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Spatial Interactions of Electrically Evoked Potentials in Visual Cortex Induced by Multi-retinal Electrical Stimulation in Rats

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International Conference on Biomedical and Health Informatics (ICBHI 2015)

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Abstract

Retinal prostheses are designed to electrically stimulate retinal neurons to generate artificial vision in patients with degenerative diseases such as retinitis pigmentosa (RP) or age-related macular degeneration (AMD). Considering hundreds of microelectrodes may be applied in the future retinal prosthesis to provide enough spatial information for precise perception, it is crucial to investigate the spatial properties of the visual cortex in response to retinal electric stimulation via in vivo studies, especially in multi-stimulating manner by adjacent electrodes. In this study, we use retinal multi-stimulating electrodes to stimulate retinal ganglion cells (RGCs) and record electrically evoked potentials (EEPs) in contralateral visual cortex by a 32-channel Utah array. The threshold of eliciting current for EEPs was determined with 20% of the maximum response in visual cortex. The spatial map with 32 grids for single retinal stimulation was obtained firstly, which showed the different spatial distribution to different retinal stimulation. Then the combination of two stimulation from two adjacent retinal stimulating electrode was applied to examine the spatial responses of visual cortex.

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Acknowledgement

The work described in this paper was supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region, China, through Project CityU 123412 and also supported by Guangdong Innovative and Entrepreneurial Research Team Program (No. 2013S046) and Shenzhen Peacock Plan.

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Authors and Affiliations

  1. Department of Electronic Engineering, City University of Hong Kong, Hong Kong SAR, China

    Hui Xie, Yi Wang & Leanne Lai-Hang Chan

Authors
  1. Hui Xie
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  2. Yi Wang
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  3. Leanne Lai-Hang Chan
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Corresponding author

Correspondence to Leanne Lai-Hang Chan .

Editor information

Editors and Affiliations

  1. The Chinese University of Hong Kong, Hong Kong, China

    Yuan-Ting Zhang

  2. Universidade De Coimbra, Coimbra, Portugal

    Paulo Carvalho

  3. Faculty of Electrical Engineering and Computing, University of Zagreb, Zagreb, Croatia

    Ratko Magjarevic

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Xie, H., Wang, Y., Chan, L.LH. (2019). Spatial Interactions of Electrically Evoked Potentials in Visual Cortex Induced by Multi-retinal Electrical Stimulation in Rats. In: Zhang, YT., Carvalho, P., Magjarevic, R. (eds) International Conference on Biomedical and Health Informatics. ICBHI 2015. IFMBE Proceedings, vol 64. Springer, Singapore. https://doi.org/10.1007/978-981-10-4505-9_20

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  • DOI: https://doi.org/10.1007/978-981-10-4505-9_20

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-4504-2

  • Online ISBN: 978-981-10-4505-9

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