Abstract
Ultraviolet (UV) radiation is recognized as an essential risk factor due to its dual role of affecting the human skin. Primarily, it is required for natural vitamin D synthesis in the skin which is indispensable for human health in many constructive ways. On the other hand, UV radiation acts as a non-specific damaging agent and a mutagen as well. UV radiation has potential to cause both cancer initiation and progression. Excessive and repeated exposure to UV is associated with health risks, including pigment changes, wrinkle formation, atrophy, and malignancy. Epidemiologically and molecularly UV is linked to DNA damage, either directly or indirectly via oxidative injury resulting in various types of skin cancer. Genetic factors also stimulate threat of UV-mediated skin anomalies. This chapter emphasizes on genetic and molecular mechanisms of pigmentation, tanning, DNA damage and repair, Melanocortin 1 receptor (MC1R) gene expression, photoproduct formation, and p53 mutation.
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References
Ito S, Wakamatsu K, Ozeki H (2000) Chemical analysis of melanins and its application to the study of the regulation of melanogenesis. Pigment Cell Melanoma Res 13(s8):103–109
Jablonski NG, Chaplin G (2010) Human skin pigmentation as an adaptation to UV radiation. Proc Natl Acad Sci 107(Supplement 2):8962–8968
D’Orazio J, Jarrett S, Amaro-Ortiz A, Scott T (2013) UV radiation and the skin. Int J Mol Sci 14(6):12222–12248
Narayanan DL, Saladi RN, Fox JL (2010) Ultraviolet radiation and skin cancer. Int J Dermatol 49(9):978–986
Tatalovich Z, Wilson JP, Mack T, Yan Y, Cockburn M (2006) The objective assessment of lifetime cumulative ultraviolet exposure for determining melanoma risk. J Photochem Photobiol B Biol 85(3):198–204
Kohen E, Santus R, Hirschberg JG (1995) Photobiology. Elsevier, p 16
Norval M (2006) The mechanisms and consequences of ultraviolet-induced immunosuppression. Prog Biophys Mol Biol 92(1):108–118
Yamaguchi Y, Takahashi K, Zmudzka BZ, Kornhauser A, Miller SA, Tadokoro T, Berens W, Beer JZ, Hearing VJ (2006) Human skin responses to UV radiation: pigment in the upper epidermis protects against DNA damage in the lower epidermis and facilitates apoptosis. FASEB J 20(9):1486–1488
Skobowiat C, Dowdy JC, Sayre RM, Tuckey RC, Slominski A (2011) Cutaneous hypothalamic-pituitary-adrenal axis homolog: regulation by ultraviolet radiation. Am J Physiol-Endocrinol Metab 301(3):E484–E493
Skobowiat C, Sayre RM, Dowdy JC, Slominski AT (2013) Ultraviolet radiation regulates cortisol activity in a waveband-dependent manner in human skin ex vivo. Br J Dermatol 168(3):595–601
Norman AW (2008) From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr 88(2):491S–499S
Chaplin G, Jablonski NG (2009) Vitamin D and the evolution of human depigmentation. Am J Phys Anthropol 139(4):451–461
Khazai N, Judd SE, Tangpricha V (2008) Calcium and vitamin D: skeletal and extraskeletal health. Curr Rheumatol Rep 10(2):110–117
Kawada A (2000) Risk and preventive factors for skin phototype. J Dermatol Sci 23:S27–S29
Miller SA, Coelho SG, Zmudzka BZ, Bushar HF, Yamaguchi Y, Hearing VJ, Beer JZ (2008) Dynamics of pigmentation induction by repeated ultraviolet exposures: dose, dose interval and ultraviolet spectrum dependence. Br J Dermatol 159(4):921–930
Schlenz K, Smuda C, Batzer J, Stä F, Wenck H, Elsaesser HP, Wolber R (2005) Pigmentation mechanisms induced by different wavelength of Uv light. Pigment Cell Res 18:33
Choi W, Miyamura Y, Wolber R, Smuda C, Reinhold W, Liu H, Kolbe L, Hearing VJ (2010) Regulation of human skin pigmentation in situ by repetitive UV exposure: molecular characterization of responses to UVA and/or UVB. J Investig Dermatol 130(6):1685–1696
Schulz I, Mahler HC, Boiteux S, Epe B (2000) Oxidative DNA base damage induced by singlet oxygen and photosensitization: recognition by repair endonucleases and mutagenicity. Mutat Res/DNA Repair 461(2):145–156
Kunisada M, Sakumi K, Tominaga Y, Budiyanto A, Ueda M, Ichihashi M, Nakabeppu Y, Nishigori C (2005) 8-Oxoguanine formation induced by chronic UVB exposure makes Ogg1 knockout mice susceptible to skin carcinogenesis. Cancer Res 65(14):6006–6010
Meredith P, Sarna T (2006) The physical and chemical properties of eumelanin. Pigment Cell Melanoma Res 19(6):572–594
Song X, Mosby N, Yang J, Xu A, Abdel-Malek Z, Kadekaro AL (2009) α-MSH activates immediate defense responses to UV-induced oxidative stress in human melanocytes. Pigment Cell Melanoma Res 22(6):809–818
Kadekaro AL, Chen J, Yang J, Chen S, Jameson J, Swope VB, Cheng T, Kadakia M, Abdel-Malek Z (2012) Alpha-melanocyte–stimulating hormone suppresses oxidative stress through a p53-mediated signaling pathway in human melanocytes. Mol Cancer Res 10(6):778–786
Bickers DR, Athar M (2006) Oxidative stress in the pathogenesis of skin disease. J Investig Dermatol 126(12):2565–2575
Agar NS, Halliday GM, Barnetson RS, Ananthaswamy HN, Wheeler M, Jones AM (2004) The basal layer in human squamous tumors harbors more UVA than UVB fingerprint mutations: a role for UVA in human skin carcinogenesis. Proc Natl Acad Sci U S A 101(14):4954–4959
Nouspikel TD (2009) DNA repair in mammalian cells. Cell Mol Life Sci 66(6):994–1009
Kane AB, Kumar V (1999) Environmental and nutritional pathology. Robbins pathologic basis of disease, pp 403–457
Daya-Grosjean L (2008) Xeroderma pigmentosum and skin cancer. In Molecular mechanisms of xeroderma pigmentosum, Springer, New York, pp 19–27
Leibeling D, Laspe P, Emmert S (2006) Nucleotide excision repair and cancer. J Mol Histol 37(5–7):225–238
DiGiovanna JJ, Kraemer KH (2012) Shining a light on xeroderma pigmentosum. J Investig Dermatol 132(3):785–796
Ratner D, Peacocke M, Zhang H, Tsou HC (2001) UV-specific p53 and PTCH mutations in sporadic basal cell carcinoma of sun-exposed skin. J Am Acad Dermatol 44(2):293–297
Benjamin CL, Ananthaswamy HN (2007) p53 and the pathogenesis of skin cancer. Toxicol Appl Pharmacol 224(3):241–248
Hussein MR, Haemel AK, Wood GS (2003) p53-related pathways and the molecular pathogenesis of melanoma. Eur J Cancer Prev 12(2):93–100
Hussain SP, Harris CC (2006) p53 biological network: at the crossroads of the cellular-stress response pathway and molecular carcinogenesis. J Nippon Med Sch 73(2):54–64
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Yadav, N., Banerjee, M. (2018). Molecular and Genetic Response of Human Skin Under Ultraviolet Radiation. In: Ray, R., Haldar, C., Dwivedi, A., Agarwal, N., Singh, J. (eds) Photocarcinogenesis & Photoprotection. Springer, Singapore. https://doi.org/10.1007/978-981-10-5493-8_3
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DOI: https://doi.org/10.1007/978-981-10-5493-8_3
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