertens. 2012;18:14–8. (Japanese).
Nakanuma Y, Kouda A, Katayanagi K. Pathology of the idiopathic portal hypertension. Kan-Tan-Sui. 1999;38:35–41. (Japanese).
Sato Y, Kitamura S, Kitao A, et al. Pathology and pathogenesis of idiopathic portal hypertension. Kan-Tan-Sui. 2010;61:133–40. (Japanese).
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Sumino, Y. (2019). Contrast-Enhanced Ultrasound of Liver Cirrhosis. In: Obara, K. (eds) Clinical Investigation of Portal Hypertension. Springer, Singapore. https://doi.org/10.1007/978-981-10-7425-7_10
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DOI: https://doi.org/10.1007/978-981-10-7425-7_10
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