Skip to main content
  • 807 Accesses

Abstract

Conflicts of interest in biomedicine have perhaps existed in some form since the dawn of medicine with healers more apt to recommend therapies whose use would lead to some benefit for the healer, whether directly through financial gain or indirectly through gains in reputation and prestige. However, over recent decades, conflicts of interest and their potential to bias the medical literature and, consequently, medical practice have grown in frequency and degree [1]. For this reason, the management of potential conflicts of interest has become a critical component in the communication and publication of biomedical science. Editors, publishers, researchers, peer reviewers and funders are among the involved stakeholders who must be aware of conflicts of interest and cooperate in managing conflicts in an ethical and transparent manner.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Campbell EG, Gruen RL, Mountford J, Miller LG, Cleary PD, Blumenthal D. A national survey of physician–industry relationships. N Engl J Med. 2007;356:1742–50.

    Article  CAS  PubMed  Google Scholar 

  2. Author Responsibilities—Conflicts of Interest. http://www.icmje.org/recommendations/browse/roles-and-responsibilities/author-responsibilities--conflicts-of-interest.html. Accessed 28 Aug 2015.

  3. Davidoff F. Where’s the bias? Ann Intern Med. 1997;126:986–8.

    Article  CAS  PubMed  Google Scholar 

  4. Declaration of competing interests. http://www.bmj.com/about-bmj/resources-authors/forms-policies-and-checklists/declaration-competing-interests. Accessed 28 Aug 2015.

  5. ICMJE Conflict of disclosure form. http://www.icmje.org/conflicts-of-interest/. Accessed 1 May 2015.

  6. Lo B, Field MJ, editors. Institute of Medicine (US) Committee on Conflict of Interest in Medical Research, Education, and Practice. Washington, DC: National Academies Press (US); 2009.

    Google Scholar 

  7. Bekelman JE, Li Y, Gross CP. Scope and impact of financial conflicts of interest in biomedical research: a systematic review. JAMA. 2003;289:454–65.

    Article  PubMed  Google Scholar 

  8. Friedman LS, Richter ED. Relationship between conflicts of interest and research results. J Gen Intern Med. 2004;19:51–6.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Tereskerz PM, Hamric AB, Guterbock TM, Moreno JD. Prevalence of industry support and its relationship to research integrity. Account Res. 2009;16:78–105.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Kjaergard LL, Als-Nielsen B. Association between competing interests and authors’ conclusions: epidemiological study of randomized clinical trials published in BMJ. BMJ. 2002;325:249.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Djulbegovic B, Lacevic M, Cantor A, Fields KK, Bennet CL, Adams JR, et al. The uncertainty principle and industry-sponsored research. Lancet. 2000;356:635–8.

    Article  CAS  PubMed  Google Scholar 

  12. Drazen JM. Revisiting the commercial–academic interface. N Engl J Med. 2015;372:1853–4.

    Article  PubMed  Google Scholar 

  13. Zerhouni EA. Translational and clinical science—time for a new vision. N Engl J Med. 2005;353:1621–3.

    Article  CAS  PubMed  Google Scholar 

  14. Gulbrandsen M, Smeby JC. Industry funding and university professors’ research performance. Res Policy. 2005;34:932–50.

    Article  Google Scholar 

  15. Davidoff F, DeAngelis CD, Drazen JM, Hoey J, Højgaard L, Horton R, et al. Sponsorship, authorship, and accountability. Ann Intern Med. 2001;135:463–6.

    Article  CAS  PubMed  Google Scholar 

  16. Drazen JM, Van der Weyden MB, Sahni P, Rosenberg J, Marusic A, Laine C, et al. Uniform format for disclosure of competing interests in ICMJE journals. Ann Intern Med. 2010;152:125–6.

    Article  PubMed  Google Scholar 

  17. Drazen JM, de Leeuw PW, Laine C, Mulrow CD, DeAngelis CD, Frizelle FA, et al. Toward more uniform conflict disclosures: the updated ICMJE conflict of interest reporting form. Ann Intern Med. 2010;153:268–9.

    Article  PubMed  Google Scholar 

  18. The Editors. Publishing commentary by authors with potential conflicts of interest: when, why, and how. Ann Intern Med. 2004;141:73–4.

    Article  Google Scholar 

  19. Angell M, Kassirer JP. Editorials and conflicts of interest. N Engl J Med. 1996;335:1055–6.

    Article  CAS  PubMed  Google Scholar 

  20. Drazen JM, Curfman GD. Financial associations of authors. N Engl J Med. 2002;346:1901–2.

    Article  PubMed  Google Scholar 

  21. Brockway LM, Furcht LT. Conflicts of interest in biomedical research—the FASEB guidelines. FASEB J. 2006;20:2435–8.

    Article  CAS  PubMed  Google Scholar 

  22. Wager E, Kleinert S. Chapter 50: Responsible research publication: International standards for authors. A position statement developed at the 2nd World Conference on Research Integrity, Singapore, 22–24 July 2010. In: Mayer T, Steneck N, editors. Promoting research integrity in a global environment. Singapore: Imperial College Press/World Scientific Publishing; 2011. p. 309–16. ISBN: 978-981-4340-97-7.

    Google Scholar 

  23. Battisti WP, Wager E, Baltzer L, Bridges D, Cairns A, Carswell CI, et al. Good publication practice for communicating company-sponsored medical research: GPP3. Ann Intern Med. 2015;163:461–4. https://doi.org/10.7326/M15-0288.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Christine Laine .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 The National Medical Journal of India

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Laine, C. (2018). Conflicts of Interest. In: Sahni, P., Aggarwal, R. (eds) Reporting and Publishing Research in the Biomedical Sciences. Springer, Singapore. https://doi.org/10.1007/978-981-10-7062-4_22

Download citation

  • DOI: https://doi.org/10.1007/978-981-10-7062-4_22

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-7061-7

  • Online ISBN: 978-981-10-7062-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics