Skip to main content

Using Continuous Glucose Monitoring for Patients with Insulinoma

  • Chapter
  • First Online:
  • 1073 Accesses

Abstract

Insulinoma is a tumor mainly made up of specialized pancreatic islet β-cells, and it is characterized by recurrent fasting hypoglycemia. Because hypoglycemic events usually occur during night or in the early morning and different individuals have different plasma glucose thresholds for hypoglycemic symptoms, early detection of insulinoma is often difficult. Continuous glucose monitoring (CGM) techniques can be used to monitor the blood glucose variation and to identify hypoglycemia, especially nocturnal hypoglycemia, which cannot be detected by self-monitoring blood glucose (SMBG). In-depth analyses of the time distribution, type, and pattern of hypoglycemia, especially in combination with fasting test, facilitate the diagnosis of insulinoma. Moreover, CGM helps to develop a comprehensive understanding of postoperative blood glucose changes as well as to accurately assess surgical efficacy in patients with insulinoma.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Calledder GG, Rich TA, Perrier ND. Multiple endocrine neoplasia syndromes. Surg Clin North Am. 2008;88:863–95. https://doi.org/10.1016/j.suc.2008.05.001.

    Article  Google Scholar 

  2. Muro S, Nasu J, Harada R, Matsubara M, Nakarai A, Kanzaki H, Tsutsumi K, Kato H, Tanaka T, Fujiwara H, Uno M, Okada H, Yamamoto K. Prompt resolution of hypoglycemia by hepatic transarterial embolization for malignant insulinoma with multiple liver metastases. Acta Med Okayama. 2014;68:303–6. https://doi.org/10.18926/AMO/52900.

    Article  PubMed  Google Scholar 

  3. Varas M, Gornals J, Ponseti JM, Alastruè A, Durán C, Llevaria C, Ballesta C, Díez-Caballero A, Artigas V. Pancreatic endocrine tumors or apudomas. Rev Esp Enferm Dig. 2011;103:184–90.

    Article  PubMed  Google Scholar 

  4. Grant CS. Insulinoma. Best Pract Res Clin Gastroenterol. 2005;19:783–98. https://doi.org/10.1016/j.bpg.2005.05.008.

    Article  PubMed  CAS  Google Scholar 

  5. Ito T, Igarashi H, Jensen RT. Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances. Best Pract Res Clin Gastroenterol. 2012;26:737–53. https://doi.org/10.1016/j.bpg.2012.12.003.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Han JF, Zhang F, Bao YQ, Zhou J, Lu W, Lu JX, Jia WP. Diagnostic value of parameters of glucose metabolism as screening tests for insulinoma. Zhonghua Yi Xue Za Zhi. 2010;90:1093–6. https://doi.org/10.3760/cma.j.issn.0376-2491.2010.16.005.

    Article  PubMed  CAS  Google Scholar 

  7. Vaidakis D, Karoubalis J, Pappa T, Piaditis G, Zografos GN. Pancreatic insulinoma: current issues and trends. Hepatobiliary Pancreat Dis Int. 2010;9:234–41.

    PubMed  Google Scholar 

  8. Patel S, Narwari M, Parekh D, Shah V. Insulinoma: case report and review of diagnostic and treatment modalities. J Assoc Physicians India. 2013;61:423–6.

    PubMed  Google Scholar 

  9. Anakal MG, Kalra P, Dharmalingam M, Indushekhar S, Rao V, Prasanna Kumar KM. Insulinoma case series: experience of a tertiary care center. Indian J Endocrinol Metab. 2014;18:858–62. https://doi.org/10.4103/2230-8210.141385.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Han JF, Zhang F, Bao YQ, Zhou J, Lu W, Lu JX, Zhao JG, Huang XY, Bao ZK, Hu B, Jia WP. A case with insulinoma localized by combined use of various means. Chin Med J. 2011;124:476–9.

    PubMed  Google Scholar 

  11. Monsod TP, Flanagan DE, Rife F, Saenz R, Caprio S, Sherwin RS, Tamborlane WV. Do sensor glucose levels accurately predict plasma glucose concentrations during hypoglycemia and hyperinsulinemia? Diabetes Care. 2002;25:889–93.

    Article  CAS  PubMed  Google Scholar 

  12. Caplin NJ, O’Leary P, Bulsara M, Davis EA, Jones TW. Subcutaneous glucose sensor values closely parallel blood glucose during insulin-induced hypoglycaemia. Diabet Med. 2003;20:238–41. https://doi.org/10.1046/j.1464-5491.2003.00837.x.

    Article  PubMed  CAS  Google Scholar 

  13. Wang X. Application of the continuous glucose monitoring system (CGMS) in the 72-hour fast test in two patients with hypoglycemia. Diabetes Technol Ther. 2004;6:883. https://doi.org/10.1089/dia.2004.6.883.

    Article  PubMed  Google Scholar 

  14. Zhou J, Jia WP, Bao YQ, Lu W, Ma XJ, Yu M, Pan JM, Hu C, Xiang KS. Characteristics and clinical significance of daily blood glucose profiles of insulinoma detected by continuous glucose monitoring system. J Shanghai Jiaotong Univ (Med Sci). 2007;27:781–4. https://doi.org/10.3969/j.issn.1674-8115.2007.07.006.

    Article  CAS  Google Scholar 

  15. Munir A, Choudhary P, Harrison B, Heller S, Newell-Price J. Continuous glucose monitoring in patients with insulinoma. Clin Endocrinol. 2008;68:912–8. https://doi.org/10.1111/j.1365-2265.2007.03161.x.

    Article  CAS  Google Scholar 

  16. Cheyne EH, Cavan DA, Kerr D. Performance of a continuous glucose monitoring system during controlled hypoglycaemia in healthy volunteers. Diabetes Technol Ther. 2002;4:607–13. https://doi.org/10.1089/152091502320798222.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Y. Bao .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Nature Singapore Pte Ltd. and Shanghai Scientific and Technical Publishers

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Han, J.F., Bao, Y. (2018). Using Continuous Glucose Monitoring for Patients with Insulinoma. In: Jia, W. (eds) Continuous Glucose Monitoring. Springer, Singapore. https://doi.org/10.1007/978-981-10-7074-7_18

Download citation

  • DOI: https://doi.org/10.1007/978-981-10-7074-7_18

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-7073-0

  • Online ISBN: 978-981-10-7074-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics